Results 71 to 80 of about 19,660 (219)
, 2023 Mercaptopurine is a crucial component in the treatment of acute lymphoblastic leukemia. It is associated with toxicities that can delay treatment. Mercaptopurine is metabolized into 6-thioguanine nucleotides and 6-methylomercaptopurine nucleotides (6MMPN)
Flatt, Terrie +3 more
core +1 more source
Azathioprine in inflammatory bowel disease, a safe alternative?
Mediators of Inflammation, 1998 Azathioprine and its metabolite 6-mercaptopurine are effective in the treatment of inflammatory bowel disease. They are mostly used for reduction of the use of steroids, maintenance therapy after remission induction by cyclosporin and treatment of ...
A. A. Tanis
doaj +1 more source
Brazilian Journal of Pharmaceutical Sciences, 2014 A reverse phase HPLC method is described for the determination of 6-mercaptopurine in bulk and tablets. Chromatography was carried on a C18 column using a mixture of acetonitrile and 0.05 mol/L sodium acetate buffer (10:90 v/v) as the mobile phase at a ...
Vanita Somasekhar
doaj +1 more source
Asia-Pacific Journal of Clinical Oncology, EarlyView.We report our single‐center experience of transplant outcomes with a busulfan, fludarabine and melphalan‐based conditioning regimen for children < 18 years of age. The regimen was shown to be well tolerated and effective for heavily pretreated children with high‐risk myeloid malignancies prior to allogeneic hematopoietic stem cell transplant.
Mayank Dhamija +6 more
wiley +1 more source
, 1991 We measured 6-mercaptopurine levels in the cerebrospinal fluid and plasma of 15 children undergoing treatment for acute leukemia. Plasma and cerebrospinal fluid samples obtained by lumbar puncture were collected before, during, and after cranial ...
Servidei, Tiziana +2 more
core +1 more source
Mercaptopurine and inflammatory bowel disease: the other thiopurine
, 2017 Background: Data about use and effectiveness of mercaptopurine in inflammatory bowel disease are relatively limited. Aims: To assess the possible therapeutic indications, efficacy and safety of mercaptopurine as an alternative to azathioprine in ...
Guerra,Iván +9 more
core +1 more source
A New Electrochemical Sensor for Direct Detection of Purine Antimetabolites and DNA Degradation
Journal of Analytical Methods in Chemistry, 2019 The development of a reliable electrochemical sensor using a hybrid nanocomposite consisting of ionic liquid (1-butyl-3-methylimidazolium hexafluorophosphate) functionalized graphene oxide (GrO-IL) and gold nanoparticles (AuNPs) stabilized by chitosan ...
Liliya K. Shpigun, Elena Yu. Andryukhina
doaj +1 more source
The Impact of Common Medications on Male Fertility: An Updated Systematic Review
Andrology, EarlyView.ABSTRACT Background Compared with those of cytotoxic treatments, the potential effects of common medications on the fertility of men trying to conceive currently or planning to conceive in the future are less well described. The use of common medications may modify the gonadotropic axis, spermatogenesis, and epididymal maturation or alter male ...
Lina Jebli +7 more
wiley +1 more source
Alimentary Pharmacology &Therapeutics, EarlyView.In a retrospective population‐based cohort study using the University of Manitoba IBD Epidemiology Database, persons with IBD have an increased risk of ESRD by nearly 50%, with CD showing greater risk than UC. Bowel surgery, allopurinol use and oral steroid therapy are important predictors, emphasising the necessity of careful renal monitoring in IBD ...
Onuma Sattayalertyanyong +4 more
wiley +1 more source
Synthesis of 9-Aikyl-6-Mercaptopurine Analogues
, 1982 Department of chemotherapy Chittaranjan National Cancer Research Centre Calcntta-700 026 Manuscript received 13 November 1980, revised 18 November.
S. K. CHAKRABORTI +2 more
core +1 more source