Results 11 to 20 of about 29,468 (254)
Acta Dermato-Venereologica, 2018 Abnormally high production of melanin or melanogenesis in skin melanocytes results in hyperpigmentation disorders, such as melasma, senile lentigines or freckles.
Sulekha Kumari +3 more
doaj +5 more sources
Mechanisms regulating melanogenesis* [PDF]
Anais Brasileiros de Dermatologia, 2013 Skin pigmentation is an important human phenotypic trait whose regulation, in spite of recent advances, has not yet been fully understood. The pigment melanin is produced in melanosomes by melanocytes in a complex process called melanogenesis. The melanocyte interacts with endocrine, immune, inflammatory and central nervous systems, and its activity is
Videira, Inês Ferreira dos Santos +2 more
openaire +4 more sources
Molecules, 2021 When skin is exposed to UV radiation, melanocytes produce melanin. Excessive melanin production leads to skin pigmentation, which causes various cosmetic and health problems.
Ji-Hyun Lee +6 more
doaj +1 more source
Multimodal Approach for Recalcitrant Melasma Using Picosecond Laser and Topical JAK Inhibition: A Case Report. [PDF]
J Cosmet DermatolABSTRACT Background Melasma is a chronic hyperpigmentation disorder with high relapse rates, particularly in Fitzpatrick skin types III–V. Increasing evidence implicates cytokine‐driven inflammation and visible light–induced melanogenesis as key contributors to disease persistence.
Ashkanani H +3 more
europepmc +2 more sources
A constitutively active Gαi3 protein corrects the abnormal retinal pigment epithelium phenotype of Oa1-/- mice. [PDF]
, 2013 PurposeOcular Albinism type 1 (OA1) is a disease caused by mutations in the OA1 gene and characterized by the presence of macromelanosomes in the retinal pigment epithelium (RPE) as well as abnormal crossing of the optic axons at the optic chiasm.
Ahmedli, Novruz B +4 more
core +6 more sources
Cells, 2021 Fluoroquinolones cause phototoxic reactions, manifested as different types of skin lesions, including hyperpigmentation. The disturbances of melanogenesis indicate that fluoroquinolones may affect cellular processes in melanocytes.
Justyna Kowalska +5 more
doaj +1 more source
Perspective approaches on melanogenesis inhibition
Dermatologica Sinica, 2021 Melanogenesis is a melanin-forming process responsible for protecting the skin against ultraviolet radiation damage. An excess production of melanin, however, may result in hyperpigmentation (darkening of the skin) to adverse dermatological effects ...
Aimi Syamima Abdul Manap +5 more
doaj +1 more source
Symurban Nanocrystals for Advanced Anti-Pollution Skincare [PDF]
, 2020 Several of most common dermatoses worldwide, e.g., psoriasis and atopic dermatitis, are worsened in their clinical picture when the skin is regularly exposed to an increased air pollution level, e.g., particulate matter.
Köpke, Daniel, Pyo, Sung Min
core +1 more source
Transplantable melanomas in hamsters and gerbils as models for human melanoma : sensitization in melanoma radiotherapy : from animal models to clinical trials [PDF]
, 2018 The focus of the present review is to investigate the role of melanin in the radioprotection of melanoma and attempts to sensitize tumors to radiation by inhibiting melanogenesis. Early studies showed radical scavenging, oxygen consumption and adsorption
Andrzej Słominski +11 more
core +1 more source
Mechanistic studies of anti-hyperpigmentary compounds: elucidating their inhibitory and regulatory actions. [PDF]
, 2014 Searching for depigmenting agents from natural sources has become a new direction in the cosmetic industry as natural products are generally perceived as relatively safer.
Cheng, CH +3 more
core +2 more sources