Results 11 to 20 of about 19,660 (219)

Effects of 6-mercaptopurine in pressure overload induced right heart failure.

PLoS ONE, 2019
BackgroundSeveral antineoplastic drugs have been proposed as new compounds for pulmonary arterial hypertension treatment but many have cardiotoxic side effects.
Julie Birkmose Axelsen, Stine Andersen, Xiao-Qing Sun, Steffen Ringgaard, Janus Adler Hyldebrandt, Kondababu Kurakula, Marie-José Goumans, Frances S de Man, Jens Erik Nielsen-Kudsk, Harm-Jan Bogaard, Asger Andersen   +10 more
doaj   +2 more sources

Preparation and characterization of 6-mercaptopurine-coated magnetite nanoparticles as a drug delivery system

Drug Design, Development and Therapy, 2013
Dena Dorniani,1 Mohd Zobir bin Hussein,1 Aminu Umar Kura,2 Sharida Fakurazi,2 Abdul Halim Shaari,3 Zalinah Ahmad4 1Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, 2Vaccines and Immunotherapeutics Laboratory ...
Dorniani D, Hussein MZ, Kura AU, Fakurazi S, Shaari AH, Ahmad Z   +5 more
doaj   +1 more source

Design and development of hydrogel nanoparticles for mercaptopurine

Journal of Advanced Pharmaceutical Technology & Research, 2010
Hydrogel nanoparticles have gained attention in recent years as they demonstrate the features and characters of hydrogels and nanoparticles at the same time.
V Senthil, R Suresh Kumar, C. V. V. Nagaraju, N Jawahar, G. N. K. Ganesh, K Gowthamarajan   +5 more
doaj   +2 more sources

Repurposing Mercaptopurine Through Collateral Lethality to Treat Cancers with Somatic RB1–NUDT15 Loss

MedComm
Somatic retinoblastoma 1 (RB1) loss is prevalent across different cancer types and is enriched in treatment‐refractory tumors, such as castration‐resistant prostate cancer (CRPC) and small‐cell lung cancer, but cannot be considered as a direct druggable ...
Tao Zhou, Huayun Yan, Dandan Yin, Yun Deng, Huancheng Fu, Zichen Zhao, Shuang Li, Xiaoxi Lu, Yiqi Deng, Hai‐Ning Chen, Wei‐Han Zhang, Yunying Shi, Yangjuan Bai, Bei Cai, Lanlan Wang, Zhaoqian Liu, Wei Zhang, Lili Jiang, Yang Shu, Bo Liu, Yan Zhang, Heng Xu   +21 more
doaj   +2 more sources

Mercaptopurine for the treatment of ulcerative colitis - a randomised placebo-controlled trial. [PDF]

, 2023
BACKGROUND AND AIMS Scepticism about the efficacy of thiopurines for ulcerative colitis (UC) is rising.This study aimed to evaluate mercaptopurine treatment for UC. METHODS In this prospective, randomised, double-blind, placebo-controlled trial,
Jansen, Jeroen, van der Zanden, Esmerij, van Gennep, Sara, Esmerij van der Zanden, de Boer, Nanne, Marcel Dijkgraaf, Löwenberg, Mark, Geert D’Haens, Volkers, Adriaan, D'Haens, Geert, Nahid Montazeri, Sara van Gennep, Marjolijn Duijvestein, Svend Rietdijk, Duijvestein, Marjolijn, West, Rachel, van Bodegraven, Adriaan, Aart Mookhoek, Rachel West, Dijkgraaf, Marcel, Mookhoek, Aart, Montazeri, Nahid, Adriaan van Bodegraven, Clasquin, Esmé, Mark Löwenberg, Dirk van Asseldonk, Nanne de Boer, Rietdijk, Svend, Esmé Clasquin, van Asseldonk, Dirk, Jeroen Jansen, Adriaan Volkers   +31 more
core   +3 more sources

Genetic risk variants in intestinal inflammatory disorders [PDF]

, 2010
PhDThis thesis includes work on the genetics of intestinal inflammatory disorders, concentrating on coeliac disease and Crohn’s disease. It explores how common genetic variants influence risk of complex phenotypes including immunological intolerance to
Dubois, Patrick Charles Alexander
core   +4 more sources

Polyglycolic Acid Shield Prevents Repeated Delayed Bleeding After Endoscopic Stricturotomy for Anastomotic Stricture in Crohn's Disease: A Case Report. [PDF]

DEN Open
ABSTRACT Endoscopic stricturotomy (ES) is a novel approach for treating benign strictures of the lower gastrointestinal tract. However, it is performed at a limited number of facilities, and strategies for preventing complications have not yet been established. We performed ES for ileo‐sigmoid anastomosis associated with Crohn's disease (CD).
Kikuchi H, Asari T, Tatsuta T, Nagane K, Hoshi K, Igarashi S, Maeda T, Murai Y, Ota S, Sakuraba H.   +9 more
europepmc   +2 more sources

Efficacy of 6-mercaptopurine treatment after azathioprine hypersensitivity in inflammatory bowel disease [PDF]

, 2008
AIM:To investigate the efficacy of 6-mercaptopurine (6-MP) in cases of azathioprine (AZA) hypersensitivity in patients with inflammatory bowel disease. METHODS: Twenty nine previously confirmed Crohn’s disease (CD) (n = 14) and ulcerative colitis (UC)
Nagy, Ferenc, Lonovics, János, Farkas, Kaludia, Molnár, Tamás, Szepes, Zoltán, Nyári, Tibor András   +5 more
core   +1 more source

6-thioguanine treatment in inflammatory bowel disease: A critical appraisal by a European 6-TG working party [PDF]

, 2006
Recently, the suggestion to use 6-thioguanine (6-TG) as an alternative thiopurine in patients with inflammatory bowel disease (IBD) has been discarded due to reports about possible (hepato) toxicity. During meetings arranged in Vienna and Prague in 2004,
Seiderer, J., Merwe, S. W. van der, Ochsenkühn, Thomas, Almer, S., Petritsch, W, Mulder, C. J. J, Seiderer, J, Vogelsang, H., Mulder, CJJ, Teml, A, Van Bodegraven, A. A., Teml, A., Herrlinger, K. R., Schwab, M., de Boer, NKH, Knoflach, P, van der Merwe, SW, Schwab, M, Reinisch, W., Ochsenkuhn, T, Reinisch, W, Knoflach, P., Petritsch, W., De Boer, N. K.H., De Boer, N. K. H, Van Der Merwe, S. W., Almer, Sven,, Vogelsang, H, Lukas, M., Ochsenkühn, T., van Bodegraven, AA, Lukas, M, Herrlinger, KR, Mulder, C. J.J., Bodegraven, A. A. van   +34 more
core   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source