Results 41 to 50 of about 177,226 (339)

Atypical hemolytic uremic syndrome

Orphanet Journal of Rare Diseases, 2011
Hemolytic uremic syndrome (HUS) is defined by the triad of mechanical hemolytic anemia, thrombocytopenia and renal impairment. Atypical HUS (aHUS) defines non Shiga-toxin-HUS and even if some authors include secondary aHUS due to Streptococcus pneumoniae
Frémeaux-Bacchi Véronique, Loirat Chantal   +1 more
doaj   +1 more source

CD46 and Oncologic Interactions: Friendly Fire against Cancer

Antibodies, 2020
One of the most challenging aspects of cancer therapeutics is target selection. Recently, CD46 (membrane cofactor protein; MCP) has emerged as a key player in both malignant transformation as well as in cancer treatments.
Michelle Elvington, M. Kathryn Liszewski, John P. Atkinson   +2 more
doaj   +1 more source

Structures and functions of mitochondrial ABC transporters [PDF]

, 2015
A small number of physiologically important ATP-binding cassette (ABC) transporters are found in mitochondria. Most are half transporters of the B group forming homodimers and their topology suggests they function as exporters.
Aller, Ardehali, Balk, Bayeva, Belinda Faust, Bernard, Chen, Chen, Chen, Chitra A. Shintre, Chloupková, Christensen, Csere, Dawson, Dudek, Elisabeth P. Carpenter, Feissner, Giegé, Gompf, Graf, Gutmann, Hendrik W. van Veen, Higgins, Higgins, Hofacker, Hogue, Hyde, Ichikawa, Janneke Balk, Jin, Kessler, Kispal, Kispal, Kiss, Kiss, Krishnamurthy, Krüssel, Kuhnke, Kushnir, Lee, Leighton, Li, Liesa, Lill, Lill, Mikolay, Mitsuhashi, Paterson, Pondarré, Pondarré, Poor, Qi, Rayapuram, San Francisco, Schaedler, Senbongi, Shintre, Shirihai, Srinivasan, Teschner, Theresia A. Schaedler, Tiranti, Tsuchida, Vasundara Srinivasan, Ward, Yamamoto, Young, Zhang   +67 more
core   +2 more sources

The tissue-specific Rep8/UBXD6 tethers p97 to the endoplasmic reticulum membrane for degradation of misfolded proteins.

PLoS ONE, 2011
The protein known as p97 or VCP in mammals and Cdc48 in yeast is a versatile ATPase complex involved in several biological functions including membrane fusion, protein folding, and activation of membrane-bound transcription factors.
Louise Madsen, Franziska Kriegenburg, Andrea Vala, Diana Best, Søren Prag, Kay Hofmann, Michael Seeger, Ian R Adams, Rasmus Hartmann-Petersen   +8 more
doaj   +1 more source

Crystallographic studies of the Escherichia coli quinol-fumarate reductase with inhibitors bound to the quinol-binding site [PDF]

, 2002
The quinol-fumarate reductase (QFR) respiratory complex of Escherichia coli is a four-subunit integral-membrane complex that catalyzes the final step of anaerobic respiration when fumarate is the terminal electron acceptor.
Cecchini, Gary, Croal, Laura R., Iverson, Tina M., Luna-Chavez, César, Rees, Douglas C.   +4 more
core   +1 more source

CD46 (membrane cofactor protein) associates with multiple β1 integrins and tetraspans [PDF]

European Journal of Immunology, 2000
The tetraspans associate with a large number of surface molecules, including a subset of beta1 integrins and, indirectly through CD19, with the complement receptor CD21. To further characterize the tetraspan complexes we have raised and selected monoclonal antibodies (mAb) for their ability to immunoprecipitate a molecule associated with CD9.
Lozahic, Stéphanie, Christiansen, Dale, Manie, Serge, Gerlier, Denis, Billard, Martine, Boucheix, Claude, Rubinstein, Eric   +6 more
openaire   +4 more sources

Vibrio natriegens as Host for Expression of Multisubunit Membrane Protein Complexes

Frontiers in Microbiology, 2018
Escherichia coli is a convenient host for the expression of proteins, but the heterologous production of large membrane protein complexes often is hampered by the lack of specific accessory genes required for membrane insertion or cofactor assembly.
Lena Schleicher, Valentin Muras, Björn Claussen, Jens Pfannstiel, Bastian Blombach, Pavel Dibrov, Günter Fritz, Günter Fritz, Julia Steuber   +8 more
doaj   +1 more source

Identification of the Streptococcal M Protein Binding Site on Membrane Cofactor Protein (CD46) [PDF]

The Journal of Immunology, 2002
AbstractAdherence of group A streptococcus (GAS) to keratinocytes is mediated by an interaction between human CD46 (membrane cofactor protein) with streptococcal cell surface M protein. CD46 belongs to a family of proteins that contain structurally related short consensus repeat (SCR) domains and regulate the activation of the complement components C3b
Giannakis, Eleni, Jokiranta, T. Sakari, Ormsby, Rebecca J., Duthy, Thomas George, Male, Dean Alan, Christiansen, Dale, Fischetti, Vincent A., Bagley, Christopher James, Loveland, Bruce E., Gordon, David L.   +9 more
openaire   +3 more sources

Protein Amphipathic Helix Insertion: A Mechanism to Induce Membrane Fission

Frontiers in Cell and Developmental Biology, 2019
One of the fundamental features of biomembranes is the ability to fuse or to separate. These processes called respectively membrane fusion and fission are central in the homeostasis of events such as those related to intracellular membrane traffic ...
Mikhail A. Zhukovsky, Angela Filograna, Alberto Luini, Daniela Corda, Carmen Valente   +4 more
doaj   +1 more source

Reproductive Characteristic of Transgenic Massachusetts General Hospital Miniature Pigs for Xenotransplantation

Journal of Animal Reproduction and Biotechnology, 2017
Pigs have been extensively used as mediators of xenotransplantation research. Specifically, the Massachusetts General Hospital (MGH) miniature pig was developed to fix major histocompatibility antigens for use in xenotransplantation studies. We generated
Soo-Jeong Ji, Gunsup Lee, Sang Hyoun Park, Kyung Woon Kim, Sung-June Byun, Sun A Ock, Seongsoo Hwang, Jae-Seok Woo, Keon Bong Oh   +8 more
doaj   +1 more source