Soluble Membrane Attack Complex: Biochemistry and Immunobiology [PDF]
Frontiers in Immunology, 2020 The soluble membrane attack complex (sMAC, a.k.a., sC5b-9 or TCC) is generated on activation of complement and contains the complement proteins C5b, C6, C7, C8, C9 together with the regulatory proteins clusterin and/or vitronectin.
Scott R. Barnum +2 more
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Structural basis for membrane attack complex inhibition by CD59 [PDF]
Nature Communications, 2023 CD59 protects human cells from damage by the MAC immune pore. The authors show how CD59 inhibits MAC, by deflecting pore-forming β-hairpins of complement proteins.
Emma C. Couves +6 more
doaj +3 more sources
Structural basis of soluble membrane attack complex packaging for clearance [PDF]
Nature Communications, 2021 To prevent unregulated complement activation, extracellular chaperones capture soluble precursors to the membrane attack complex (sMAC). Here, structural analysis of sMAC reveals how clusterin recognizes heterogeneous sMAC complexes and inhibits ...
Anaïs Menny +5 more
doaj +3 more sources
Deposition of the Membrane Attack Complex in Healthy and Diseased Human Kidneys [PDF]
Frontiers in Immunology, 2021 The membrane attack complex—also known as C5b-9—is the end-product of the classical, lectin, and alternative complement pathways. It is thought to play an important role in the pathogenesis of various kidney diseases by causing cellular injury and tissue
Jacob J. E. Koopman +5 more
doaj +3 more sources
Membrane Attack Complex Mediates Retinal Pigment Epithelium Cell Death in Stargardt Macular Degeneration [PDF]
Cells, 2022 Recessive Stargardt disease (STGD1) is an inherited retinopathy caused by mutations in the ABCA4 gene. The ABCA4 protein is a phospholipid-retinoid flippase in the outer segments of photoreceptors and the internal membranes of retinal pigment epithelial (
Eunice Sze Yin Ng +8 more
doaj +3 more sources
Complement Membrane Attack Complex: New Roles, Mechanisms of Action, and Therapeutic Targets. [PDF]
Am J Pathol, 2020 The complement membrane attack complex (MAC) is classically known as a cytolytic effector of innate and adaptive immunity that forms pores in the plasma membrane of pathogens or targeted cells leading to osmolysis.
Xie CB, Jane-Wit D, Pober JS.
europepmc +4 more sources
Outer membrane permeabilization by the membrane attack complex sensitizes Gram-negative bacteria to antimicrobial proteins in serum and phagocytes. [PDF]
PLoS Pathogens, 2021 Infections with Gram-negative bacteria form an increasing risk for human health due to antibiotic resistance. Our immune system contains various antimicrobial proteins that can degrade the bacterial cell envelope.
Dani A C Heesterbeek +7 more
doaj +3 more sources
Single-molecule kinetics of pore assembly by the membrane attack complex [PDF]
Nature Communications, 2019 The membrane attack complex (MAC) is a hetero-oligomeric protein assembly that kills pathogens by perforating their cell envelopes. Here, the authors use atomic force microscopy to show that MAC proteins oligomerize within the membrane, allowing them to ...
Edward S. Parsons +11 more
doaj +3 more sources
Structural basis of complement membrane attack complex formation
Nature Communications, 2016 The membrane attack complex (MAC) is an immune effector that kills pathogens by forming pores in their membrane. Here the authors use cryo-electron microscopy to reveal that the full MAC is an asymmetric pore with a split-washer configuration and ...
Marina Serna +3 more
doaj +6 more sources
CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers [PDF]
Nature Communications, 2018 The complement membrane attack complex (MAC) is a lytic immune pore that kills pathogens. Here the authors use cryoEM to provide a structural and biophysical mechanism for how β-pore forming proteins breach the lipid bilayer, providing pathways to ...
Anaïs Menny +8 more
doaj +3 more sources