Results 31 to 40 of about 20,809 (211)

Comprehensive analysis of dose intensity of acute lymphoblastic leukemia chemotherapy

Haematologica, 2021
Chemotherapy dosages are often compromised, but most reports lack data on dosages that are actually delivered. In two consecutive acute lymphoblastic leukemia trials that differed in their asparaginase formulation, native E.
Seth E. Karol, Deqing Pei, Colton A. Smith, Yiwei Liu, Wenjian Yang, Nancy M. Kornegay, John C. Panetta, Kristine R. Crews, Cheng Cheng, Emily R. Finch, Hiroto Inaba, Monika L. Metzger, Jeffrey E. Rubnitz, Raul C. Ribeiro, Tanja A. Gruber, Jun J. Yang, William E. Evans, Sima Jeha, Ching-Hon Pui, Mary V. Relling   +19 more
doaj   +1 more source

RESISTANCE TO 6-MERCAPTOPURINE: II THE SYNTHESIS OF THIOINOSINATE IN A 6-MERCAPTOPURINE-RESISTANT SUBLINE OF THE EHRLICH ASCITES CARCINOMA

, 1962
An assay for the synthesis of thioinosinate by the nucleotide pyrophosphorylase reaction in tissue extracts has been developed and has been applied in a comparison of the Ehrlich ascites carcinoma and a 6-mercaptopurine-resistant subline.
A. R. P. Paterson
core   +1 more source

Mercaptopurine and inflammatory bowel disease: the other thiopurine [PDF]

, 2017
Background: Data about use and effectiveness of mercaptopurine in inflammatory bowel disease are relatively limited. Aims: To assess the possible therapeutic indications, efficacy and safety of mercaptopurine as an alternative to azathioprine in ...
Guerra,Iván, López-Sanromán,Antonio, Algaba,Alicia, Hernández-Tejero,María, Bonillo,Daniel, López-Durán,Sergio, Bermejo,Fernando, Aicart-Ramos,Marta, Garrido,Elena, de-Lucas,María   +9 more
core   +1 more source

A Rapid and Reliable Absorbance Assay to Identify Drug–Drug Interactions with Thiopurine Drugs

Metabolites
Background: Thiopurine methyltransferase (TPMT) plays a crucial role in the detoxification of thiopurine drugs, including the antimetabolites azathioprine and 6-mercaptopurine (6-MP) used to treat autoimmune diseases and various cancers.
Drake A. Russell, Carson Stafford, Rheem A. Totah   +2 more
doaj   +1 more source

Impact of 6-Mercaptopurine on Enteric Gliosis [PDF]

, 2023
Inflammatory diseases of the gut, such as ulcerative colitis and Crohn’s disease, are a persistent burden for many patients all over the world. Interestingly, a growing body of evidence indicates that the enteric nervous system and especially enteric ...
Kneusels, Jan Friedel
core   +1 more source

Oral vancomycin solution is superior to capsule in inducing clinical biomarker and endoscopic remission in children with atypical ulcerative colitis

British Journal of Clinical Pharmacology, EarlyView.
Aims Atypical colitis (presenting reverse gradient colitis, backwash ileitis or rectal sparing) is associated with primary sclerosing cholangitis–ulcerative colitis (PSC). Oral vancomycin has been used to manage paediatric atypical colitis with/without confirmed PSC. Different preparations had shown different efficacy.
Laura Räisänen, Fariha Balouch, Claire Reilly, Christopher Burgess, Peter Lewindon   +4 more
wiley   +1 more source

A randomised, double-blind, parallel-group trial to assess mercaptopurine versus placebo to prevent or delay recurrence of Crohn’s disease following surgical resection (TOPPIC)

Efficacy and Mechanism Evaluation, 2017
Background: Crohn’s disease (CD) is a chronic, relapsing, inflammatory bowel disease. Up to 65% of patients with CD require an operation to control the disease within 10 years. Both endoscopic and clinical recurrence is common within 2 years of operation,
Jack Satsangi, Nicholas A Kennedy, Craig Mowat, Ian Arnott, Catriona Keerie, Steff Lewis, Holly Ennis   +6 more
doaj   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Mercaptopurine treatment should be considered in azathioprine intolerant patients with inflammatory bowel disease

, 2009
BACKGROUND: Adverse drug reactions are a significant reason for therapeutic failure during thiopurine treatment of inflammatory bowel disease. Some smaller series in this patient population have shown that a switch to mercaptopurine may be successful in ...
Hindorf, U., Kvifors, Eva,, Almer, S. H., Johansson, M., Eriksson, Anders,   +4 more
core   +2 more sources

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source