Structure and function of the membrane microdomains in osteoclasts
Bone Research, 2023 The cell membrane structure is closely related to the occurrence and progression of many metabolic bone diseases observed in the clinic and is an important target to the development of therapeutic strategies for these diseases.
Jialong Hou +8 more
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Glycolipids: Linchpins in the Organization and Function of Membrane Microdomains [PDF]
Frontiers in Cell and Developmental Biology, 2020 Membrane microdomains, also called lipid rafts, are areas on membrane enriched in glycolipids, sphingolipids, and cholesterol. Although membrane microdomains are thought to play key roles in many cellular functions, their structures, properties, and ...
Kei Hanafusa +3 more
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Cardiac Hypertrophy Changes Compartmentation of cAMP in Non-Raft Membrane Microdomains
Cells, 2021 3′,5′-Cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger which plays critical roles in cardiac function and disease. In adult mouse ventricular myocytes (AMVMs), several distinct functionally relevant microdomains with tightly ...
Nikoleta Pavlaki +4 more
doaj +1 more source
Spatio-temporal remodeling of functional membrane microdomains organizes the signaling networks of a bacterium. [PDF]
PLoS Genetics, 2015 Lipid rafts are membrane microdomains specialized in the regulation of numerous cellular processes related to membrane organization, as diverse as signal transduction, protein sorting, membrane trafficking or pathogen invasion.
Johannes Schneider +8 more
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Analysis of acid-tolerance mechanism based on membrane microdomains in Saccharomyces cerevisiae
Microbial Cell Factories, 2023 Background Saccharomyces cerevisiae has been used in the biosynthesis of acid products such as organic acids owing to its acid tolerance. Improving the acid tolerance of S. cerevisiae is beneficial for expanding its application range.
Xueqin Lv +9 more
doaj +1 more source
The transmembrane region is responsible for targeting of adaptor protein LAX into "heavy rafts". [PDF]
PLoS ONE, 2012 BACKGROUND: The importance of membrane compartmentalization into specific membrane microdomains has been shown in many biological processes such as immunoreceptor signaling, membrane trafficking, pathogen infection, and tumor progression.
Matous Hrdinka +2 more
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The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains
eLife, 2021 Sigma 1 receptor (S1R) is a 223-amino-acid-long transmembrane endoplasmic reticulum (ER) protein. S1R modulates activity of multiple effector proteins and is a well-established drug target.
Vladimir Zhemkov +6 more
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Biomedicines, 2023 GPCRs receive signals from diverse messengers and activate G proteins that regulate downstream signaling effectors. Efficient signaling is achieved through the organization of these proteins in membranes.
Rafael Álvarez, Pablo V. Escribá
doaj +1 more source
Journal of Lipid Research, 2001 The hypothesis of lipid domains in cellular plasma membranes is well established. However, direct visualization of the domains has been difficult. Here we report direct visualization of plasma membrane cholesterol microdomains modulated by agents that ...
Howard S. Kruth +5 more
doaj +1 more source
Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation. [PDF]
, 2001 Recent studies indicate that insulin stimulation of glucose transporter (GLUT)4 translocation requires at least two distinct insulin receptor-mediated signals: one leading to the activation of phosphatidylinositol 3 (PI-3) kinase and the other to the ...
Chiang, SH +7 more
core +3 more sources