Results 141 to 150 of about 15,771 (216)

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, Volume 13, Issue 44, 7 August 2026.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

Mapping Steroidogenic Perturbations Under Endocrine Disruptor Mixtures Across Demographic Subgroups: Structural and Metabolomic Insights

Advanced Science, Volume 13, Issue 46, 17 August 2026.
Population‐scale EDC–hormone association mapping among 4255 participants across demographic subgroups identifies phthalate metabolites as the most consistent signals associated with lower testosterone‐related markers in males. Integrative mechanistic validation prioritizes MCPP as a key phthalate metabolite linked to CYP17A1‐centered disruption of ...
Yanling Chen, Lei Huang, Yingtong Jiang, Guohong Zhao, Mengyuan Zhu, Xiulian Lu, Lang Lang, Akinpelumi Oluwatobiloba Esther, Longhao Fan, Yuqi Jiang, Chang Sun, Xiaoling Zhang, Kun Zhou, Xiaoming Ji, Minjian Chen   +14 more
wiley   +1 more source

Acute and Chronic Effects of Aerobic Exercise on Motor Inhibition and Cortical Excitability in Adolescents With Attention Deficit Hyperactivity Disorder

Brain and Behavior, Volume 16, Issue 8, August 2026.
In adolescents with ADHD, acute and chronic aerobic exercise enhance motor inhibition. Chronic exercise yields greater benefits and reduces cortical excitability, linking behavioral gains to neurophysiological changes. These findings support sustained exercise as a therapeutic strategy for improving inhibitory control.
Jia‐Ling Sun, Jung‐Chi Chang, Pou‐Leng Cheong, Hsiao‐I Kuo   +3 more
wiley   +1 more source

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, Volume 101, Issue 4, Page 1662-1682, August 2026.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source

Recombinant Artemin‐Fc Fusion Protein Attenuates TLR4/NF‐κB‐Associated Neuroinflammation and Modulates Inhibitory/Excitatory Synaptic Marker Expression After Spinal Cord Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Intrathecal ARTN‐Fc treatment attenuates TLR4/NF‐κB‐associated neuroinflammation, promotes microglia/macrophage polarization towards an anti‐inflammatory phenotype, and improves functional recovery after spinal cord injury. ARTN‐Fc also modulates inhibitory/excitatory synaptic marker expression in the L4–L5 spinal dorsal horn, which may contribute to ...
Wenjie Lu, Yurong Tu, Renkai Wang, Minghao Jiang, Junyu Zhuang, Jiahui Song, Ping Wu, Sunren Sheng, Sipin Zhu, Zhouguang Wang   +9 more
wiley   +1 more source

The MEP pathway in Babesia orientalis apicoplast, a potential target for anti-babesiosis drug development. [PDF]

Parasit Vectors, 2018
He L, He P, Luo X, Li M, Yu L, Guo J, Zhan X, Zhu G, Zhao J.   +8 more
europepmc   +1 more source

Integrated Metabolomic and Transcriptomic Analysis Revealed the Capsanthin Biosynthesis and Sequestration in Processing Type Red Pepper (Capsicum annuum var. conoides)

eFood, Volume 7, Issue 4, August 2026.
This study establishes that fruit color divergence in Yanjiao pepper cultivars arises from hierarchical regulation of carotenoid metabolism, driven by yellow‐blue chromaticity variation and cultivar‐specific metabolic strategies. These findings provide a mechanistic framework for breeding peppers with enhanced color stability and nutraceutical value ...
Qi Chen, Ming Wang, Minjie Duan, Youjin Hao, Jian Ming, Honghai Li   +5 more
wiley   +1 more source

Impact of cenobamate on cortical responses to transcranial magnetic stimulation in people with drug‐resistant focal epilepsy

Epilepsia Open, Volume 11, Issue 4, Page 1171-1183, August 2026.
Abstract Objective Cenobamate (CNB) is an effective antiseizure medication, though its mechanisms of efficacy remain incompletely understood. We assessed changes in cortical responses to transcranial magnetic stimulation (TMS) following CNB treatment.
Silvano R. Gefferie, Diego Jiménez‐Jiménez, Gerhard H. Visser, Robert M. Helling, Arn M. J. M. van den Maagdenberg, Josemir W. Sander, Simona Balestrini, Roland D. Thijs   +7 more
wiley   +1 more source

Spatiotemporal Brain Dynamics of Transitive and Intransitive Action Observation

Human Brain Mapping, Volume 47, Issue 11, 01 August 2026.
In the present study, we demonstrate that observing transitive and intransitive movements engages the Action Observation Network through shared circuits, which are expressed with distinct spatiotemporal gradients. Whole‐brain EEG cluster‐based and microstate analyses revealed differential anterior and posterior dynamics around 200 and 350 ms from ...
Giacomo Guidali, Eleonora Arrigoni, Angelo Maravita, Alberto Pisoni, Nadia Bolognini   +4 more
wiley   +1 more source

Metabolic and transcriptional analyses in response to potent inhibitors establish MEP pathway as major route for camptothecin biosynthesis in Nothapodytes nimmoniana (Graham) Mabb. [PDF]

BMC Plant Biol, 2019
Rather GA, Sharma A, Jeelani SM, Misra P, Kaul V, Lattoo SK.   +5 more
europepmc   +1 more source