Results 31 to 40 of about 167,841 (267)
Effect of hyperthermia on experimental choroidal melanoma. [PDF]
British Journal of Ophthalmology, 1985 Thirty-five rabbit eyes were implanted subchoroidally with Greene's hamster melanoma. When the tumours reached a base diameter of 5 mm, they were treated with ultrasonically induced hyperthermia with a range of temperatures and exposure durations (43-67 degrees C and 75 s to 60 min).
S E, Burgess +5 more
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Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Nature Communications, 2017 Hundreds of mRNA binding proteins (mRBPs) have been described in mammalian cells. Here, the authors identify RBPs differentially regulated in melanoma, and show the RBP CELF1 controlling a distinct set of protumorigenic factors.
Metehan Cifdaloz +20 more
doaj +1 more source
FRIZZLED7 Is Required for Tumor Initiation and Metastatic Growth of Melanoma Cells. [PDF]
PLoS ONE, 2016 Metastases are thought to arise from cancer stem cells and their tumor initiating abilities are required for the establishment of metastases. Nevertheless, in metastatic melanoma, the nature of cancer stem cells is under debate and their contribution to ...
Shweta Tiwary, Lei Xu
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Immunohistochemical Characterization of Experimental Greene Melanoma
Ophthalmic Research, 2009 20 experimental amelanotic Greene melanomas implanted into the anterior chamber of rabbit eyes were examined immunohistochemically in paraffin sections. All the Greene melanomas were found to be positive for vimentin, S-100 and HMB 45 and negative for α-human chorionic gonadotropin, neuron-specific enolase, chromogranin, synaptophysin, cytokeratin ...
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Systemic Chemotherapy Is Modulated by Platelet-Activating Factor-Receptor Agonists
Mediators of Inflammation, 2015 Chemotherapy is used to treat numerous cancers including melanoma. However, its effectiveness in clinical settings is often hampered by various mechanisms.
Ravi P. Sahu +2 more
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Machine learning approach in melanoma cancer stage detection
Journal of King Saud University: Computer and Information Sciences, 2022 Melanoma is a dangerous skin cancer and spreads very fast. Hence, it is the deadliest skin cancer and causes most deaths. Classification of cancer stages is a very tedious task and very important when a patient is diagnosed.
Rashmi Patil, Sreepathi Bellary
doaj +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source