Results 11 to 20 of about 167,841 (267)

An Evaluation of the Anti-Carcinogenic Response of Major Isothiocyanates in Non-Metastatic and Metastatic Melanoma Cells

Antioxidants, 2021
Malignant melanoma is one of the most deadly types of solid cancers, a property mainly attributed to its highly aggressive metastatic form. On the other hand, different classes of isothiocyanates, a class of phytochemicals, present in cruciferous ...
Melina Mitsiogianni, Sotiris Kyriakou, Ioannis Anestopoulos, Dimitrios T. Trafalis, Maria V. Deligiorgi, Rodrigo Franco, Aglaia Pappa, Mihalis I. Panayiotidis   +7 more
doaj   +1 more source

Research on melanoma image segmentation by incorporating medical prior knowledge [PDF]

PeerJ Computer Science, 2022
Background Melanoma image segmentation has important clinical value in the diagnosis and treatment of skin diseases. However, due to the difficulty of obtaining data sets, and the sample imbalance, the quality of melanoma image data sets is low, which ...
Hong Zhao, Aolong Wang, Chenpeng Zhang
doaj   +2 more sources

Concomitant medication of cetirizine in advanced melanoma could enhance anti-PD-1 efficacy by promoting M1 macrophages polarization

Journal of Translational Medicine, 2022
Background The clinical observation showed a potential additive effect of anti-PD-1 agents and cetirizine in patients with advanced melanoma. Methods Clinical outcomes of concomitant cetirizine/anti-PD-1 treatment of patients with stage IIIb–IV melanoma ...
Domenico Mallardo, Ester Simeone, Vito Vanella, Maria Grazia Vitale, Marco Palla, Luigi Scarpato, Miriam Paone, Teresa De Cristofaro, Valentina Borzillo, Alessio Cortellini, Francesca Sparano, Sandro Pignata, Francesco Fiore, Corrado Caracò, Piera Maiolino, Antonella Petrillo, Ernesta Cavalcanti, Secondo Lastoria, Paolo Muto, Alfredo Budillon, Sarah Warren, Paolo Antonio Ascierto   +21 more
doaj   +1 more source

Replacement and desmoplastic histopathological growth patterns in cutaneous melanoma liver metastases: frequency, characteristics, and robust prognostic value

The Journal of Pathology: Clinical Research, 2020
Among visceral metastatic sites, cutaneous melanoma (CM) metastasises initially to the liver in ~14–20% of cases. Liver metastases in CM patients are associated with both poor prognosis and poor response to immunotherapy.
Raymond Barnhill, Pieter‐Jan vanDam, Peter Vermeulen, Gabriel Champenois, André Nicolas, Robert V Rawson, James S Wilmott, John F Thompson, Georgina V Long, Nathalie Cassoux, Sergio Roman‐Roman, Klaus J Busam, Richard A Scolyer, Alexander J Lazar, Claire Lugassy   +14 more
doaj   +1 more source

Melanoma Single-Cell Biology in Experimental and Clinical Settings [PDF]

Journal of Clinical Medicine, 2021
Cellular heterogeneity is regarded as a major factor for treatment response and resistance in a variety of malignant tumors, including malignant melanoma. More recent developments of single-cell sequencing technology provided deeper insights into this phenomenon.
Hans Binder, Maria Schmidt, Henry Loeffler-Wirth, Lena Suenke Mortensen, Manfred Kunz   +4 more
openaire   +3 more sources

Hypoxic Gene Signature of Primary and Metastatic Melanoma Cell Lines: Focusing on HIF-1β and NDRG-1

Balkan Medical Journal, 2020
Background:Hypoxia is an important microenvironmental factor significantly affecting tumor proliferation and progression. The importance of hypoxia is, however, not well known in oncogenesis of malignant melanoma.Aims:To evaluate the difference of ...
Mustafa Emre Ercin, Önder Bozdoğan, Tarık Çavuşoğlu, Nazan Bozdoğan, Pınar Atasoy, Mukadder Koçak   +5 more
doaj   +1 more source

Experimental Models for Rare Melanoma Research—The Niche That Needs to Be Addressed

Bioengineering, 2023
Melanoma, the tumor arising from the malignant transformation of pigment-producing cells—the melanocytes—represents one of the most severe cancer types.
Ioana Ionita, Daniel Malita, Cristina Dehelean, Emilian Olteanu, Iasmina Marcovici, Andreea Geamantan, Sorin Chiriac, Andrea Roman, Daniela Radu   +8 more
doaj   +1 more source

Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers

Nature Communications, 2016
Cytoplasmic polyadenylated transcripts have been poorly characterized, particularly in cancer. Here the authors identify a lineage-specific requirement of the cytoplasmic polyadenylation binding protein 4 (CPEB4) in malignant melanoma and show that it ...
Eva Pérez-Guijarro, Panagiotis Karras, Metehan Cifdaloz, Raúl Martínez-Herranz, Estela Cañón, Osvaldo Graña, Celia Horcajada-Reales, Direna Alonso-Curbelo, Tonantzin G. Calvo, Gonzalo Gómez-López, Nicolas Bellora, Erica Riveiro-Falkenbach, Pablo L. Ortiz-Romero, José L. Rodríguez-Peralto, Lorena Maestre, Giovanna Roncador, Juan C. de Agustín Asensio, Colin R. Goding, Eduardo Eyras, Diego Megías, Raúl Méndez, María S. Soengas   +21 more
doaj   +1 more source

Macrophage Effector Mechanisms in Melanoma in an Experimental Study [PDF]

Archives of Surgery, 2001
The tumor-bearing state is known to induce immune dysfunction that contributes to increased infectious complications and tumor progression. However, the mechanisms underlying this immunosuppression remain unclear.Macrophage (MO) dysfunction may play a role in tumor-induced immunosuppression.Using a murine model, this study investigated the effects of ...
H A, Naama, V E, Mack, G P, Smyth, P P, Stapleton, J M, Daly   +4 more
openaire   +2 more sources

A new 12-gene diagnostic biomarker signature of melanoma revealed by integrated microarray analysis [PDF]

PeerJ, 2013
Genome-wide microarray technology has facilitated the systematic discovery of diagnostic biomarkers of cancers and other pathologies. However, meta-analyses of published arrays often uncover significant inconsistencies that hinder advances in clinical ...
Wanting Liu, Yonghong Peng, Desmond J. Tobin   +2 more
doaj   +2 more sources