Results 181 to 190 of about 1,149,764 (218)

Crystal structure of IspF from Bacillus subtilis and absence of protein complex assembly amongst IspD/IspE/IspF enzymes in the MEP pathway. [PDF]

Biosci Rep, 2018
Liu Z, Jin Y, Liu W, Tao Y, Wang G.
europepmc   +1 more source

A Blood–Brain Barrier‐Permeable Guanylhydrazone Analogue of the ASIC3 Activator GMQ Inhibits Human Glioblastoma Stem Cell Growth In Vitro

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
The acid‐sensing ion channel 3 (ASIC3), physiologically located in the peripheral nervous system, was found in stem cells of CNS‐located glioblastoma multiforme (GBM CSCs); its chronic activation in the CNS kills dysfunctional GBM CSCs with no effect on ASIC3‐lacking CNS tissues.
Leonardo Maiorana, Nicoletta Collura, Andrea Gotti, Giulia De Leonardis, Greta Donati, Alice Maiocchi, Luciana Marinelli, Andrea Menegon, Pierfausto Seneci   +8 more
wiley   +1 more source

Diarylethene‐Containing Photoswitchable Analogues of Tubulysins—Design, Synthesis, Biological, and Structural Evaluation

European Journal of Organic Chemistry, Volume 29, Issue 35, 19 September 2026.
Diarylethene‐containing cyclic tubulysin analogues were designed, synthesized, and evaluated as light‐responsive cytotoxic agents. One analogue showed reversible photoswitching, photoregulated tubulin polymerization inhibition, and photoform‐dependent cytotoxicity.
Anna Iampolska, Sergii Afonin, Oleg Babii, Mahri Park, Juan Estévez‐Gallego, Michel O. Steinmetz, Andrea E. Prota, Anne S. Ulrich, David R. Spring, Igor V. Komarov   +9 more
wiley   +1 more source

Breaking the Ceiling of Boron‐Boron Bonds: Understanding and Fine‐Tuning Basicity in Diborane(4) Complexes

Journal of Computational Chemistry, Volume 47, Issue 24, September 15, 2026.
Diborane(4) can form strong complexes with one or two nitrogen bases, and still behave as a boron base. Complexed with two nitrogen bases, diborane(4) may reach very high proton affinities, overcoming that of the typical 1,8‐bis(dimethylamino)naphthalene super sponge. However, understanding basicity trends is not straightforward, due to the loss of the
Manuel Yáñez, Otilia Mó, M. Merced Montero‐Campillo, Ibon Alkorta   +3 more
wiley   +1 more source

Enhancing Geranylgeranyl Pyrophosphate Supply in Engineered Cyanobacteria for Improved Production of Natural Pigments and Terpenoid Precursors. [PDF]

Int J Mol Sci
Kanwal S, Ariyawansa HA, Karnchanatat A, Monshupanee T, Srimongkol P.   +4 more
europepmc   +1 more source

A Bio‐Based Chiroptical Overcrowded Alkene From Flavanone: Photoreactivity and Theoretical Investigation

Chemistry – A European Journal, Volume 32, Issue 34, 11 September 2026.
A sustainable route to photoresponsive molecular systems is achieved using the bio‐based flavanone (‐)‐isolonchocarpin from Tephrosia vogelii. Through McMurry homocoupling and light‐driven 6‐π‐electrocyclization, an overcrowded alkene and a fluorescent O‐heterocyclic phenanthrene are synthesized.
Deryl H. Limawan, Adrien Combe, Anthony Bongso, Bayu Dwiputra, Atthar L. Ivansyah, Roza R. Weber, Charlotte N. Stindt, Robby Roswanda, Ben L. Feringa   +8 more
wiley   +1 more source

Computational Design and Theoretical Evaluation of Novel Heterocyclic Energetic Materials Based on 5‐H‐Imidazo‐[4,5‐c]‐Pyridazine and 1,2,4‐Triazolo‐[4,3‐a]‐Pyrazine Scaffolds

Journal of Computational Chemistry, Volume 47, Issue 23, September 5, 2026.
Eighty‐eight novel energetic compounds based on 5‐H‐imidazo‐[4,5‐c]pyridazine and 1,2,4‐triazolo‐[4,3‐a]pyrazine scaffolds, functionalized with nitro, nitramino, azido, and nitrate ester groups, were theoretically evaluated by DFT. Nine candidates surpassed RDX in density and detonation performance while maintaining acceptable impact sensitivity.
Luciana Amorim da Silva, Nathália Magalhães Paixão Rosa, Danillo Fernando Vianna Cantini, Aline Cardoso Anastácio   +3 more
wiley   +1 more source

Corticospinal tract structure and descending motor output following anterior cruciate ligament reconstruction: an exploratory multimodal neuroimaging assessment. [PDF]

Front Hum Neurosci
Kim H, Geschwender C, Lepley AS.
europepmc   +1 more source

The Methylerythritol Phosphate Pathway: Promising Drug Targets in the Fight against Tuberculosis. [PDF]

ACS Infect Dis, 2018
Wang X, Dowd CS.
europepmc   +1 more source

Expression of MEP Pathway Genes and Non-volatile Sequestration Are Associated with Circadian Rhythm of Dominant Terpenoids Emission in Osmanthus fragrans Lour. Flowers. [PDF]

Front Plant Sci, 2017
Zheng R, Liu C, Wang Y, Luo J, Zeng X, Ding H, Xiao W, Gan J, Wang C.   +8 more
europepmc   +1 more source