Results 61 to 70 of about 34,274 (165)

Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress [PDF]

, 2009
OBJECTIVES: Memantine is an N-methyl-d-aspartate (NMDA) glutamate receptor antagonist used to treat Alzheimer's disease. Previous studies have suggested that receptor blockers act as neuroprotective agents; however, no study has specifically investigated
MENEGHINI, Adriano, FERREIRA, Celso, ABREU, Luiz Carlos de, VALENTI, Vitor E., FERREIRA, Marcelo, F. FILHO, Celso, MURAD, Neif   +6 more
core   +3 more sources

The Role of Magnetic Resonance Spectroscopy (MRS), Diffusion‐Tensor‐Imaging (DTI) and Structural MRI in the Alzheimer's Disease and Mild Cognitive Impairment Diagnosis: A Review

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Alzheimer's disease (AD) is one of the most common neurological disorders affecting older adults, with approximately 7.2 million cases only in the United States. This number is projected to increase to 13.8 million in the United States by 2060, leading to increased expenditures for healthcare, long‐term care and hospice services. Consequently,
Valentina Zecca, Gianmauro Palombelli, Nicola Vanacore, Rossella Canese   +3 more
wiley   +1 more source

Bioequivalence study drug containing memantine

Фармакокинетика и Фармакодинамика, 2013
At present, Russia has developed domestic analogue of Memantine Akatinol — Memaneyrin in the form of droplets which is pharmaceutically equivalent drug memantine Akatinol.
A. A. Karlitskaya, L. M. Krasnyh, V. V. Smirnov, G. F. Vasilenko, N. I. Kuznetsova, V. G. Kukes   +5 more
doaj  

Interactions of memantine and rivastigmine with graphene oxide nanocarrier and beta-amyloid protein using molecular docking and in-silico methods

Heliyon
Alzheimer's disease is characterized by the accumulation of beta-amyloid plaques and neurofibrillary tangles. Effective therapeutic strategies involve inhibiting the formation of beta-amyloid aggregates and destabilizing existing ones.
Fateme Davoudi, Nasrin Shadjou, Mahdieh Darroudi   +2 more
doaj   +1 more source

Maniform episode related to memantine therapy: unraveling of an unknown adverse side effect?

Psicosomática y Psiquiatría, 2021
Introduction: Memantine, a type of N-methyl-D-aspartate (NMDA) antagonist, is a drug approved by Food and Drug Administration to the treatment of moderate-to-severe Alzheimer disease (AD).
Catarina da Costa Campos, Joana Mesquita
doaj   +1 more source

Monoaminergic Networks of Cognitive and Behavioral Symptoms in Early Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is associated with several behavioral and cognitive symptoms, the neurobiological background of which is not yet fully understood. Objectives The aim was to investigate the association between monoamine function and four specific nonmotor symptoms in early PD using the Parkinson's Progression Markers ...
Kalle J. Niemi, Valtteri Kaasinen, Rimona S. Weil, Juho Joutsa   +3 more
wiley   +1 more source

Xanthatin‐13‐(Pyrrolidine‐2‐Carboxylic Acid), a Sesquiterpene Lactone Isolated From Burdock Leaf, Attenuated Aβ25‐35 Toxicity and Memory Deficits in a Pharmacological Mouse Model of Alzheimer's Disease

Phytotherapy Research, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a severe form of dementia, which occurrence increases with age and lifestyle conditions. It is characterized by amyloid protein accumulation forming senile plaques, hyperphosphorylated tau protein forming neurofibrillary tangles, neuroinflammation, and oxidative stress, leading to synapse loss and cell death ...
Charlyne Barry‐Simonnet, Lucie Crouzier, Tristan Moujellil‐Legagneur, Hamza Chaieb‐Errass, Yanis A. Idres, Karine Ferrare, Marc Rolland, Guillaume Cazals, Patrick Poucheret, Tangui Maurice, Didier Tousch   +10 more
wiley   +1 more source

Effect of Memantine on Overactive Detrusor in Rats With Spinal Cord Injury

Kaohsiung Journal of Medical Sciences, 2010
The aim of this study was to determine the effect of memantine on overactive detrusor (OAD) 15 days after spinal cord injury (SCI) in rats. Twenty-eight adult Wistar rats were used in this study.
Cüneyd Özkürkçügil, Osman Kömür, Levend Özkan   +2 more
doaj   +1 more source

Memantine increases NMDA receptor level in the prefrontal cortex but fails to reverse apomorphine-induced conditioned place preference in rats [PDF]

, 2018
Studies have shown that inflammation and neurodegeneration may accompany the development of addiction to apomorphine and that the glutamate NMDA receptor antagonist, memantine, may be neuroprotective.
Baxter BL, Gluckman MI, Stein L, et al., Bisaga A, Comer SD, Ward AS, et al., Campbell JC, Jeyamohan SB, De LCP, et al., Chen G, Greengard P, Yan Z, Chen SL, Tao PL, Chu CH, et al., Di CP, Everitt BJ, Dos SER, Daval J, Koziel V, et al., El-Bachá RS, Netter P, Minn A, Haleem DJ, Ikram H, Haleem MA, Kelley AE, Kemp JA, Mckernan RM, Overton PG, Clark D, Papp M, Parsons CG, Popik P, Layer RT, Skolnick P, Popik P, Skolnick P, Popik P, Wrobel M, Bisaga A, Sam E, Verbeke N, Sattler R, Tymianski M, Singh N, Pillay V, Choonara YE, Spyraki C, Fibiger HC, Phillips AG, Téllez C, Bustamante ML, Toro P, et al., Uys JD, Lalumiere RT, Van dKD, Swerdlow NR, Koob GF, Volkow ND, Fowler JS, Wang GJ, et al., Wu PH, Mihic SJ, Liu JF, et al., Zweifel LS, Argilli E, Bonci A, et al.   +26 more
core   +2 more sources

Pharmacological and Mechanistic Interventions for Cognitive Impairment Associated With Schizophrenia: A Review of Registered Clinical Trials

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian, Lena Palaniyappan, Theodore T. Kolivakis, Howard C. Margolese   +3 more
wiley   +1 more source