Uncovering the Mechanisms of Intracellular Membrane Trafficking by Reconstituted Membrane Systems [PDF]
MembranesIntracellular membrane trafficking that transports proteins, lipids, and other substances between organelles is crucial for maintaining cellular homeostasis and signal transduction. The imbalance of membrane trafficking leads to various diseases.
Shuhan Chen, Yinghui Liu, Haijia Yu
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Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism
Nature Communications, 2023 Phospholipase D3 (PLD3) polymorphisms are linked to late-onset Alzheimer’s disease (LOAD). Being a lysosomal 5’-3’ exonuclease, its neuronal substrates remained unknown as well as how a defective lysosomal nucleotide catabolism connects to AD ...
Zoë P. Van Acker +11 more
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Structure of the bacterial flagellar hook cap provides insights into a hook assembly mechanism
Communications Biology, 2021 Matsunami et al determine the structure of the flagellar hook cap from Salmonella enterica by X-ray crystallography. The 3.3 Å resolution structure in combination with mutagenesis analysis provides insights into a putative hook assembly mechanism.
Hideyuki Matsunami +4 more
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VAMP5 and distinct sets of cognate Q-SNAREs mediate exosome release
Cell Structure and Function, 2023 Small extracellular vesicles (sEVs) are largely classified into two types, plasma-membrane derived sEVs and endomembrane-derived sEVs. The latter type (referred to as exosomes herein) is originated from late endosomes or multivesicular bodies (MVBs).
Takahide Matsui +3 more
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Deep and fast label-free Dynamic Organellar Mapping
Nature Communications, 2023 The Dynamic Organellar Maps (DOMs) approach combines cell fractionation and shotgun-proteomics for global profiling analysis of protein subcellular localization.
Julia P. Schessner +4 more
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Editorial overview: Membrane trafficking [PDF]
Current Opinion in Cell Biology, 2019 [No Abstract]
Cullen, Peter J., Nakano, Akihiko
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The endocytic pathway taken by cationic substances requires Rab14 but not Rab5 and Rab7
Cell Reports, 2021 Summary: Endocytosis and endosome dynamics are controlled by proteins of the small GTPase Rab family. Besides possible recycling routes to the plasma membrane and various organelles, previously described endocytic pathways (e.g., clathrin-mediated ...
Evgeniya Trofimenko +3 more
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Multiple Domains in the Kv7.3 C-Terminus Can Regulate Localization to the Axon Initial Segment
Frontiers in Cellular Neuroscience, 2020 The voltage-gated Kv7.2/Kv7.3 potassium channel is a critical regulator of neuronal excitability. It is strategically positioned at the axon initial segment (AIS) of neurons, where it effectively inhibits repetitive action potential firing.
Louise Leth Hefting +4 more
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Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors
Molecular Neurodegeneration, 2019 Increasing evidence supports that cellular dysregulations in the degradative routes contribute to the initiation and progression of neurodegenerative diseases, including Alzheimer’s disease.
Zoë P. Van Acker +2 more
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Crossroads between membrane trafficking machinery and copper homeostasis in the nerve system
Open Biology, 2021 Imbalanced copper homeostasis and perturbation of membrane trafficking are two common symptoms that have been associated with the pathogenesis of neurodegenerative and neurodevelopmental diseases.
Meng-Hsuan Wen +4 more
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