Results 11 to 20 of about 283,745 (306)

Inflammatory Cytokine Pattern Is Sex-Dependent in Mouse Cutaneous Melanoma Experimental Model [PDF]

Journal of Immunology Research, 2017
We present the evaluation of inflammatory cytokines in mouse cutaneous melanoma experimental model, as markers of disease evolution. Moreover, to test our experimental model, we have used low doses of dacarbazine (DTIC).
Mihaela Surcel, Carolina Constantin, Constantin Caruntu, Sabina Zurac, Monica Neagu   +4 more
doaj   +2 more sources

Understanding signaling cascades in melanoma [PDF]

, 2008
Understanding regulatory pathways involved in melanoma development and progression has advanced significantly in recent years. It is now appreciated that melanoma is the result of complex changes in multiple signaling pathways that affect growth control,
Akslen L. A., Berger A. J., Berking C., Bhoumik A., Bhoumik A., Chen X., Claffey K. P., Collisson E. A., Coppock D. L., Dahia P. L. M., Dhawan P., Dorsky R. I., Ehebauer M., Eisenmann K. M., Genersch E., Goding C. R., Goodall J., Gorden A., Guldberg P., Gurzov E. N., Herbst R. A., Hingorani S. R., Hughes M. J., Huguier S., Iozzo R. V., Jonsson M., Jorgensen K., Karin M., Kennedy N. J., Kumar R., Lacal P. M., Li N., Maeno K., Meyskens F. L., Miller J. R., Miyazono K., Niu G., Okuyama R., Omholt K., Park B. K., Piek E., Qin J.-Z., Rangaswami H., Rimm D. L., Rofstad E. K., Satyamoorthy K., Soldatencov V. A., Stewart F. A., Tago K.-i., Thomson J. A., Tokita T., Tsai E. Y., Tsao H., van Elsas A., Wu M., Yang J., Yang J., Yang Y. M., Zhou X. P.   +58 more
core   +1 more source

Concomitant medication of cetirizine in advanced melanoma could enhance anti-PD-1 efficacy by promoting M1 macrophages polarization

Journal of Translational Medicine, 2022
Background The clinical observation showed a potential additive effect of anti-PD-1 agents and cetirizine in patients with advanced melanoma. Methods Clinical outcomes of concomitant cetirizine/anti-PD-1 treatment of patients with stage IIIb–IV melanoma ...
Domenico Mallardo, Ester Simeone, Vito Vanella, Maria Grazia Vitale, Marco Palla, Luigi Scarpato, Miriam Paone, Teresa De Cristofaro, Valentina Borzillo, Alessio Cortellini, Francesca Sparano, Sandro Pignata, Francesco Fiore, Corrado Caracò, Piera Maiolino, Antonella Petrillo, Ernesta Cavalcanti, Secondo Lastoria, Paolo Muto, Alfredo Budillon, Sarah Warren, Paolo Antonio Ascierto   +21 more
doaj   +1 more source

An Evaluation of the Anti-Carcinogenic Response of Major Isothiocyanates in Non-Metastatic and Metastatic Melanoma Cells

Antioxidants, 2021
Malignant melanoma is one of the most deadly types of solid cancers, a property mainly attributed to its highly aggressive metastatic form. On the other hand, different classes of isothiocyanates, a class of phytochemicals, present in cruciferous ...
Melina Mitsiogianni, Sotiris Kyriakou, Ioannis Anestopoulos, Dimitrios T. Trafalis, Maria V. Deligiorgi, Rodrigo Franco, Aglaia Pappa, Mihalis I. Panayiotidis   +7 more
doaj   +1 more source

Research on melanoma image segmentation by incorporating medical prior knowledge [PDF]

PeerJ Computer Science, 2022
Background Melanoma image segmentation has important clinical value in the diagnosis and treatment of skin diseases. However, due to the difficulty of obtaining data sets, and the sample imbalance, the quality of melanoma image data sets is low, which ...
Hong Zhao, Aolong Wang, Chenpeng Zhang
doaj   +2 more sources

Image Training, Using Random Images of Melanoma, Performs as Well as the ABC(D) Criteria in Enabling Novices to Distinguish Between Melanoma and Mimics of Melanoma [PDF]

, 2014
Robust experimental evidence supporting many attempts to facilitate early melanoma diagnosis is lacking. In an experimental study using a browser interface we have examined diagnostic accuracy, sensitivity and specificity of novices in distinguishing ...
Bradley-Scott, Cerys, MacFarlane, S, McIntosh, R D, Rees, Jonathan L, Robertson, Karen   +4 more
core   +1 more source

Visible light is a better co-inducer of apoptosis for curcumin-treated human melanoma cells than UVA [PDF]

, 2013
Curcumin attracts worldwide scientific interest due to its anti-proliferative and apoptosis inducing effects on different tumor cells at concentrations ranging from 10 to 150 µM (3.7–55 µg/ml).
Bernd, August, Buss, Stephan, Dobra, Jadranka, Goerg, Kerstin, Hoffmann, Stephanie, Hofmann, Matthias, Kaufmann, Roland, Kippenberger, Stefan   +7 more
core   +5 more sources

Ladarixin, a dual CXCR1/2 inhibitor, attenuates experimental melanomas harboring different molecular defects by affecting malignant cells and tumor microenvironment. [PDF]

, 2017
CXCR1 and CXCR2 chemokine receptors and their ligands (CXCL1/2/3/7/8) play an important role in tumor progression. Tested to date CXCR1/2 antagonists and chemokine-targeted antibodies were reported to affect malignant cells in vitro and in animal models.
Alexeev, Vitali, Allegretti, Marcello, De Pizzol, Maria, Igoucheva, Olga, Jonas, Rebecca, Kemp, Daria Marley, Larijani, Mary, Lash, Elizabeth, Pidich, Alyson, Sato, Takami, Terai, Mizue   +10 more
core   +2 more sources

Caveolin-1 is a risk factor for postsurgery metastasis in preclinical melanoma models [PDF]

, 2014
Melanomas are highly lethal skin tumours that are frequently treated by surgical resection. However, the efficacy of such procedures is often limited by tumour recurrence and metastasis. Caveolin-1 (CAV1) has been attributed roles as a tumour suppressor,
Aguilar-Guzmán, L, Bennett, DC, Bieneck, S, Burzio, V, Fernandez, JG, Hossain, M, Leyton, L, Lobos-Gonzalez, L, Muñoz, N, Quest, AF, Silva, V, Sviderskaya, EV   +11 more
core   +2 more sources

Replacement and desmoplastic histopathological growth patterns in cutaneous melanoma liver metastases: frequency, characteristics, and robust prognostic value

The Journal of Pathology: Clinical Research, 2020
Among visceral metastatic sites, cutaneous melanoma (CM) metastasises initially to the liver in ~14–20% of cases. Liver metastases in CM patients are associated with both poor prognosis and poor response to immunotherapy.
Raymond Barnhill, Pieter‐Jan vanDam, Peter Vermeulen, Gabriel Champenois, André Nicolas, Robert V Rawson, James S Wilmott, John F Thompson, Georgina V Long, Nathalie Cassoux, Sergio Roman‐Roman, Klaus J Busam, Richard A Scolyer, Alexander J Lazar, Claire Lugassy   +14 more
doaj   +1 more source