Results 121 to 130 of about 19,660 (219)

The Effect of Renal Replacement Therapy in a Patient with Mercaptopurine Toxicity:Time to Revise Guidelines

Introduction Mercaptopurine, a thiopurine, is used in various disorders of immune regulation, such as autoimmune hepatitis. Thiopurine metabolism is complex with risk for overdosing, especially when metabolism is impaired by liver dysfunction ...
Sikma, M. A., Annema, P. A., Quaedvlieg, H. J. L., Jonge, De H. J. M., Polderman, F. N., Borkent, M., Derijks, L. J. J., Bethlehem, C.   +7 more
core   +1 more source

Differential toxic effects of azathioprine, 6-mercaptopurine and 6-thioguanine on human hepatocytes.

, 2008
International audienceThiopurines (azathioprine, 6-mercaptopurine and 6-thioguanine) are therapeutic compounds widely administered in the clinic for their multiple uses (autoimmune diseases, post-transplant immunosuppression and cancer).
Morel, Fabrice, Akhdar, Hanane, Petit, Elise, Langouët, Sophie, Nicolas-Nicolaz, Christophe, Guillouzo, André   +5 more
core   +1 more source

Genetic Polymorphism of Thiopurine S-Methyltransferase in Children with Acute Lymphoblastic Leukemia

Pakistan Journal of Medicine and Dentistry
Background: 6-Mercaptopurine (6-MP), a widely used anti-metabolite for the maintenance phase of childhood acute lymphoblastic leukemia (ALL), has been observed to cause myelotoxicity due to genetic polymorphism of thiopurine methyl transferase (TPMT ...
Afrina Raza, Shamil Ashraf, Soofia Nigar, Itimad Abdelsalam Mohamed Ayed   +3 more
doaj   +1 more source

Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: a randomised trial.

, 2006
BACKGROUND: 6-mercaptopurine has been a standard component of long-term continuing treatment for childhood lymphoblastic leukaemia, whereas 6-thioguanine has been mainly used for intensification courses.
Vora, A, Eden, OB, Richards, SM, Kinsey, S.E, Mitchell, CD, Kinsey, SE, Lennard, L, Lilleyman, J, Eden, TO, Richards, S.M., Mitchell, CL   +10 more
core   +1 more source

Immunomodulatory therapy in paediatric inflammatory bowel disease

Zdravniški Vestnik, 2013
Immunomodulatory drugs are indispensable in the treatment of children with both Crohn’s disease and ulcerative colitis, especially in maintaining remission.
András Arató
doaj  

Liver Injury From Medications Used for Treating Inflammatory Bowel Disease: The Drug-Induced Liver Injury Network Experience. [PDF]

Liver Int
Gopalakrishna H, Gu J, Li YJ, Barnhart H, Halegoua-DeMarzio D, Bonkovsky HL, Barritt AS, Molleston JP, Chalasani NP, Ghabril M.   +9 more
europepmc   +1 more source

PACSIN2 regulates mercaptopurine cytotoxicity and cellular biomechanics through Rac1 modulation in intestinal epithelial cells. [PDF]

Front Pharmacol
Norbedo A, Zudeh G, Fiducioso D, Senigagliesi B, Parisse P, Casalis L, Decorti G, Lucafò M, Stocco G.   +8 more
europepmc   +1 more source

Guselkumab as a Treatment Adjunct for Pyoderma Gangrenosum While Maintaining Clinical Remission of Ulcerative Colitis. [PDF]

ACG Case Rep J
Moghe R, Mathew AJ, Choi D, Rubin DT.
europepmc   +1 more source

Severe Thiopurine-Induced Myelosuppression in a Pediatric Acute Lymphoblastic Leukemia Patient With the NUDT15 *1/*6 Genotype: A Brief Report. [PDF]

Clin Transl Sci
Fry J, Boone EC, Wang WY, John S, Lansdon LA, Farooqi MS, Yoo B, Gaedigk A, August K, Flatt TG, Ramsey LB.   +10 more
europepmc   +1 more source

Eudragit S100-coated microbeads of thiolated chitosan/casein for pH-responsive colon-targeted delivery of 6-mercaptopurine. [PDF]

RSC Adv
Hameed H, Ahmad SM, Ghumman SA, Irfan A, Sarwar HS, Bin Jardan YA.   +5 more
europepmc   +1 more source