Salmonella effector SopD promotes plasma membrane scission by inhibiting Rab10 [PDF]
Nature Communications, 2021 Salmonella secretes the effector protein SopD into the host cell cytoplasm, leading to scission of the plasma membrane through unclear mechanisms. Here, Boddy et al.
Kirsten C. Boddy +11 more
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Timing of ESCRT-III protein recruitment and membrane scission during HIV-1 assembly [PDF]
eLife, 2018 The Endosomal Sorting Complexes Required for Transport III (ESCRT-III) proteins are critical for cellular membrane scission processes with topologies inverted relative to clathrin-mediated endocytosis.
Daniel S Johnson +2 more
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Bending and Scission: When the Membraneless Condensates Meet Endosome Membrane [PDF]
MedCommZhengkun Zhang, Feng Xie, Long Zhang
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Dynamin recruitment and membrane scission at the neck of a clathrin-coated pit. [PDF]
Mol Biol Cell, 2014 Dynamin, the GTPase required for clathrin-mediated endocytosis, is recruited to clathrin-coated pits in two sequential phases. The first is associated with coated pit maturation; the second, with fission of the membrane neck of a coated pit.
Cocucci E, Gaudin R, Kirchhausen T.
europepmc +3 more sources
ESCRT-III is recruited by human herpesvirus 6A nuclear egress complex to promote nuclear egress of the nucleocapsid [PDF]
Journal of VirologyHerpesviruses replicate their genomes and package them into capsids within the host cell nucleus. These capsids must then translocate from the nucleus to the cytoplasm through a process designated nuclear egress. The virus-encoded nuclear egress complex (
Aila Gulijiahani +5 more
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Salmonella exploits LRRK2-dependent plasma membrane dynamics to invade host cells [PDF]
Nature CommunicationsSalmonella utilizes type 3 secreted effector proteins to induce plasma membrane (PM) perturbations during invasion of host cells1. The effectors drive mobilization of host membranes to generate cell surface ruffles, followed by invagination and scission ...
Hongxian Zhu +11 more
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Programmable DNA shell scaffolds for directional membrane budding [PDF]
Nature CommunicationsIn the pursuit of replicating biological processes at the nanoscale, controlling cellular membrane dynamics has emerged as a key area of interest. Here, we report a system mimicking virus assembly to control directional membrane budding.
Michael T. Pinner, Hendrik Dietz
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The ESCRT Machinery: Remodeling, Repairing, and Sealing Membranes
Membranes, 2022 The ESCRT machinery is an evolutionarily conserved membrane remodeling complex that is used by the cell to perform reverse membrane scission in essential processes like protein degradation, cell division, and release of enveloped retroviruses. ESCRT-III,
Yolanda Olmos
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Domes and cones: Adhesion-induced fission of membranes by ESCRT proteins. [PDF]
PLoS Computational Biology, 2018 ESCRT proteins participate in the fission step of exocytic membrane budding, by assisting in the closure and scission of the membrane neck that connects the nascent bud to the plasma membrane.
Jaime Agudo-Canalejo, Reinhard Lipowsky
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Modelling membrane reshaping by staged polymerization of ESCRT-III filaments.
PLoS Computational Biology, 2022 ESCRT-III filaments are composite cytoskeletal polymers that can constrict and cut cell membranes from the inside of the membrane neck. Membrane-bound ESCRT-III filaments undergo a series of dramatic composition and geometry changes in the presence of an
Xiuyun Jiang +7 more
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