Results 61 to 70 of about 28,260 (215)

Effect of Oral Allopurinol in Elevated Liver Enzyme Reduction in Pediatric Acute Lymphoblastic Leukemia During Maintenance Therapy

Novelty in Biomedicine
Background: Acute lymphoid leukemia (ALL) represents a prevalent form of cancer in pediatric populations. Mercaptopurine is one of the proposed treatments for these patients. This treatment may cause multiple side effects, including liver-related effects.
Parastoo Molaei Tavana, Nader Momtazmanesh, Ahmadreza Shamshiri, Zohre Jali   +3 more
doaj   +1 more source

Dietary polyphenols influence antimetabolite agents: methotrexate, 6-mercaptopurine and 5-fluorouracil in leukemia cell lines [PDF]

, 2017
Polyphenols have been previously shown to sensitize leukemia cell lines to topoisomerase inhibitors. Here, we assess the effects of five polyphenols when used alone and in combination with antimetabolites: methotrexate, 6-mercaptopurine and 5 ...
Abels, Chandra, Cidlowski, D'Arca, Day, Domenicotti, Estrela, Hung, Jacqz-Aigrain, Jia, Jordan-Mahy, Jordan-Mahy, Jordan-Mahy, Jordan-Mahy, Juillerat-Jeanneret, Krishnan, Ledwani, Lee, Lee, Li, Liang, Locasale, Lou, Manne, Mumper, Ni, Ong, Orlowski, Ramos, Rauko, Rodríguez-López, Scalbert, Schini-Kerth, Schmiegelow, Schönthal, Sharma, Singh, Sujatha, Tsao, Veit, Weng, Weng   +41 more
core   +1 more source

CRISPR‐Cas9 Genome‐Wide Screening in Paediatric Cancer: Functional Genomics for Target Discovery and the Improvement of Existing Therapies

Medicinal Research Reviews, EarlyView.
ABSTRACT CRISPR‐Cas9 genome‐wide screening has been instrumental towards identifying novel targets for drug discovery in cancer research. However, much of this research has centred specifically on adult cancers, with paediatric cancers being underserviced by current research and screening.
Steven He, Patrick Connerty, Antoine de Weck   +2 more
wiley   +1 more source

The frequency of NUDT15 rs116855232 and its impact on mercaptopurine-induced toxicity in Syrian children with acute lymphoblastic leukemia

Frontiers in Oncology
IntroductionPolymorphisms in NUDT15 may result in differences in mercaptopurine-induced toxicity. This study aimed to identify the frequency of the NUDT15 (c.415C>T; rs116855232) polymorphism and investigate the effect of this polymorphism on ...
Muhammad Muhammad, Muhammad Muhammad, Maher Saifo, Maher Saifo, Majd Aljamali, Majd Aljamali, Mousa Alali, Khaled M. Ghanem   +7 more
doaj   +1 more source

Immunosuppressive effect of 6-mercaptopurine-riboside. IV. Studies on antibody biosynthesis [PDF]

, 1971
The effect of 6.MPR on the antibody formation of rabbits challenged with bovine serum albumin has been studied in comparison with that of 6.MP. Observation revealed that the antibody formation is profoundly suppressed when the animal is treated with 6 ...
Ogata, Masana
core   +1 more source

Single‐center experience of the Crohn's disease exclusion diet in the United States: A retrospective study

Nutrition in Clinical Practice, EarlyView.
Abstract Background The Crohn's Disease Exclusion Diet (CDED) offers a dietary means of inducing and maintaining remission for patients with Crohn's disease (CD). Descriptions of efficacy have emerged primarily from Israel, Europe, and Canada. Here, we offer real‐world experience, from a tertiary care center in the United States. Methods We conducted a
Mayah Greenfield, Caroline Salozzo, Wenya Chen, Jennifer Strople, Jeffrey Brown, Joseph Runde   +5 more
wiley   +1 more source

Variants in TPMT, ITPA, ABCC4 and ABCB1 genes as predictors of 6-mercaptopurine induced toxicity in children with acute lymphoblastic leukemia [PDF]

Journal of Medical Biochemistry, 2018
Background: Acute lymphoblastic leukemia is the most common childhood malignancy. Optimal use of anti leukemic drugs has led to less toxicity and adverse reactions, and a higher survival rate. Thiopurine drugs, including 6-mercaptopurine, are mostly used
Milošević Goran, Kotur Nikola, Krstovski Nada, Lazić Jelena, Zukić Branka, Stanković Biljana, Janić Dragana, Katsila Theodora, Patrinos George P., Pavlović Sonja, Dokmanović Lidija   +10 more
doaj  

Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes [PDF]

, 2014
Aim: We investigated candidate genes associated with thiopurine metabolism and clinical response in childhood acute lymphoblastic leukemia. Materials & methods: We performed genome-wide SNP association studies of 6-thioguanine and 6-mercaptopurine ...
Batzler, A., Cartwright, C.S., Fridley, B.L., Jenkins, G., Lennard, L., Li, F., Livshits, A., Matimba, A., Scully, S., Wang, L., Weinshilboum, R.   +10 more
core   +1 more source

Imaging of Abdominal Complications in Children With Acute Lymphoblastic Leukaemia

Journal of Medical Imaging and Radiation Oncology, EarlyView.
ABSTRACT Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy and remains one of the most common causes of cancer‐related death in children and adolescents. Five‐year overall survival rates now exceed 90% with current multidrug chemotherapeutic regimens. This improvement, coupled with the toxicity of chemotherapy, has led to the
Luke R. Holmes, Rishi S. Kotecha, Derek J. Roebuck   +2 more
wiley   +1 more source

Design and development of hydrogel nanoparticles for mercaptopurine

Journal of Advanced Pharmaceutical Technology & Research, 2010
Hydrogel nanoparticles have gained attention in recent years as they demonstrate the features and characters of hydrogels and nanoparticles at the same time.
V Senthil, R Suresh Kumar, C. V. V. Nagaraju, N Jawahar, G. N. K. Ganesh, K Gowthamarajan   +5 more
doaj   +1 more source