Results 91 to 100 of about 28,260 (215)

Clinical pharmacists’ knowledge, attitude, perception, and beliefs about the role of pharmacogenetic testing for genes polymorphisms when prescribing mercaptopurine

Saudi Pharmaceutical Journal
Background: Single nucleotide polymorphisms in the gene encoding proteins involved in mercaptopurine metabolism can influence drug efficacy and safety. This study aims to assess clinical pharmacists’ knowledge about mercaptopurine-related genes and their
Norah O. Abanmy, Sara A. Alghamdi, Raneem K. Aljudaie, Omar A. Almohammed   +3 more
doaj   +1 more source

Advancing IBD Management: A Literature Review on the Role of Non‐Invasive Blood‐Based Biomarkers in Predicting and Assessing Pharmacodynamic Response to Treatment

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Reliable biomarkers that enable noninvasive, longitudinal assessment of disease activity and therapeutic response remain a major unmet need in inflammatory bowel disease (IBD). While colonic biopsies are the gold standard for evaluating mucosal inflammation, their invasive nature and limited spatial and temporal resolution constrain their ...
Mohamed Hassanein, Li Xi, Rathi D. Ryan, Zhan (Harold) Ye, Nessy Tania, Yamato Sano, Joshua Varghese, Diogo Branquinho, Anna Sapone   +8 more
wiley   +1 more source

Allopurinol reverses mercaptopurine-induced hypoglycemia in patients with acute lymphoblastic leukemia [version 1; referees: 2 approved]

F1000Research, 2019
Fasting hypoglycemia is a known complication of mercaptopurine (6MP) maintenance therapy for acute lymphoblastic leukemia (ALL). It is associated with high levels of the methylated metabolite 6-methyl-mercaptopurine (6MMP).
Melissa Zhang, Bruce Bostrom
doaj   +1 more source

Acute Eruption in a Child With Acute Lymphoblastic Leukemia

Pediatric Dermatology, EarlyView.
L. Parra‐Navarro, N. Planella‐Fontanillas, C. Prat   +2 more
wiley   +1 more source

Effects of allopurinol on 6-mercaptopurine metabolism in unselected patients with pediatric acute lymphoblastic leukemia: a prospective phase II study

Haematologica
Allopurinol can be used in maintenance therapy (MT) for pediatric acute lymphoblastic leukemia (ALL) to mitigate hepatic toxicity in patients with skewed 6- mercaptopurine metabolism.
Jonatan Källström, Riita Niinimäki, Johan Fredlund, Hartmut Vogt, Laura Korhonen, Anders Castor, Josefine Palle, Arja Harila, Magnus Borssén, Jonas Abrahamsson, Torben Ek   +10 more
doaj   +1 more source

Phytocorrection of Gastrointestinal Tract Structural Changes Caused by the Use of 6-Mercaptopurine

Антибиотики и Химиотерапия, 2020
It was shown that the course use of Ventrofit, a complex plant remedy, normalized the structural and functional integrity of the stomach and thin intestine mucous membranes damaged by the use of 6-mercaptopurine.
YA. G. Razuvaeva, S. M. Nikolaev, A. O. Zandanov, YU. N. Sandanova, L. B. Buraeva   +4 more
doaj  

A randomised phase I study of etrolizumab (rhuMAb β7) in moderate to severe ulcerative colitis. [PDF]

, 2013
ObjectiveEtrolizumab (rhuMAb β7, anti-β7, PRO145223) is a humanised monoclonal antibody targeting the β7 subunit of the heterodimeric integrins α4β7 and αEβ7, which are implicated in leucocyte migration and retention in ulcerative colitis (UC).
Baumgart, Daniel C, Bressler, Brian, Danilenko, Dimitri, Egen, Jackson, Fedorak, Richard N, Hommes, Daan W, Keir, Mary, Luca, Diana, Mansfield, John C, O'Byrne, Sharon, Rutgeerts, Paul J, Schreiber, Stefan, Sturm, Andreas, Tang, Meina, Visich, Jennifer, Wei, Xiaohui, Williams, Marna   +16 more
core  

Effect of Smart Pill Box on Improving Adherence to 6-Mercaptopurine Maintenance Therapy in Pediatric ALL

Indian Journal of Medical and Paediatric Oncology
Introduction 6-Mercaptopurine (6-MP) forms the backbone of maintenance chemotherapy for acute lymphoblastic leukemia (ALL). A Children's Oncology Group study found 3.9-fold increased risk of relapse in children with 6-MP adherence less than 90%
S. Abhilasha, Apoorva Bagalkotkar
doaj   +1 more source

Impact of 6-mercaptopurine and 6-mercaptopurine riboside on pro-inflammatory cytokines and oxidative stress in blood plasma of rats with complete Freund’s adjuvant (CFA) arthritis

Life Sciences, Medicine and Biomedicine
Inflammatory arthritis is a chronic autoimmune disorder characterized by joint inflammation and pain, often requiring effective immunosuppressive treatment. In a rat model of inflammatory arthritis, the anti-immunosuppressive effects of 6-mercaptopurine
Che Ku Dahlan-Daud, Zetty Nadia Zain, Chau Ling Tham, Yoke Keong Yong , Muhammad Nazrul Hakim   +4 more
doaj   +1 more source

The birth of clinical organ transplantation [PDF]

, 2001
Starzl, TE
core   +1 more source