Results 111 to 120 of about 16,979 (233)
Histiocytosis development and clinical variation through the lens of genomics
The Journal of Pathology, EarlyView.Abstract Histiocytic neoplasms are rare haematologic diseases characterised by clonal expansions of cells with a monocyte, macrophage or dendritic cell phenotype. Their clinical manifestations are diverse, ranging from indolent lesions to aggressive systemic disease.
Paul G Kemps +3 more
wiley +1 more source
The Design, Synthesis, and Evaluation of inhibitors of The ISPF Enzyme in The MEP Pathway
, 2019 Isoprenoids are a class of over 50,000 compounds that serve as key precursors for many compounds in plants and animals. These compounds play critical roles in many biological functions such as cellular growth, respiration, and go on to form critical ...
Stewart, Christopher G.
core
New Frontiers in EU Trade Policy: Moving Beyond Conventional Trade Agreements
Global Policy, EarlyView.ABSTRACT As the rules‐based international trading system faces stagnation and increasing unilateralism, the European Union's trade policy must evolve beyond conventional free trade agreements (FTAs). This article examines recent trends in EU trade agreements, highlighting not only their expanded scope to include areas such as digital trade ...
Niall Moran
wiley +1 more source
Cancer Science, EarlyView.An immune dysfunction score (IDS) provides independent prognostic information in MDS and CMML, complements current risk models, mirrors disease changes, and reflects underlying immune impairment. IDS may also highlight therapeutic sensitivities, supporting its use as a practical biomarker for risk stratification and clinical follow‐up.
Yu‐Hung Wang +16 more
wiley +1 more source
Pharmaceutical Biology, 2019 Context: Salvia miltiorrhiza Bunge (Labiatae) is a traditional Chinese herb. Endophytic fungi, which are biotic elicitors, can induce accumulation of secondary metabolites in their host plants.
Yan Jiang +6 more
doaj +1 more source
Hydroxymethylbutenyl diphosphate accumulation reveals MEP pathway regulation for high CO2-induced suppression of isoprene emission. [PDF]
Proc Natl Acad Sci U S A, 2023 Sahu A +3 more
europepmc +1 more source
Mechanisms of Thrombocytosis in Iron‐Deficiency Anemia
European Journal of Haematology, EarlyView.ABSTRACT Iron‐deficiency anemia is frequently accompanied by reactive thrombocytosis, yet the mechanisms underlying this association remain incompletely understood. Beyond impaired erythropoiesis, iron availability has emerged as an active regulator of hematopoietic lineage decisions.
João Vitor Facco +2 more
wiley +1 more source
Targeting MEP pathway for the development of antitubercular drugs
, 2022 Thesis (MSc)--Stellenbosch University, 2022.ENGLISH ABSTRACT: Background: Tuberculosis (TB) still remains a global health burden with an estimated 1.4 million mortalities in 2019.
Maila, Tumelo
core
JCMS: Journal of Common Market Studies, EarlyView.Abstract The Anti‐Coercion Instrument (ACI), the most powerful tool in the EU's geoeconomic arsenal, has its origins in the first Trump US presidency and has recently been brandished again as a potential response to Trump's coercive tariffs. Its centrality to the EU's ‘geoeconomic turn’ and the twists and turns of its legislative history have been ...
Jaša Veselinovič
wiley +1 more source
HDR, the last enzyme in the MEP pathway, differently regulates isoprenoid biosynthesis in two woody plants. [PDF]
Plant Physiol, 2023 Krause T +9 more
europepmc +1 more source