Results 111 to 120 of about 3,014,380 (256)

Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD

Scientific Reports, 2016
The methylerythritol phosphate (MEP) pathway is an essential metabolic pathway found in malaria parasites, but absent in mammals, making it a highly attractive target for the discovery of novel and selective antimalarial therapies.
K. E. Price, Christopher M. Armstrong, L. Imlay, Dana M. Hodge, C. Pidathala, Natalie Roberts, Jooyoung Park, Marwa O. Mikati, Raman Sharma, Alexandre S. Lawrenson, N. Tolia, N. Berry, P. O’Neill, A. O. John   +13 more
semanticscholar   +1 more source

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

Tracing the biosynthetic origin of limonoids and their functional groups through stable isotope labeling and inhibition in neem tree (Azadirachta indica) cell suspension

BMC Plant Biology, 2018
Background Neem tree serves as a cornucopia for triterpenoids called limonoids that are of profound interest to humans due to their diverse biological activities.
Thiagarayaselvam Aarthy, Fayaj A. Mulani, Avinash Pandreka, Ashish Kumar, Sharvani S. Nandikol, Saikat Haldar, Hirekodathakallu V. Thulasiram   +6 more
doaj   +1 more source

Robust causal structure learning with some hidden variables

, 2018
We introduce a new method to estimate the Markov equivalence class of a directed acyclic graph (DAG) in the presence of hidden variables, in settings where the underlying DAG among the observed variables is sparse, and there are a few hidden variables ...
Frot, Benjamin, Maathuis, Marloes H., Nandy, Preetam   +2 more
core   +1 more source

Statistically Significant Strings are Related to Regulatory Elements in the Promoter Regions of Saccharomyces cerevisiae [PDF]

, 2000
Finding out statistically significant words in DNA and protein sequences forms the basis for many genetic studies. By applying the maximal entropy principle, we give one systematic way to study the nonrandom occurrence of words in DNA or protein ...
Bin Wang, Burge, Derisi, Goffeau, Helden, Hertz, Hinnebusch, Honerkamp, Lawrence, Li, Mantegna, Peng, Pevzer, Phillips, Rui Hu, Shannon, Zhang, Zhu   +17 more
core   +2 more sources

Spontaneous Perovskite Passivator Featuring Dual Functional Groups

Advanced Energy Materials, EarlyView.
A novel strategy to suppress multiple defect sites in perovskite crystals using a spontaneous passivator with dual functional groups is proposed, addressing an intrinsic drawback of conventional spontaneous perovskite passivators. 2‐thiophene‐ethyl‐ammonium‐bis(trifluoromethylsulfonyl)imide (TEA‐TFSI) is newly synthesized and successfully demonstrate ...
Naoyuki Nishimura, Yoyo Hinuma, Hiroyuki Kanda, Kohei Yamamoto, Hideyuki Takada, Masaki Yumoto, Daniela Serien, Kenichi Tashiro, Aiko Narazaki, Takurou N. Murakami   +9 more
wiley   +1 more source

Psychological and immunological associations with movement-evoked low back pain among older adults

PAIN Reports
. Introduction:. Low back pain (LBP) is a leading global factor in disability among older adults. Movement-evoked pain (MEP) is potentially an important mediator in the disability pathway but is predominantly tested in the laboratory. Objectives:.
Riley Kahan, Arthur Woznowski-Vu, Janet L. Huebner, Carl F. Pieper, Adam P. Goode, Steven Z. George, Timothy H. Wideman, Virginia Byers Kraus, Cathleen Colón-Emeric, Corey B. Simon   +9 more
doaj   +1 more source

MusicSwarm: Biologically Inspired Intelligence for Music Composition

Advanced Intelligent Systems, EarlyView.
Biologically inspired swarms of frozen foundation models self‐organize to compose complex music without fine‐tuning. By coordinating through stigmergic signals, decentralized agents dynamically evolve specialized roles and adapt to solve complex tasks.
Markus J. Buehler
wiley   +1 more source

A Specific Process to Purify 2-Methyl-D-Erythritol-4-Phosphate Enzymatically Converted from D-Glyceraldehyde-3-Phosphate and Pyruvate

Natural Product Communications, 2015
A one-pot enzymatic cascade was established to synthesize MEP, one of the key intermediates in the MEP terpenoid biosynthetic pathway. D-GAP and sodium pyruvate were converted to MEP in a reaction catalyzed by DXP synthase and DXP reductoisomerase (DXR ...
Shao-Qing Yang, Jian Deng, Qian-Qian Wu, Heng Li, Wen-Yun Gao   +4 more
doaj   +1 more source

Transcriptome profiling of spike provides expression features of genes related to terpene biosynthesis in lavender

Scientific Reports, 2020
Lavender (Lavandula angustifolia) is an important economic plant because of the value of its essential oil (EO). The Yili Valley in Xinjiang has become the largest lavender planting base in China.
Danli Guo, Kaicheng Kang, Pu Wang, Min Li, Xianzhong Huang   +4 more
doaj   +1 more source