Results 21 to 30 of about 26,711 (229)

Endophilin-A2 functions in membrane scission in clathrin-independent endocytosis. [PDF]

Nature, 2015
During endocytosis, energy is invested to narrow the necks of cargo-containing plasma membrane invaginations to radii at which the opposing segments spontaneously coalesce, thereby leading to the detachment by scission of endocytic uptake carriers. In the clathrin pathway, dynamin uses mechanical energy from GTP hydrolysis to this effect, assisted by ...
Renard HF, Simunovic M, Lemière J, Boucrot E, Garcia-Castillo MD, Arumugam S, Chambon V, Lamaze C, Wunder C, Kenworthy AK, Schmidt AA, McMahon HT, Sykes C, Bassereau P, Johannes L.   +14 more
europepmc   +5 more sources

Membrane scission by the ESCRT-III complex. [PDF]

Nature, 2009
The endosomal sorting complex required for transport (ESCRT) system is essential for multivesicular body biogenesis, in which cargo sorting is coupled to the invagination and scission of intralumenal vesicles. The ESCRTs are also needed for budding of enveloped viruses including human immunodeficiency virus 1, and for membrane abscission in cytokinesis.
Wollert T, Wunder C, Lippincott-Schwartz J, Hurley JH.   +3 more
europepmc   +4 more sources

ATP-dependent force generation and membrane scission by ESCRT-III and Vps4. [PDF]

Science, 2018
AbstractThe ESCRTs catalyze reverse-topology scission from the inner face of membrane necks in HIV budding, multivesicular endosome biogenesis, cytokinesis, and other pathways. We encapsulated a minimal ESCRT module consisting of ESCRT-III subunits Snf7, Vps24, and Vps2, and the AAA+ ATPase Vps4 such that membrane nanotubes reflecting the correct ...
Schöneberg J, Pavlin MR, Yan S, Righini M, Lee IH, Carlson LA, Bahrami AH, Goldman DH, Ren X, Hummer G, Bustamante C, Hurley JH.   +11 more
europepmc   +9 more sources

Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. [PDF]

Proc Natl Acad Sci U S A, 2013
Significance Mitochondrial fission is critical for mammalian cell division, mitophagy, and development. Fission initiates via recruitment of dynamin-related GTPases to the mitochondrial surface. In yeast and human, the recruitment utilizes adaptors that differ in sequence and predicted structure.
Koirala S, Guo Q, Kalia R, Bui HT, Eckert DM, Frost A, Shaw JM.   +6 more
europepmc   +4 more sources

Dynamin: Membrane Scission Meets Physics [PDF]

Current Biology, 2012
Dynamin hydrolyzes GTP to constrict and sever membranes. Experimental advances bring dynamin into the realm of physics and reveal key roles for membrane tension and bending at the edge of the constriction.
Hurley, James H., Hinshaw, Jenny E.
openaire   +2 more sources

ESCRT membrane scission revealed by optical tweezers. [PDF]

The FASEB Journal, 2018
ESCRT proteins catalyze the function of membrane budding and scission from the inside of the cytosol to the outside. This process is fundamental in cell biology, comprising multivesicular endosome biogenesis, cytokinesis, viral budding (e.g. HIV, Ebola, Dengue) and other pathways.
Johannes Schöneberg, Shannon Yan, Amir Bahrami, Maurizio Righini, Il-Hyung Lee, Mark Remec Pavlin, Lars-Anders Carlson, Daniel Goldman, Gerhard Hummer, Carlos Bustamante, James Hurley   +10 more
openaire   +1 more source

A new role for myosin II in vesicle fission. [PDF]

PLoS ONE, 2014
An endocytic vesicle is formed from a flat plasma membrane patch by a sequential process of invagination, bud formation and fission. The scission step requires the formation of a tubular membrane neck (the fission pore) that connects the endocytic ...
Juan A Flores, Santiago Balseiro-Gomez, Jose M Cabeza, Jorge Acosta, Pilar Ramirez-Ponce, Eva Ales   +5 more
doaj   +1 more source

When in Need of an ESCRT: The Nature of Virus Assembly Sites Suggests Mechanistic Parallels between Nuclear Virus Egress and Retroviral Budding

Viruses, 2021
The proper assembly and dissemination of progeny virions is a fundamental step in virus replication. As a whole, viruses have evolved a myriad of strategies to exploit cellular compartments and mechanisms to ensure a successful round of infection.
Kevin M. Rose, Stephanie J. Spada, Vanessa M. Hirsch, Fadila Bouamr   +3 more
doaj   +1 more source

Lipid accumulation controls the balance between surface connection and scission of caveolae

eLife, 2020
Caveolae are bulb-shaped invaginations of the plasma membrane (PM) that undergo scission and fusion at the cell surface and are enriched in specific lipids.
Madlen Hubert, Elin Larsson, Naga Venkata Gayathri Vegesna, Maria Ahnlund, Annika I Johansson, Lindon WK Moodie, Richard Lundmark   +6 more
doaj   +1 more source

Determinants of endocytic membrane geometry, stability, and scission [PDF]

Proceedings of the National Academy of Sciences, 2011
During endocytic vesicle formation, distinct subdomains along the membrane invagination are specified by different proteins, which bend the membrane and drive scission. Bin-Amphiphysin-Rvs (BAR) and Fer-CIP4 homology-BAR (F-BAR) proteins can induce membrane curvature and have been suggested to facilitate membrane invagination and scission.
Takuma, Kishimoto, Yidi, Sun, Christopher, Buser, Jian, Liu, Alphée, Michelot, David G, Drubin   +5 more
openaire   +2 more sources