Results 101 to 110 of about 20,809 (211)

Allopurinol reverses mercaptopurine-induced hypoglycemia in patients with acute lymphoblastic leukemia [version 1; referees: 2 approved]

F1000Research, 2019
Fasting hypoglycemia is a known complication of mercaptopurine (6MP) maintenance therapy for acute lymphoblastic leukemia (ALL). It is associated with high levels of the methylated metabolite 6-methyl-mercaptopurine (6MMP).
Melissa Zhang, Bruce Bostrom
doaj   +1 more source

The Effect of Renal Replacement Therapy in a Patient with Mercaptopurine Toxicity:Time to Revise Guidelines

Introduction Mercaptopurine, a thiopurine, is used in various disorders of immune regulation, such as autoimmune hepatitis. Thiopurine metabolism is complex with risk for overdosing, especially when metabolism is impaired by liver dysfunction ...
Sikma, M. A., Annema, P. A., Quaedvlieg, H. J. L., Jonge, De H. J. M., Polderman, F. N., Borkent, M., Derijks, L. J. J., Bethlehem, C., Polderman, F.N., Derijks, L.J.J., Borkent, M.A., Annema, P.A., Sikma, M.A., Quaedvlieg, H.J.L., Jonge, H.J.M.   +14 more
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Potentiometric and volumetric determination of 6-mercaptopurine

, 1990
Three methods for the determination of 6-mercaptopurine in the pure state and in tablets are described. One method is based on the reaction of this compound with silver ions, whereby an equivalent amount of nitric acid is liberated, the latter being ...
Nikolić, Kosta, Velašević, Ksenija
core   +1 more source

Effects of allopurinol on 6-mercaptopurine metabolism in unselected patients with pediatric acute lymphoblastic leukemia: a prospective phase II study

Haematologica
Allopurinol can be used in maintenance therapy (MT) for pediatric acute lymphoblastic leukemia (ALL) to mitigate hepatic toxicity in patients with skewed 6- mercaptopurine metabolism.
Jonatan Källström, Riita Niinimäki, Johan Fredlund, Hartmut Vogt, Laura Korhonen, Anders Castor, Josefine Palle, Arja Harila, Magnus Borssén, Jonas Abrahamsson, Torben Ek   +10 more
doaj   +1 more source

Letter: flu-like illness with mercaptopurine and azathioprine in inflammatory bowel disease

, 2014
Letter: flu-like illness with mercaptopurine and azathioprine in inflammatory bowel ...
D Dowling (9860672), Neel Heerasing (13087041)   +1 more
core  

Chemoprevention of electrophilic damage by mercaptopurine analogs

, 1993
Analogs of 6-mercaptopurine have been found to enhance the detoxification of various electrophilic toxicants in vivo, while having minimal cytotoxicity themselves.
MacLeod, Michael C.
core   +1 more source

Nature and position of functional group on thiopurine substrates influence activity of xanthine oxidase — Enzymatic reaction pathways of 6-mercaptopurine and 2-mercaptopurine are different

, 2007
Xanthine oxidase-catalyzed hydroxylation reactions of the anticancer drug 6-mercaptopurine (6-MP) and its analog 2-mercaptopurine (2-MP) as well as 6-thioxanthine (6-TX) and 2-thioxanthine (2-TX) have been studied using UV-spectroscopy, high pressure ...
Thilagavathi, Ramasamy, Tamta, Hemlata, Kalra, Sukirti, Chakraborti, Asit K., Mukhopadhyay, Anup K.   +4 more
core   +1 more source

Genetic polymorphism of inosine-triphosphate-pyrophosphatase influences mercaptopurine metabolism and toxicity during treatment of acute lymphoblastic leukemia individualized for thiopurine-S-methyl-transferase status

, 2009
IMPORTANCE OF THE FIELD: Although genetic polymorphisms in the gene encoding human thiopurine methyltransferase (TPMT) are known to have a marked effect on mercaptopurine metabolism and toxicity, there are many patients with wild-type TPMT who develop ...
Kristine R. Crews, William E. Evans, STOCCO, GABRIELE, Kristine R Crews, Gabriele Stocco, William E Evans   +5 more
core   +1 more source

Phytocorrection of Gastrointestinal Tract Structural Changes Caused by the Use of 6-Mercaptopurine

Антибиотики и Химиотерапия, 2020
It was shown that the course use of Ventrofit, a complex plant remedy, normalized the structural and functional integrity of the stomach and thin intestine mucous membranes damaged by the use of 6-mercaptopurine.
YA. G. Razuvaeva, S. M. Nikolaev, A. O. Zandanov, YU. N. Sandanova, L. B. Buraeva   +4 more
doaj  

Effect of Smart Pill Box on Improving Adherence to 6-Mercaptopurine Maintenance Therapy in Pediatric ALL

Indian Journal of Medical and Paediatric Oncology
Introduction 6-Mercaptopurine (6-MP) forms the backbone of maintenance chemotherapy for acute lymphoblastic leukemia (ALL). A Children's Oncology Group study found 3.9-fold increased risk of relapse in children with 6-MP adherence less than 90%
S. Abhilasha, Apoorva Bagalkotkar
doaj   +1 more source