Unravelling the regulatory mechanisms that modulate the MEP pathway in higher plants [PDF]
The methyl-D-erythritol 4-phosphate pathway is responsible for the biosynthesis of a substantial number of natural compounds of biological and biotechnological importance. In recent years, this pathway has become an obvious target to develop new herbicides and antimicrobial drugs.
Mari Salmi +2 more
exaly +3 more sources
Probable Novel MEP Pathway Inhibitor and Its Binding Protein, IspG
A second isoprene unit biosynthetic pathway, via 2-C-methyl-D-erythritol 4-phosphate (MEP), was discovered in the 1990s. We screened and isolated the cyclic dipeptide, maculosin, which is a probable novel MEP pathway inhibitor, from the culture broth of Bacillus subtilis strain KN07.
Kentaro Takada
exaly +3 more sources
Related searches:
The plastidial MEP pathway: unified nomenclature and resources
Trends in Plant Science, 2008In plants, the plastid-localized 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway provides the precursors for the synthesis of isoprenoid hormones, monoterpenes, carotenoids and the side chain of chlorophylls, tocopherols and prenylquinones. As a result of the fast progress in the elucidation and characterization of the pathway (mainly by genetic ...
Phillips, Michael +3 more
openaire +3 more sources
Methylerythritol 4-phosphate (MEP) pathway metabolic regulation
Nat. Prod. Rep., 2014The methylerythritol 4-phosphate pathway provides precursors for isoprenoids in bacteria, some eukaryotic parasites, and chloroplasts of plants. Metabolic regulatory mechanisms control flux through the pathway and the concentration of a central intermediate, methylerythritol cyclodiphosphate.
A, Banerjee, T D, Sharkey
openaire +2 more sources
Phosphomevalonate kinase regulates the MVA/MEP pathway in mango during ripening
Plant Physiology and Biochemistry, 2023Mango is a popular tropical fruit with a great diversity in taste and aroma, contributed primarily by terpenoids. Phosphomevalonate kinase (PMK) is a key enzyme for isoprenoid biosynthesis in the mevalonic acid (MVA) pathway responsible for terpenoids.
Garima Pathak +5 more
openaire +2 more sources
Network Analysis of the MVA and MEP Pathways for Isoprenoid Synthesis
Annual Review of Plant Biology, 2013Isoprenoid biosynthesis is essential for all living organisms, and isoprenoids are also of industrial and agricultural interest. All isoprenoids are derived from prenyl diphosphate (prenyl-PP) precursors. Unlike isoprenoid biosynthesis in other living organisms, prenyl-PP, as the precursor of all isoprenoids in plants, is synthesized by two ...
Eva Vranová +2 more
openaire +3 more sources
Engineering the
AbstractThe 2‐C‐methyl‐D‐erythritol‐4‐phosphate (MEP) pathway genes encoding DXR and MECS from Taxus species and STR from Catharanthus roseus were used to genetically modify the ajmalicine biosynthetic pathway in hairy root cultures of C. roseus. As expected, the STR‐overexpressed root cultures showed twofold higher accumulation of ajmalicine than the ...
Kai, Chang +8 more
openaire +2 more sources
Mathematical modelling of the diurnal regulation of the
Summary Isoprenoid molecules are essential elements of plant metabolism. Many important plant isoprenoids, such as chlorophylls, carotenoids, tocopherols, prenylated quinones and hormones are synthesised in chloroplasts via the 2‐C‐methyl‐d‐erythritol 4‐phosphate (MEP) pathway.
Alexandra Pokhilko +4 more
openaire +3 more sources
Combinational biosynthesis of isoprene by engineering the MEP pathway in Escherichia coli
Process Biochemistry, 2014Abstract As an important feedstock in petrochemistry, isoprene is used in a wide range of industrial applications. It is produced almost entirely from petrochemical sources; however, these sources are being progressively depleted. A reliable biological process for isoprene production utilizing renewable feedstocks would be an industry-redefining ...
Chun-Li Liu, Luo Liu, Li-Hai Fan
exaly +2 more sources
SlWRKY35 positively regulates carotenoid biosynthesis by activating the MEP pathway in tomato fruit
New Phytologist, 2022Summary Carotenoids are vital phytonutrients widely recognised for their health benefits. Therefore, it is vital to thoroughly investigate the metabolic regulatory network underlying carotenoid biosynthesis and accumulation to open new leads towards improving their contents in vegetables and crops.
Yuan, Yong +12 more
openaire +4 more sources

