Results 121 to 130 of about 3,014,380 (256)

Mechanisms for the Increased Fatigability of the Lower Limb in People with Type 2 Diabetes [PDF]

, 2018
Fatiguing exercise is the basis of exercise training and a cornerstone of management of type 2 diabetes mellitus (T2D), however, little is known about the fatigability of limb muscles and the involved mechanisms in people with T2D.
Harkins, April, Harmer, Alison R, Hunter, Sandra K., Magill, Steven B., Senefeld, Jonathon   +4 more
core   +2 more sources

A novel mouse model simulating C5 palsy after cervical surgery

Animal Models and Experimental Medicine, EarlyView.
This study establishes a reliable mouse model of permanent C5 palsy (post‐laminectomy complication) via dorsal approach, selectively severing the C5 anterior nerve root while preserving the posterior root through partial C4 and C5 laminectomy. The model successfully replicates clinical C5P features—flaccid shoulder paralysis, electrophysiological ...
Chenpei Xu, Xianghe Wang, Mingjie Zhou, Chuxiang Chen, Tingzheng Jiang, Fei Wang, Kaixiang Yang, Hongli Wang, Su Jiang   +8 more
wiley   +1 more source

String Method for the Study of Rare Events

, 2002
We present a new and efficient method for computing the transition pathways, free energy barriers, and transition rates in complex systems with relatively smooth energy landscapes. The method proceeds by evolving strings, i.e.
A. Michalak, C. Dellago, C. Dellago, D. Passerone, D. V. Berkov, Eric Vanden-Eijnden, G. Henkelman, H.-B. Braun, H.-B. Braun, H.-B. Braun, I. V. Ionova, P. Hänggi, R. Olender, R. Olender, R. P. Cowburn, Weinan E, Weiqing Ren   +16 more
core   +1 more source

Minimum energy paths for conformational changes of viral capsids [PDF]

, 2017
In this work we study how a viral capsid can change conformation using techniques of Large Deviations Theory for stochastic differential equations. The viral capsid is a model of a complex system in which many units - the proteins forming the capsomers -
Cermelli, Paolo, Indelicato, Giuliana, Zappa, Emilio   +2 more
core   +2 more sources

USB1 deficiency disrupts neutrophil maturation via RNA dysregulation independent of global pre‐mRNA splicing

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the essential role of USB1 in neutrophil maturation. In normal myeloid cells, USB1 acts as an RNA exonuclease, trimming RNA tails to maintain proper RNA network function, which supports the differentiation of myeloid progenitor cells into mature neutrophils.
Hang Li, Guiying Shi, Jiaming Tang, Yiying Huang, Jie Wang, Xuepei Lei, Lin Bai   +6 more
wiley   +1 more source

Impaired transmission in the corticospinal tract and gait disability in spinal cord injured persons [PDF]

, 2010
Rehabilitation following spinal cord injury is likely to depend on recovery of corticospinal systems. Here we investigate whether transmission in the corticospinal tract may explain foot drop (inability to dorsiflex ankle) in persons with spinal cord ...
Barthélemy, Dorothy, Barthélemy, Dorothy, Biering-Sørensen, Fin, Biering-Sørensen, Fin, Conway, Bernard A, Conway, Bernard A., Holm-Nielsen, Jens Bo, Knudsen, Hanne, Knudsen, Hanne, Lundell, Hans Magnus Henrik, Lundell, Henrik, Nielsen, Jens Bo, Willerslev-Olsen, Maria, Willerslev-Olsen, Maria   +13 more
core   +1 more source

Multimodal Chromatography in the Downstream Processing of mAb‐Based Products: Mechanisms, Strategies, and Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Multimodal chromatography has emerged as a powerful tool for the purification of monoclonal antibodies (mAbs) and their derivatives—including antibody fragments (Fabs), Fc‐fusions, bispecific (BsAb), and antibody–drug conjugates (ADCs)—offering enhanced selectivity through the integration of ionic, hydrophobic, hydrogen‐bonding, and π–π ...
Amin Javidanbardan, Marco P․ C․ Marques, Ana M. Azevedo, Daniel G. Bracewell, Stephen Goldrick   +4 more
wiley   +1 more source

Constraint methods for determining pathways and free energy of activated processes

, 2011
Activated processes from chemical reactions up to conformational transitions of large biomolecules are hampered by barriers which are overcome only by the input of some free energy of activation.
A. Sergi, A.E. Cardenas, A.E. Mark, C. Burisch, C. Dellago, C. Ghio, D. Trzesniak, D.P. Geerke, E. Darve, E. Di Pietro, E. Fois, E. Fois, E. Fois, E.A. Carter, F. Molnar, G. Ciccotti, G.M. Torrie, H. Frauenfelder, H. Frauenfelder, H. Grubmuller, J. Ma, J. Schlitter, J. Schlitter, J. Schlitter, J. Schlitter, J. Schlitter, J.F. Diaz, J.F. Diaz, J.M. Depaepe, J.P. Ma, J.P. Ma, J.P. Ma, M. Fixman, M. Klaehn, M. Semialjac, M. Sprik, M.A. Kastenholz, N.L. Doltsinis, P. Ferrara, P. Ferrara, P. Kruger, P.R.L. Markwick, R. Elber, R. Elber, S. Fischer, S. Stepaniants, S.R. Billeter, S.Y. Yang, S.Y. Yang, T. Mulders, T.C. Flynn, W. Swegat, W.K. Den, W.K. Den   +53 more
core   +1 more source

Elucidating the NuclearQuantum Dynamics of Intramolecular Double Hydrogen Transfer in Porphycene [PDF]

, 2019
We address the double hydrogen transfer (DHT) dynamics of the porphycene molecule: A complex paradigmatic system where the making and breaking of H-bonds in a highly anharmonic potential energy surface requires a quantum mechanical treatment not only of ...
Kumagai, Takashi, Litman, Yair, Richardson, Jeremy O., Rossi, Mariana   +3 more
core   +3 more sources

Feedback regulation of the methylerythritol 4-phosphate (MEP) pathway

, 2022
Los isoprenoides son una de las familias más grandes de metabolitos y tienen un gran interés en las industrias farmacéutica, de biocombustibles y agroalimentaria. Todos los isoprenoides derivan del difosfato de isopentenilo (IPP) y su isómero de doble enlace altamente electrofílico difosfato de dimetilalilo (DMAPP). IPP y DMAPP se derivan de la vía del
openaire   +3 more sources