Results 11 to 20 of about 419,747 (259)

Polymerization of C9 enhances bacterial cell envelope damage and killing by membrane attack complex pores [PDF]

PLoS Pathogens, 2021
Complement proteins can form membrane attack complex (MAC) pores that directly kill Gram-negative bacteria. MAC pores assemble by stepwise binding of C5b, C6, C7, C8 and finally C9, which can polymerize into a transmembrane ring of up to 18 C9 monomers ...
Dennis J. Doorduijn, Dani A. C. Heesterbeek, Maartje Ruyken, Carla J. C. de Haas, Daphne A. C. Stapels, Piet C. Aerts, Suzan H. M. Rooijakkers, Bart W. Bardoel   +7 more
doaj   +3 more sources

The Membrane Attack Complex/Perforin Superfamily. [PDF]

J Mol Microbiol Biotechnol, 2017
The membrane attack complex/perforin (MACPF) superfamily consists of a diverse group of proteins involved in bacterial pathogenesis and sporulation as well as eukaryotic immunity, embryonic development, neural migration and fruiting body formation.
Moreno-Hagelsieb G, Vitug B, Medrano-Soto A, Saier MH.   +3 more
europepmc   +7 more sources

Bacterial killing by complement requires direct anchoring of membrane attack complex precursor C5b-7. [PDF]

PLoS Pathogens, 2020
An important effector function of the human complement system is to directly kill Gram-negative bacteria via Membrane Attack Complex (MAC) pores. MAC pores are assembled when surface-bound convertase enzymes convert C5 into C5b, which together with C6 ...
Dennis J Doorduijn, Bart W Bardoel, Dani A C Heesterbeek, Maartje Ruyken, Georgina Benn, Edward S Parsons, Bart W Hoogenboom, Suzan H M Rooijakkers   +7 more
doaj   +3 more sources

Complement and platelets: prothrombotic cell activation requires membrane attack complex-induced release of danger signals. [PDF]

Blood Adv, 2023
Key Points • Proximal and terminal complement activation products fail to directly induce prothrombotic platelet activation.• MAC-mediated release of intracellular ADP is sufficient and necessary for complement-mediated platelet activation.
Mannes M, Pechtl V, Hafner S, Dopler A, Eriksson O, Manivel VA, Wohlgemuth L, Messerer DAC, Schrezenmeier H, Ekdahl KN, Nilsson B, Jacobsen EM, Hoenig M, Huber-Lang M, Braun CK, Schmidt CQ.   +15 more
europepmc   +2 more sources

Temporal lobe epilepsy with GAD antibodies: neurons killed by T cells not by complement membrane attack complex. [PDF]

Brain, 2023
Temporal lobe epilepsy (TLE) is one of the syndromes linked to antibodies against glutamic acid decarboxylase (GAD). It has been questioned whether ‘limbic encephalitis with GAD antibodies’ is a meaningful diagnostic entity. The immunopathogenesis of GAD-
Tröscher AR, Mair KM, Verdú de Juan L, Köck U, Steinmaurer A, Baier H, Becker A, Blümcke I, Finzel M, Geis C, Höftberger R, Mawrin C, von Oertzen TJ, Pitsch J, Surges R, Voges B, Weis S, Winklehner M, Woermann F, Bauer J, Bien CG.   +20 more
europepmc   +2 more sources

In vitro Measurement of Membrane Attack Complex in RPE Cells [PDF]

Bio-Protocol, 2021
Initiation of the complement system results in the formation of a multiprotein pore termed the membrane attack complex (MAC, C5b-C9). MAC pores accumulate on a cell surface and can result in cell lysis.
Kelly Mulfaul, Sarah Doyle
doaj   +2 more sources

Evolution and Expression of the Membrane Attack Complex and Perforin Gene Family in the Poaceae. [PDF]

Int J Mol Sci, 2020
Membrane Attack Complex and Perforin (MACPF) proteins play crucial roles in plant development and plant responses to environmental stresses. To date, only four MACPF genes have been identified in Arabidopsis thaliana, and the functions of the MACPF gene ...
Yu L, Liu D, Chen S, Dai Y, Guo W, Zhang X, Wang L, Ma S, Xiao M, Qi H, Xiao S, Chen Q.   +11 more
europepmc   +2 more sources

The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9 [PDF]

Communications Biology, 2023
The cryo-EM structure of monoclonal antibody aE11 bound to polyC9 reveals that the binding site within the Membrane Attack Complex is a quaternary discontinuous epitope formed by two separate surfaces of the oligomeric C9 periphery.
Charles Bayly-Jones, Bill H. T. Ho, Corinna Lau, Eleanor W. W. Leung, Laura D’Andrea, Christopher J. Lupton, Susan M. Ekkel, Hariprasad Venugopal, James C. Whisstock, Tom E. Mollnes, Bradley A. Spicer, Michelle A. Dunstone   +11 more
doaj   +2 more sources

Quantitative Analysis of Complement Membrane Attack Complex Proteins Associated with Extracellular Vesicles [PDF]

Proteomes
Extracellular vesicles (EVs) represent a universal mechanism of intercellular communication in normal and pathological conditions. There are reports showing the presence of complement proteins in EV preparations, specifically those that can form a ...
Illarion V. Turko
doaj   +2 more sources

Membrane Attack Complex C5b-9 Promotes Renal Tubular Epithelial Cell Pyroptosis in Trichloroethylene-Sensitized Mice [PDF]

Frontiers in Pharmacology, 2022
Trichloroethylene (TCE), a commonly used organic solvent, is known to cause trichloroethylene hypersensitivity syndrome (THS), also called occupational medicamentosa–like dermatitis due to TCE (OMDT) in China.
Feng Wang, Meng Huang, Yican Wang, Yiting Hong, Dandan Zang, Chunjun Yang, Changhao Wu, Qixing Zhu, Qixing Zhu   +8 more
doaj   +2 more sources