Results 101 to 110 of about 19,660 (219)

Enzyme@Silicone: A Versatile Combo for Robust Synthetic Biocatalysis?

Advanced Synthesis &Catalysis, Volume 368, Issue 17, 1 September 2026.
Silicone‐based polymers are versatile materials for enzyme immobilization, offering unique advantages such as chemical inertness, thermal stability, and tunable morphology. This review highlights their applications in synthetic biocatalysis, from batch to continuous processes, and addresses key challenges such as mass transport limitations and ...
Marion B. Ansorge‐Schumacher
wiley   +1 more source

Synthesis and anticancer activity evaluation of Novel 6 mercaptopurine derivatives. [PDF]

, 2015
A series of five (6- mercaptopurine derivatives) have been synthesized as disulfide, Schiff base, Oxadiazole and amide products and the activity as anticancer was evaluated against three types of cancer lines. The pilot studies indicated that compound 1,
Saour, Kawkab Y., Hussein, Shalal M., Jassim, Ahmed D   +2 more
core   +1 more source

Single‐Incision Laparoscopy‐First Strategy in Crohn's Disease: Risk Factors for Conversion and Surgical Outcomes

Annals of Gastroenterological Surgery, Volume 10, Issue 5, Page 1602-1611, September 2026.
In this retrospective study of 289 patients with Crohn's disease undergoing a single‐incision laparoscopy‐first (SILS‐first) strategy, conversion to open surgery was required in only 11.8% of cases. Fistula formation, colon resection, and smoking history were identified as independent risk factors for conversion, while postoperative complications and ...
Yuki Horio, Motoi Uchino, Yusuke Tomoo, Kentaro Nagano, Kurando Kusunoki, Ryuichi Kuwahara, Kei Kimura, Kozo Kataoka, Masataka Ikeda, Hiroki Ikeuchi   +9 more
wiley   +1 more source

Loading cisplatin onto 6-mercaptopurine covalently modified MSNS: a nanomedicine strategy to improve the outcome of cisplatin therapy

, 2016
Xiaojie Lv,1 Ming Zhao,1,2 Yuiji Wang,1 Xi Hu,1 Jianhui Wu,1 Xueyun Jiang,1 Shan Li,1 Chunying Cui,1 Shiqi Peng1 1Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Endogenous Prophylactic of Ministry of ...
Wu J, Zhao M, Li S, Lv X, Hu X, Jiang X, Peng S, Wang Y, Cui C   +8 more
core  

RESISTANCE TO 6-MERCAPTOPURINE: III. DELETION OF A 5′-NUCLEOTIDASE IN A 6-MERCAPTOPURINE-RESISTANT SUBLINE OF THE EHRLICH ASCITES CARCINOMA

, 1963
Nuclei prepared from cells of a 6-mercaptopurine-resistant subline of the Ehrlich ascites carcinoma differed from nuclei isolated from the parent line of cells in being markedly deficient in an enzymatic activity, 5′-nucleotidase.The nucleotidase ...
A. Hori, A. R. P. Paterson
core   +1 more source

Diagnostic BMI and Induction Therapy Weight Change Associated With Hepatotoxicity in Pediatric Patients With Acute Lymphoblastic Leukemia

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Background Hepatotoxicity is a common treatment‐related complication in pediatric acute lymphoblastic leukemia (ALL). Excess adiposity at diagnosis has been identified as a risk factor, but the impact of weight change during therapy has not been examined.
Emily J. Mason, John P. Woodhouse, Jeremy M. Schraw, Joanna S. Yi, Karen R. Rabin, M. Monica Gramatges, Mark C. Zobeck, Baojiang Chen, Melissa B. Harrell, Olga A. Taylor, Michael E. Scheurer, Philip J. Lupo, Van Huynh, Steven D. Mittelman, Etan Orgel, Austin Brown   +15 more
wiley   +1 more source

Effects of allopurinol on 6-mercaptopurine metabolism in unselected patients with pediatric acute lymphoblastic leukemia: a prospective phase II study

Haematologica
Allopurinol can be used in maintenance therapy (MT) for pediatric acute lymphoblastic leukemia (ALL) to mitigate hepatic toxicity in patients with skewed 6- mercaptopurine metabolism.
Jonatan Källström, Riita Niinimäki, Johan Fredlund, Hartmut Vogt, Laura Korhonen, Anders Castor, Josefine Palle, Arja Harila, Magnus Borssén, Jonas Abrahamsson, Torben Ek   +10 more
doaj   +1 more source

Prolonged Headache in a 13‐Year‐Old Girl With Acute Lymphoblastic Leukemia: A Case of Possible Neuroinflammatory Complication Responsive to Intravenous Immunoglobulin

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Neurological complications in pediatric acute lymphoblastic leukemia (ALL) may result from disease, CNS involvement, or treatment. We report a 13‐year‐old girl with persistent headache and blurred vision suggestive of raised intracranial pressure.
Amereh Hadizadeh, Hossein Esfahani, Firozeh Hosseini, Afshin Fayyazi, Nasibeh Ghalandari   +4 more
wiley   +1 more source

Genetic Polymorphism of Inosine Triphosphate Pyrophosphatase Is a Determinant of Mercaptopurine Metabolism and Toxicity During Treatment for Acute Lymphoblastic Leukemia

, 2009
The influence of genetic polymorphism in inosine triphosphate pyrophosphatase (ITPA) on thiopurine-induced adverse events has not been investigated in the context of combination chemotherapy for acute lymphoblastic leukemia (ALL). This study investigated
MH Cheok, WE Evans, T. Dervieux, W. Yang, D. French, C. H. Pui, STOCCO, GABRIELE, C. Cheng, KR Crews, MV Relling, D. Pei   +10 more
core   +1 more source

Efficacy of Interleukin‐12/23 and Interleukin‐23 Inhibitors for Moderately to Severely Active Crohn's Disease in Advanced Treatment Failure Populations: Systematic Review and Network Meta‐Analysis

JCC Plus, Volume 1, Issue 5, September 2026.
ABSTRACT Background and Aims Earlier trials of advanced treatments indicated for moderately to severely active Crohn's disease used predominantly re‐randomized induction responder designs, whereas newer treatments were evaluated using treat‐through designs.
Christopher Ma, Marla Dubinsky, Gil Y. Melmed, Namita Joshi, Jenny Griffith, Fernando Aponte, Brooke Kim, Eric B. Collins, Kristen Westerhoff, Remo Panaccione   +9 more
wiley   +1 more source