Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules [PDF]
, 2018 Background: Microenvironment cues involved in melanoma progression are largely unknown. Melanoma is highly influenced in its aggressive phenotype by the changes it determinates in its microenvironment, such as pH decrease, in turn influencing cancer cell
A Albini +67 more
core +10 more sources
Bonded Cumomer Analysis of Human Melanoma Metabolism Monitored by 13C NMR Spectroscopy of Perfused Tumor Cells. [PDF]
, 2015 A network model for the determination of tumor metabolic fluxes from (13)C NMR kinetic isotopomer data has been developed and validated with perfused human DB-1 melanoma cells carrying the BRAF V600E mutation, which promotes oxidative metabolism.
Blair, Ian A +9 more
core +2 more sources
Melanoma Single-Cell Biology in Experimental and Clinical Settings [PDF]
Journal of Clinical Medicine, 2021 Cellular heterogeneity is regarded as a major factor for treatment response and resistance in a variety of malignant tumors, including malignant melanoma. More recent developments of single-cell sequencing technology provided deeper insights into this phenomenon.
Hans Binder +4 more
openaire +3 more sources
Hypoxic Gene Signature of Primary and Metastatic Melanoma Cell Lines: Focusing on HIF-1β and NDRG-1
Balkan Medical Journal, 2020 Background:Hypoxia is an important microenvironmental factor significantly affecting tumor proliferation and progression. The importance of hypoxia is, however, not well known in oncogenesis of malignant melanoma.Aims:To evaluate the difference of ...
Mustafa Emre Ercin +5 more
doaj +1 more source
Experimental Models for Rare Melanoma Research—The Niche That Needs to Be Addressed
Bioengineering, 2023 Melanoma, the tumor arising from the malignant transformation of pigment-producing cells—the melanocytes—represents one of the most severe cancer types.
Ioana Ionita +8 more
doaj +1 more source
Nature Communications, 2016 Cytoplasmic polyadenylated transcripts have been poorly characterized, particularly in cancer. Here the authors identify a lineage-specific requirement of the cytoplasmic polyadenylation binding protein 4 (CPEB4) in malignant melanoma and show that it ...
Eva Pérez-Guijarro +21 more
doaj +1 more source
Immunological backbone of uveal melanoma: is there a rationale for immunotherapy? [PDF]
, 2019 No standard treatment has been established for metastatic uveal melanoma (mUM). Immunotherapy is commonly used for this disease even though UM has not been included in phase III clinical trials with checkpoint inhibitors.
Alessandra Cassano +24 more
core +1 more source
Macrophage Effector Mechanisms in Melanoma in an Experimental Study [PDF]
Archives of Surgery, 2001 The tumor-bearing state is known to induce immune dysfunction that contributes to increased infectious complications and tumor progression. However, the mechanisms underlying this immunosuppression remain unclear.Macrophage (MO) dysfunction may play a role in tumor-induced immunosuppression.Using a murine model, this study investigated the effects of ...
H A, Naama +4 more
openaire +2 more sources
A new 12-gene diagnostic biomarker signature of melanoma revealed by integrated microarray analysis [PDF]
PeerJ, 2013 Genome-wide microarray technology has facilitated the systematic discovery of diagnostic biomarkers of cancers and other pathologies. However, meta-analyses of published arrays often uncover significant inconsistencies that hinder advances in clinical ...
Wanting Liu +2 more
doaj +2 more sources
Evaluation of melanin-targeted radiotherapy in combination with radiosensitizing drugs for the treatment of melanoma [PDF]
, 2014 The incidence of malignant melanoma is rising faster than that of any other cancer in the United States. An [131I]-labeled benzamide - [131I]MIP-1145 - selectively targets melanin, reduces melanoma tumor burden and increases survival in preclinical ...
Babich, John +5 more
core +1 more source