Histiocytosis development and clinical variation through the lens of genomics
Abstract Histiocytic neoplasms are rare haematologic diseases characterised by clonal expansions of cells with a monocyte, macrophage or dendritic cell phenotype. Their clinical manifestations are diverse, ranging from indolent lesions to aggressive systemic disease.
Paul G Kemps +3 more
wiley +1 more source
Supramolecular Host‐Guest Complexation Dynamics by Cost‐Efficient Electronic Structure Methods
We present a cost‐effective multilevel workflow for the kinetic profiling of host–guest systems, illustrated with cucurbit[6]uril and alkylammonium cations. The method combines rapid docking and reaction path searches at the semi‐empirical level, with refinement of the results using modern density functional theory, accurately reproducing experiment ...
Thomas Gasevic +6 more
wiley +1 more source
Reconstituted ferredoxin-MEP pathway of Apicomplexa in Escherichiacoli as an in situ screening platform for inhibitors and essential enzyme mutations. [PDF]
Akuh OA +4 more
europepmc +1 more source
The organ-specific differential roles of rice DXS and DXR, the first two enzymes of the MEP pathway, in carotenoid metabolism in Oryza sativa leaves and seeds. [PDF]
You MK +6 more
europepmc +1 more source
Objective There is growing evidence that knee osteoarthritis (OA), a significant source of chronic pain, is only partly explained by joint pathophysiology, varies significantly between individuals and may be partly driven by changes in periarticular tissues.
Alisa J. Johnson +2 more
wiley +1 more source
NbHDR, A Host Protein Involved in the MEP Pathway, Interacts With Bamboo Mosaic Virus Replicase and Enhances Viral Accumulation. [PDF]
Wong CH +6 more
europepmc +1 more source
A biomimetic aerogel conduit was engineered from a nanofiber of gelatin/poly(l‐lactic acid) doped with polypyrrole nanoparticles, integrated with tannic acid and Mg2+. This “electro‐ionic‐immune” strategy mimicked spinal cord properties, reduced calcium overload, inflammation, oxidative damage, promoted neural stem cell differentiation, suppressed ...
Qingxiang Liu +9 more
wiley +1 more source
The chromosome-scale genomes of two Tinospora species reveal differential regulation of the MEP pathway in terpenoid biosynthesis. [PDF]
Chen Z +9 more
europepmc +1 more source
A soft–hard tri‐layer composite electrolyte that couples fast Li+ transport with reinforced interfacial stability to enable high‐conductivity, mechanically robust, dendrite‐free lithium‐metal batteries. ABSTRACT The development of solid polymer electrolytes is central to safe, high‐energy lithium‐metal batteries (LMBs); however, persistent challenges ...
Fazal Ur Rehman +9 more
wiley +1 more source

