Results 111 to 120 of about 19,660 (219)

The Proctitis Paradox: Refractory Ulcerative Proctitis Associated With Development of Disease Complications in a Multicenter South Australian Cohort

JGH Open, Volume 10, Issue 9, September 2026.
ABSTRACT Background Despite limited extent, patients with ulcerative proctitis (UP) can suffer from debilitating symptoms, complications, and risk of disease extension. The aim was to provide a contemporary real‐world insight into the management and outcomes of UP.
Sreecanth S. Raja, Samuel P. Costello, Alexandra Sadler, Nicholas Wan, Bhuwan Tandon, Dharshan Sathananthan, Kate D. Lynch, Chris K. Rayner, Suzanne Edwards, Robert V. Bryant   +9 more
wiley   +1 more source

Chemoprevention of electrophilic damage by mercaptopurine analogs

, 1993
Analogs of 6-mercaptopurine have been found to enhance the detoxification of various electrophilic toxicants in vivo, while having minimal cytotoxicity themselves.
MacLeod, Michael C.
core   +1 more source

A Case of Cutaneous B Lymphoblastic Lymphoma With Multiple Cutaneous Tumors

JEADV Clinical Practice, Volume 5, Issue 3, Page 963-966, September 2026.
ABSTRACT A 17‐year‐old Japanese male patient was referred to our hospital due to an erythematous tumor on part of the right mandible that had developed 3 months earlier, and similar tumors had appeared on the trunk and lower extremities. A complete blood count showed no specific abnormalities.
Tomomichi Shimizu, Akio Kondoh, Fumikazu Yamazaki, Osamu Yamamoto, Tomotaka Mabuchi   +4 more
wiley   +1 more source

Phytocorrection of Gastrointestinal Tract Structural Changes Caused by the Use of 6-Mercaptopurine

Антибиотики и Химиотерапия, 2020
It was shown that the course use of Ventrofit, a complex plant remedy, normalized the structural and functional integrity of the stomach and thin intestine mucous membranes damaged by the use of 6-mercaptopurine.
YA. G. Razuvaeva, S. M. Nikolaev, A. O. Zandanov, YU. N. Sandanova, L. B. Buraeva   +4 more
doaj  

Incidence of Hepatitis B Virus Reactivation in Patients Treated With Immunosuppressive and Chemotherapeutic Agents

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 5, Page 625-634, September 2026.
HBV reactivation incidence varied across immunosuppressive and chemotherapeutic agents. Clinically meaningful HBV reactivation was also observed in patients receiving corticosteroids and conventional immunosuppressive therapies. ABSTRACT Background Data on the incidence of hepatitis B virus reactivation (HBVr) remain limited. In Japan, patients who are
Kazuhiko Ikeuchi, Makoto Saito, Kazuya Okushin, Toshiyuki Kishida, Akira Kado, Kyoji Moriya, Kazuhiko Koike, Takeya Tsutsumi, Hiroshi Yotsuyanagi   +8 more
wiley   +1 more source

Effect of Smart Pill Box on Improving Adherence to 6-Mercaptopurine Maintenance Therapy in Pediatric ALL

Indian Journal of Medical and Paediatric Oncology
Introduction 6-Mercaptopurine (6-MP) forms the backbone of maintenance chemotherapy for acute lymphoblastic leukemia (ALL). A Children's Oncology Group study found 3.9-fold increased risk of relapse in children with 6-MP adherence less than 90%
S. Abhilasha, Apoorva Bagalkotkar
doaj   +1 more source

Review Article: The Impact of the Gut Microbiome on Ulcerative Colitis Pharmacotherapy

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 6, Page 729-747, September 2026.
The gut microbiome modulates ulcerative colitis pharmacotherapy through microbial drug metabolism, immune regulation and altered drug bioavailability. Microbial composition influences response to aminosalicylates, corticosteroids, immunomodulators, biologics and small molecules, while microbiome‐targeted therapies show emerging promise.
Kate Collins, Srinivas Kamath, Rachel H. Davis, Samuel P. Costello, Robert V. Bryant, Alice S. Day, Paul Joyce   +6 more
wiley   +1 more source

Impact of 6-mercaptopurine and 6-mercaptopurine riboside on pro-inflammatory cytokines and oxidative stress in blood plasma of rats with complete Freund’s adjuvant (CFA) arthritis

Life Sciences, Medicine and Biomedicine
Inflammatory arthritis is a chronic autoimmune disorder characterized by joint inflammation and pain, often requiring effective immunosuppressive treatment. In a rat model of inflammatory arthritis, the anti-immunosuppressive effects of 6-mercaptopurine
Che Ku Dahlan-Daud, Zetty Nadia Zain, Chau Ling Tham, Yoke Keong Yong , Muhammad Nazrul Hakim   +4 more
doaj   +1 more source

Impact of Zinc‐Dependent Enzymes on Zinc Deficiency and Inflammatory Response in Ulcerative Colitis

Journal of Gastroenterology and Hepatology, Volume 41, Issue 9, Page 2751-2760, September 2026.
ABSTRACT Background and Aim Zinc (Zn) deficiency occurs in 40% of patients with ulcerative colitis (UC). Although Zn‐dependent enzymes are involved in intestinal immune regulation, their relationships with Zn deficiency and mucosal inflammation remain unclear.
Yuki Murakami, Taiho Kambe, Yu Kobayashi, Aki Sakatani, Katsuyoshi Ando, Nobuhiro Ueno, Kentaro Moriichi, Mikihiro Fujiya   +7 more
wiley   +1 more source

The pharmacokinetic effect of discontinuation of mesalazine on mercaptopurine metabolite levels in inflammatory bowel disease patients

, 2005
BACKGROUND: In vitro studies suggest interactions between mesalazine (mesalamine) and thiopurines by thiopurine S-methyltransferase (TPMT) inhibition, influencing the balance of hepatotoxic 6-methylmercaptopurine ribonucleotide and immunosuppressive ...
Engels, L.G.B., Derijks, L.J., Hooymans, P.M., Bos, L.P., Gilissen, L.P., van Gennip, A., Stockbrugger, R.W., Bierau, J.   +7 more
core   +1 more source