Results 21 to 30 of about 419,747 (259)

Structural basis for membrane attack complex inhibition by CD59

Nature Communications, 2022
AbstractCD59 is an abundant immuno-regulatory receptor that protects human cells from damage during complement activation. Here we show how the receptor binds complement proteins C8 and C9 at the membrane to prevent insertion and polymerization of membrane attack complex (MAC) pores.
Couves EC, Gardner S, Voisin TB, Bickel JK, Stansfeld PJ, Tate EW, Bubeck D.   +6 more
europepmc   +9 more sources

Bacterial killing by complement requires membrane attack complex formation via surface-bound C5 convertases. [PDF]

EMBO J, 2019
The immune system kills bacteria by the formation of lytic membrane attack complexes (MACs), triggered when complement enzymes cleave C5. At present, it is not understood how the MAC perturbs the composite cell envelope of Gram‐negative bacteria.
Heesterbeek DA, Bardoel BW, Parsons ES, Bennett I, Ruyken M, Doorduijn DJ, Gorham RD, Berends ET, Pyne AL, Hoogenboom BW, Rooijakkers SH.   +10 more
europepmc   +2 more sources

Structure of the poly-C9 component of the complement membrane attack complex

Nature Communications, 2016
The membrane attack complex is a heteromeric assembly of complement proteins where multiple copies of C9 are recruited by the C5b678 complex to form lytic pores in pathogen membranes.
Natalya V. Dudkina, Bradley A. Spicer, Cyril F. Reboul, Paul J. Conroy, Natalya Lukoyanova, Hans Elmlund, Ruby H. P. Law, Susan M. Ekkel, Stephanie C. Kondos, Robert J. A. Goode, Georg Ramm, James C. Whisstock, Helen R. Saibil, Michelle A. Dunstone   +13 more
doaj   +2 more sources

Internalization of the Membrane Attack Complex Triggers NLRP3 Inflammasome Activation and IL-1β Secretion in Human Macrophages [PDF]

Frontiers in Immunology, 2021
Interleukin 1β (IL-1β) plays a major role in inflammation and is secreted by immune cells, such as macrophages, upon recognition of danger signals. Its secretion is regulated by the inflammasome, the assembly of which results in caspase 1 activation ...
Ines Diaz-del-Olmo, Jonathan Worboys, Fatima Martin-Sanchez, Anna Gritsenko, Ashley R. Ambrose, Gillian M. Tannahill, Eva-Maria Nichols, Gloria Lopez-Castejon, Daniel M. Davis   +8 more
doaj   +2 more sources

Bactericidal membrane attack complex formation initiates at the new pole of E. coli [PDF]

EMBO Reports
Human immune protection against bacteria critically depends on activation of the complement system. The direct bacteriolytic activity of complement molecules against Gram-negative bacteria acts via the formation of Membrane Attack Complex (MAC) pores ...
Marije F L van ‘t Wout, Fabian Hauser, Philippa I P Holzapfel, Bart W Bardoel, Carla J C de Haas, Jaroslaw Jacak, Suzan H M Rooijakkers, Dani A C Heesterbeek   +7 more
doaj   +2 more sources

Membrane Attack Complex and Factor H in Humans with Acute Kidney Injury

Kidney & Blood Pressure Research, 2018
Background and Aims: Complement system seems to play an important role in the pathogenesis of Acute Kidney Injury (AKI). The aim of this study was to investigate the role of complement system in the pathogenesis of human AKI. For this purpose, we studied
Eva Rodríguez, Javier Gimeno, Carlos Arias-Cabrales, Clara Barrios, Dolores Redondo- Pachón, María José Soler, Marta Crespo, Adriana Sierra-Ochoa, Marta Riera, Julio Pascual   +9 more
doaj   +2 more sources

Activation of Membrane Attack Complex [PDF]

Definitions, 2020
A series of reactions that result in formation of a pore, composed of complement proteins C5b, C6, C7, C8, and C9, in the membrane of a pathogenic cell. The pore allows free diffusion of molecules into and out of the cell and reduces cell viability.
openaire   +2 more sources

The mystery behind membrane insertion: a review of the complement membrane attack complex. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2017
The membrane attack complex (MAC) is an important innate immune effector of the complement terminal pathway that forms cytotoxic pores on the surface of microbes. Despite many years of research, MAC structure and mechanism of action have remained elusive,
Bayly-Jones C, Bubeck D, Dunstone MA.
europepmc   +2 more sources

Novel Selection Approaches to Identify Antibodies Targeting Neoepitopes on the C5b6 Intermediate Complex to Inhibit Membrane Attack Complex Formation [PDF]

Antibodies, 2021
The terminal pathway of complement is implicated in the pathology of multiple diseases and its inhibition is, therefore, an attractive therapeutic proposition. The practicalities of inhibiting this pathway, however, are challenging, as highlighted by the
Lasse Stach, Emily K. H. Dinley, Nadia Tournier, Ryan P. Bingham, Darren A. Gormley, Jo L. Bramhall, Adam Taylor, Jane E. Clarkson, Katherine A. Welbeck, Claire L. Harris, Maria Feeney, Jane P. Hughes, Armin Sepp, Thil D. Batuwangala, Semra J. Kitchen, Eva-Maria Nichols   +15 more
doaj   +2 more sources

Glomerular membrane attack complex is not a reliable marker of ongoing C5 activation in lupus nephritis. [PDF]

Kidney Int, 2019
Complement plays an important role in the pathogenesis of lupus nephritis (LN). With the emergence of therapeutic complement inhibition, there is a need to identify patients in whom complement-driven inflammation is a major cause of kidney injury in LN ...
Wilson HR, Medjeral-Thomas NR, Gilmore AC, Trivedi P, Seyb K, Farzaneh-Far R, Gunnarsson I, Zickert A, Cairns TD, Lightstone L, Cook HT, Pickering MC.   +11 more
europepmc   +2 more sources