Results 31 to 40 of about 283,745 (306)

Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets

Nature Communications, 2019
Mucosal melanomas are challenging to treat partly because so little is known about the genetic drivers underpinning them. Here, the authors perform a genomic landscape analysis of samples collected from three continents, revealing a potential role for ...
Felicity Newell, Yan Kong, James S. Wilmott, Peter A. Johansson, Peter M. Ferguson, Chuanliang Cui, Zhongwu Li, Stephen H. Kazakoff, Hazel Burke, Tristan J. Dodds, Ann-Marie Patch, Katia Nones, Varsha Tembe, Ping Shang, Louise van der Weyden, Kim Wong, Oliver Holmes, Serigne Lo, Conrad Leonard, Scott Wood, Qinying Xu, Robert V. Rawson, Pamela Mukhopadhyay, Reinhard Dummer, Mitchell P. Levesque, Göran Jönsson, Xuan Wang, Iwei Yeh, Hong Wu, Nancy Joseph, Boris C. Bastian, Georgina V. Long, Andrew J. Spillane, Kerwin F. Shannon, John F. Thompson, Robyn P. M. Saw, David J. Adams, Lu Si, John V. Pearson, Nicholas K. Hayward, Nicola Waddell, Graham J. Mann, Jun Guo, Richard A. Scolyer   +43 more
doaj   +1 more source

New Insights into the Runt Domain of RUNX2 in Melanoma Cell Proliferation and Migration [PDF]

, 2018
The mortality rate for malignant melanoma (MM) is very high, since it is highly invasive and resistant to chemotherapeutic treatments. The modulation of some transcription factors affects cellular processes in MM.
Antoniazzi, Franco, Brandi, Jessica, Cecconi, Daniela, Cheri, Samuele, Dalle Carbonare, Luca, Deiana, Michela, Gandini, Alberto, Innamorati, Giulio, Malerba, Giovanni, Manfredi, Marcello, Marchetto, Giulia, Marengo, Emilio, Mina, Maria Mihaela, Mori, Antonio, Mottes, Monica, Parolini, Francesca, Serena, Michela, Tiso, Natascia, Valenti, Maria Teresa, Zipeto, Donato   +19 more
core   +2 more sources

Haematoporphyrin photosensitisation treatment of experimental choroidal melanoma [PDF]

Eye, 1987
Greene amelanotic melanoma transplanted to pigmented rabbit choroid provided the experimental model for studying photosensitisation treatment of choroidal melanoma. Administration of haematoporphyrin derivative (HPD) and subsequent photoradiation with green laser light destroyed much of the melanoma with minimal side effects to normal uvea. The results
A M, Phillips, B H, Browne, D, Allan, P J, Szczesny, W R, Lee, W S, Foulds   +5 more
openaire   +2 more sources

Regulatory T cells in melanoma revisited by a computational clustering of FOXP3+ T cell subpopulations [PDF]

, 2015
CD4+ T cells that express the transcription factor FOXP3 (FOXP3+ T cells) are commonly regarded as immunosuppressive regulatory T cells (Treg). FOXP3+ T cells are reported to be increased in tumour-bearing patients or animals, and considered to suppress ...
Fujii, H, Husson, F, Josse, J, Miyachi, Y, Ono, M, Tanioka, M   +5 more
core   +3 more sources

Combining single-cell and transcriptomic analysis revealed the immunomodulatory effect of GOT2 on a glutamine-dependent manner in cutaneous melanoma

Frontiers in Pharmacology, 2023
Background: Reprogramming in glutamine metabolism is a hallmark of cancers, while its role in cutaneous melanoma has not been studied at great length.Methods: Here, we constructed a glutamine metabolism-related prognostic signature in cutaneous melanoma ...
Lebin Song, Xiyi Wei, Xi Zhang, Yan Lu
doaj   +1 more source

Lipid storage and autophagy in melanoma cancer cells [PDF]

, 2017
Cancer stem cells (CSC) represent a key cellular subpopulation controlling biological features such as cancer progression in all cancer types. By using melanospheres established from human melanoma patients, we compared less differentiated melanosphere ...
Cordella, Martina, Eramo, A, Facchiano, A, Facchiano, F, Filippini, Antonio, Giampietri, Claudia, Petrungaro, Simonetta, Tabolacci, C, Tomaipitinca, Luana, Ziparo, Elio   +9 more
core   +2 more sources

Exosome-mediated transfer of miR-222 is sufficient to increase tumor malignancy in melanoma [PDF]

, 2016
BACKGROUND: Growing evidence is showing that metastatic cell populations are able to transfer their characteristics to less malignant cells. Exosomes (EXOs) are membrane vesicles of endocytic origin able to convey their cargo of mRNAs, microRNAs (miRs),
Bellenghi, Maria, Carè, Alessandra, Coscia, Carolina, Errico, Maria Cristina, Felicetti, Federica, Feo, Alessandra De, Pagani, Elena, Pasquini, Luca, Pedini, Francesca, Puglisi, Rossella   +9 more
core   +5 more sources

Loss of testosterone impairs anti-tumor neutrophil function. [PDF]

, 2020
In men, the incidence of melanoma rises rapidly after age 50, and nearly two thirds of melanoma deaths are male. The immune system is known to play a key role in controlling the growth and spread of malignancies, but whether age- and sex-dependent ...
Arditi, Moshe, Crother, Timothy R, Lane, Malcolm E, Luu, Michael, Markman, Janet L, Martinon, Daisy, Noval Rivas, Magali, Porritt, Rebecca A, Posadas, Edwin M, Wakita, Daiko   +9 more
core   +1 more source

P-cadherin counteracts myosin II-B function : implications in melanoma progression [PDF]

, 2010
BACKGROUND: Malignant transformation of melanocytes is frequently attended by a switch in cadherin expression profile as shown for E- and N-cadherin. For P-cadherin, downregulation in metastasizing melanoma has been demonstrated, and over-expression of P-
Jacobs, Koen, Van Gele, Mireille, Forsyth, Ramses, Brochez, Lieve, Vanhoecke, Barbara, De Wever, Olivier, bracke, marc   +6 more
core   +3 more sources

Organ‐Specific Metastases in Melanoma: Experimental Animal Models [PDF]

Pigment Cell Research, 1993
Metastases from certain primary tumors frequently exhibit specific organ preference. Animal models have been developed to induce in a reproducible fashion the formation of organ‐specific metastases by malignant melanoma cells. Some of these models rely on the use of immunodeficient mice, which can support the growth of murine as well as human malignant
S. GATTONI CELLI, R. H. BYERS, CALORINI, LIDO, S. FERRONE   +3 more
openaire   +3 more sources