Results 51 to 60 of about 710,495 (352)

The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations

eLife, 2016
Lamin B receptor (LBR) is a polytopic membrane protein residing in the inner nuclear membrane in association with the nuclear lamina. We demonstrate that human LBR is essential for cholesterol synthesis.
Pei-Ling Tsai, Chenguang Zhao, Elizabeth Turner, Christian Schlieker   +3 more
doaj   +1 more source

Development of α 1,3-galactosyltransferase Inactivated and Human Membrane Cofactor Protein Expressing Homozygous Transgenic Pigs for Xenotransplantation

Journal of Animal Reproduction and Biotechnology, 2017
Transplantation is considered to be a very useful approach to improve human welfare and to prolong life-span. Heterologous organ transplantation using pig organs which are similar to human beings and easy to make mass-production has known as one of the ...
Gunsup Lee, Sang Hyoun Park, Haesun Lee, Soo-Jeong Ji, Joo Yung Lee, Sung-June Byun, Seongsoo Hwang, Kyung Woon Kim, Sun A Ock, Keon Bong Oh   +9 more
doaj   +1 more source

Conformational and mechanical stability of the isolated large subunit of membrane-bound [NiFe]-hydrogenase from Cupriavidus necator

Frontiers in Microbiology, 2023
Comprising at least a bipartite architecture, the large subunit of [NiFe]-hydrogenase harbors the catalytic nickel–iron site while the small subunit houses an array of electron-transferring Fe-S clusters.
Jovan Dragelj, Chara Karafoulidi-Retsou, Sagie Katz, Oliver Lenz, Ingo Zebger, Giorgio Caserta, Sophie Sacquin-Mora, Sophie Sacquin-Mora, Sophie Sacquin-Mora, Maria Andrea Mroginski   +9 more
doaj   +1 more source

Identification of the Streptococcal M Protein Binding Site on Membrane Cofactor Protein (CD46) [PDF]

The Journal of Immunology, 2002
Abstract Adherence of group A streptococcus (GAS) to keratinocytes is mediated by an interaction between human CD46 (membrane cofactor protein) with streptococcal cell surface M protein. CD46 belongs to a family of proteins that contain structurally related short consensus repeat (SCR) domains and regulate the activation of the ...
Giannakis, Eleni, Jokiranta, T. Sakari, Ormsby, Rebecca J., Duthy, Thomas George, Male, Dean Alan, Christiansen, Dale, Fischetti, Vincent A., Bagley, Christopher James, Loveland, Bruce E., Gordon, David L.   +9 more
openaire   +4 more sources

Atypical hemolytic uremic syndrome

Orphanet Journal of Rare Diseases, 2011
Hemolytic uremic syndrome (HUS) is defined by the triad of mechanical hemolytic anemia, thrombocytopenia and renal impairment. Atypical HUS (aHUS) defines non Shiga-toxin-HUS and even if some authors include secondary aHUS due to Streptococcus pneumoniae
Frémeaux-Bacchi Véronique, Loirat Chantal   +1 more
doaj   +1 more source

The Distal Short Consensus Repeats 1 and 2 of the Membrane Cofactor Protein CD46 and Their Distance from the Cell Membrane Determine Productive Entry of Species B Adenovirus Serotype 35

Journal of Virology, 2005
Christoph Fleischli, Sandra Verhaagh, Menzo Havenga, Dominique Sirena, Walter Schaffner, Roberto Cattaneo, Urs F. Greber, Silvio Hemmi   +7 more
openalex   +2 more sources

Functional studies on oligotropha carboxidovorans molybdenum–copper CO dehydrogenase produced in escherichia coli [PDF]

, 2018
The Mo/Cu-dependent CO dehydrogenase (CODH) from Oligotropha carboxidovorans is an enzyme that is able to catalyze both the oxidation of CO to CO2 and the oxidation of H2 to protons and electrons. Despite the close to atomic resolution structure (1.1 Å),
Duffus, Benjamin R., Kaufmann, Paul, Leimkühler, Silke, Teutloff, Christian   +3 more
core   +1 more source

Quantitative analysis of membrane cofactor protein (MCP) of complement. High expression of MCP on human leukemia cell lines, which is down-regulated during cell differentiation.

Journal of Immunology, 1990
Membrane cofactor protein (MCP) is a cell-associated regulatory molecule for C system with C3b/C4b binding and factor I-dependent cofactor activity. mAb were raised against MCP and amounts and distribution examined on normal human cells and cell lines ...
T. Seya, T. Hara, M. Matsumoto, H. Akedo
semanticscholar   +1 more source

The tissue-specific Rep8/UBXD6 tethers p97 to the endoplasmic reticulum membrane for degradation of misfolded proteins.

PLoS ONE, 2011
The protein known as p97 or VCP in mammals and Cdc48 in yeast is a versatile ATPase complex involved in several biological functions including membrane fusion, protein folding, and activation of membrane-bound transcription factors.
Louise Madsen, Franziska Kriegenburg, Andrea Vala, Diana Best, Søren Prag, Kay Hofmann, Michael Seeger, Ian R Adams, Rasmus Hartmann-Petersen   +8 more
doaj   +1 more source

Molecular Studies and an ex vivo Complement Assay on Endothelium Highlight the Genetic Complexity of Atypical Hemolytic Uremic Syndrome: The Case of a Pedigree With a Null CD46 Variant

Frontiers in Medicine, 2020
Atypical hemolytic uremic syndrome (aHUS) is an ultra-rare disease characterized by microangiopathic hemolysis, thrombocytopenia, and renal impairment and is associated with dysregulation of the alternative complement pathway on the microvascular ...
Rossella Piras, Paraskevas Iatropoulos, Elena Bresin, Marta Todeschini, Sara Gastoldi, Elisabetta Valoti, Marta Alberti, Caterina Mele, Miriam Galbusera, Paola Cuccarolo, Ariela Benigni, Giuseppe Remuzzi, Marina Noris   +12 more
doaj   +1 more source