Results 41 to 50 of about 710,495 (352)

A unifying mechanism for the biogenesis of membrane proteins co-operatively integrated by the Sec and Tat pathways

eLife, 2017
The majority of multi-spanning membrane proteins are co-translationally inserted into the bilayer by the Sec pathway. An important subset of membrane proteins have globular, cofactor-containing extracytoplasmic domains requiring the dual action of the co-
Fiona J Tooke, Marion Babot, Govind Chandra, Grant Buchanan, Tracy Palmer   +4 more
doaj   +1 more source

Various phenotypes of postpartum atypical hemolytic uremic syndrome: the role of genetic testing in determining prognosis. Case report

Терапевтический архив, 2023
We report a case of atypical hemolytic uremic syndrome (aHUS) that occurred after childbirth in a patient with a history of numerous recurrent episodes of TMA with nephrotic proteinuria and impaired renal function.
Tatiana V. Kirsanova, Alina I. Balakireva, Tatiana A. Fedorova, Aleksei V. Pyregov, Oleg V. Rogachevskiy   +4 more
doaj   +1 more source

Multi-heme Cytochromes in Shewanella oneidensis MR-1:Structures, functions and opportunities [PDF]

, 2015
Multi-heme cytochromes are employed by a range of microorganisms to transport electrons over distances of up to tens of nanometers. Perhaps the most spectacular utilization of these proteins is in the reduction of extracellular solid substrates ...
Brown JP, Collins MJ, Coursolle D, Fonseca BM, Jochen Blumberger, Julea N. Butt, Kevin M. Rosso, Marian Breuer, Song Y, Teixeira M   +9 more
core   +1 more source

Characterization of the Arsenate Respiratory Reductase from Shewanella sp. Strain ANA-3 [PDF]

, 2008
Microbial arsenate respiration contributes to the mobilization of arsenic from the solid to the soluble phase in various locales worldwide. To begin to predict the extent to which As(V) respiration impacts arsenic geochemical cycling, we characterized ...
Keeffe, Jennifer R., Malasarn, Davin, Newman, Dianne K.   +2 more
core   +2 more sources

Tissue factor residues that putatively interact with membrane phospholipids. [PDF]

PLoS ONE, 2014
Blood clotting is initiated by the two-subunit enzyme consisting of the plasma protease, factor VIIa (the catalytic subunit), bound to the integral membrane protein, tissue factor (the regulatory subunit).
Ke Ke, Jian Yuan, James H Morrissey
doaj   +1 more source

Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1

BMC Biology, 2011
Background Ire1 is a signal transduction protein in the endoplasmic reticulum (ER) membrane that serves to adjust the protein-folding capacity of the ER according to the needs of the cell.
Stroud Robert M, Finer-Moore Janet, Korostelev Andrei A, Egea Pascal F, Korennykh Alexei V, Zhang Chao, Shokat Kevan M, Walter Peter   +7 more
doaj   +1 more source

Regulators of complement activity mediate inhibitory mechanisms through a common C3b‐binding mode [PDF]

, 2016
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Atkinson, John P, Bertram, Paula, Forneris, Federico, Granneman, Joke CM, Gros, Piet, Hauhart, Richard, Lambris, John D, Lin, Zhuoer, Liszewski, M. Kathryn, Ricklin, Daniel, Sfyroera, Georgia, Tzekou, Apostolia, Volokhina, Elena, Wu, Jin, Xue, Xiaoguang   +14 more
core   +2 more sources

Implications of Membrane Binding by the Fe-S Cluster-Containing N-Terminal Domain in the Drosophila Mitochondrial Replicative DNA Helicase

Frontiers in Genetics, 2021
Recent evidence suggests that iron-sulfur clusters (ISCs) in DNA replicative proteins sense DNA-mediated charge transfer to modulate nuclear DNA replication.
Minyoung So, Johnny Stiban, Johnny Stiban, Grzegorz L. Ciesielski, Grzegorz L. Ciesielski, Grzegorz L. Ciesielski, Stacy L. Hovde, Laurie S. Kaguni, Laurie S. Kaguni   +8 more
doaj   +1 more source

A C3(H20) recycling pathway is a component of the intracellular complement system [PDF]

, 2017
An intracellular complement system (ICS) has recently been described in immune and nonimmune human cells. This system can be activated in a convertase-independent manner from intracellular stores of the complement component C3. The source of these stores
Botto, Bu, Hrishikesh S. Kulkarni, John P. Atkinson, Liszewski, M. Kathryn Liszewski, Michelle Elvington, Nickells, Paula Bertram, Seya, Singer, Vĕtvicka   +11 more
core   +2 more sources

Demonstration and characterization of CD46, membrane cofactor protein, in stomach.

Japanese Journal of Clinical Immunology, 1996
CD46, membrane cofactor protein, is a glycoprotein widely present on the cell membranes and is different in molecular weight among organs or cells in the same individual. It acts as a cofactor of I of the complement system, which inactivates C3b bound to the autologous cells, and protects them from the attack of the complement.
Seto N, Nakahara R, Shuhei Takemura, Doi T, Kasamatsu Y, Sadanobu Nakanishi, Masayuki Okamoto, Ichio N, Kunio Yanagida, Hideki Onodera, Motoharu Kondo   +10 more
openaire   +4 more sources