Results 41 to 50 of about 20,809 (211)

Physiologically based pharmacokinetic modelling of methotrexate and 6-mercaptopurine in adults and children

, 2022
This project\u27s goal is to observe how the leukemia drug 6-mercaptopurine (6-MP) interacts with the ...
Hunt, Arabella
core   +2 more sources

Patient‐reported outcomes and medication errors during oral antitumour therapy in paediatrics: Results from the youngAMBORA care programme

British Journal of Clinical Pharmacology, EarlyView.
Aim Increasing use of oral antitumour therapeutics (OAT) in paediatrics is associated with numerous advantages, but also with error‐prone aspects. Based on the randomized AMBORA trial including adults treated with various OAT, we developed a tailored pharmacological/pharmaceutical care programme for children and their caregivers during OAT treatment ...
Phyllis Lensker, Lisa Cuba, Frank Dörje, Martin F. Fromm, Markus Metzler   +4 more
wiley   +1 more source

Combination of Chlorambucil and Mercaptopurine Show Effective Anti-Cancer Effects in Mice Model

International Journal of Nanomedicine, 2023
Weibing Xu,1 Yuxin Di,1 Shengjing Chu,1 Zixuan Wang,1 Haitao Long,1 Lumei Pu,1 Runtian Ma,1 Yanwei Wang2 1College of Science, Gansu Agricultural University, Lanzhou, 730000, People’s Republic of China; 2Department of Chemical and Materials Engineering ...
Xu W, Di Y, Chu S, Wang Z, Long H, Pu L, Ma R, Wang Y   +7 more
doaj  

Dispensing of actionable pharmacogenetic drugs among adults receiving cardiovascular disease medications in the Northern Netherlands: A serial cross‐sectional study

Clinical Pharmacology &Therapeutics, EarlyView.
The extent of pharmacogenetic (PGx) drug dispensing among Dutch adults receiving medications for cardiovascular disease (CVD) is unknown. Using the University of Groningen IADB.nl pharmacy database, we performed a serial cross‐sectional study (2019–2023) to estimate the annual prevalence of PGx drug dispensing and annual rates of initiation.
Zhuolin Zhang, Guiling Zhou, Jens H. J. Bos, Eelko Hak, Talitha Feenstra, Frank Klont   +5 more
wiley   +1 more source

Mercaptopurine for the treatment of ulcerative colitis - a randomised placebo-controlled trial. [PDF]

, 2023
BACKGROUND AND AIMS Scepticism about the efficacy of thiopurines for ulcerative colitis (UC) is rising.This study aimed to evaluate mercaptopurine treatment for UC. METHODS In this prospective, randomised, double-blind, placebo-controlled trial,
Jansen, Jeroen, van der Zanden, Esmerij, van Gennep, Sara, Esmerij van der Zanden, de Boer, Nanne, Marcel Dijkgraaf, Löwenberg, Mark, Geert D’Haens, Volkers, Adriaan, D'Haens, Geert, Nahid Montazeri, Sara van Gennep, Marjolijn Duijvestein, Svend Rietdijk, Duijvestein, Marjolijn, West, Rachel, van Bodegraven, Adriaan, Aart Mookhoek, Rachel West, Dijkgraaf, Marcel, Mookhoek, Aart, Montazeri, Nahid, Adriaan van Bodegraven, Clasquin, Esmé, Mark Löwenberg, Dirk van Asseldonk, Nanne de Boer, Rietdijk, Svend, Esmé Clasquin, van Asseldonk, Dirk, Jeroen Jansen, Adriaan Volkers, d'Haens, G., Bodegraven, A. van, Jansen, J., West, R., Boer, N. de, Rietdijk, S., Dijkgraaf, M., Duijvestein, M., Volkers, A., Zanden, E. van der, Asseldonk, D. van, Mookhoek, A., Gennep, S. van, Clasquin, E., Montazeri, N., Löwenberg, M.   +47 more
core   +2 more sources

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

A computational study on the mercaptopurine drug interaction with aluminum nitride nanostructures: analyzed by Marcus theory of electron-transfer

, 2023
We analyzed the mercaptopurine adsorption on AlN nanostructures consisting of zero-dimensional nanoclusters, one-dimensional nanotubes, and two-dimensional nanosheets using calculations based on density functional theory (DFT).
Ali Alsalamy (16499583), Khalid Mujasam Batoo (17317567), Mazin Hadi Kzar (17279869), Ahmed Hussien Alawadi (17279887), F. Al-dolaimy (17317564), Noor Hanoon Haroon (17317573), Sajjad Hussain (41458), Zahraa Sabah Ghnim (17317570), Hamed Soleymanabadi (17317576)   +8 more
core   +1 more source

Effect of Oral Allopurinol in Elevated Liver Enzyme Reduction in Pediatric Acute Lymphoblastic Leukemia During Maintenance Therapy

Novelty in Biomedicine
Background: Acute lymphoid leukemia (ALL) represents a prevalent form of cancer in pediatric populations. Mercaptopurine is one of the proposed treatments for these patients. This treatment may cause multiple side effects, including liver-related effects.
Parastoo Molaei Tavana, Nader Momtazmanesh, Ahmadreza Shamshiri, Zohre Jali   +3 more
doaj   +1 more source

Dual biologic therapy in inflammatory bowel disease, a retrospective cohort study of vedolizumab and anti‐tumor necrosis factor alpha therapy in children

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Despite advances in pediatric inflammatory bowel disease (PIBD) with biologics, remission rates remain at 47%–60% with loss‐of‐response rates at 60%–68%. Evidence for efficacy of dual biologic therapy (DBT) with anti‐tumor necrosis factor alpha therapy (anti‐TNF‐α)‐ vedolizumab (VDZ) for children refractory to anti‐TNF‐α therapy is ...
Jonathan E. M. O'Donnell, Carlie Bolles, Claire R. Reilly, Manal Morgan, Christopher Burgess, Fariha Balouch, Peter J. Lewindon   +6 more
wiley   +1 more source

Effects of 6-mercaptopurine in pressure overload induced right heart failure.

PLoS ONE, 2019
BackgroundSeveral antineoplastic drugs have been proposed as new compounds for pulmonary arterial hypertension treatment but many have cardiotoxic side effects.
Julie Birkmose Axelsen, Stine Andersen, Xiao-Qing Sun, Steffen Ringgaard, Janus Adler Hyldebrandt, Kondababu Kurakula, Marie-José Goumans, Frances S de Man, Jens Erik Nielsen-Kudsk, Harm-Jan Bogaard, Asger Andersen   +10 more
doaj   +1 more source