Results 11 to 20 of about 20,809 (211)

Repurposing Mercaptopurine Through Collateral Lethality to Treat Cancers with Somatic RB1–NUDT15 Loss

MedComm
Somatic retinoblastoma 1 (RB1) loss is prevalent across different cancer types and is enriched in treatment‐refractory tumors, such as castration‐resistant prostate cancer (CRPC) and small‐cell lung cancer, but cannot be considered as a direct druggable ...
Tao Zhou, Huayun Yan, Dandan Yin, Yun Deng, Huancheng Fu, Zichen Zhao, Shuang Li, Xiaoxi Lu, Yiqi Deng, Hai‐Ning Chen, Wei‐Han Zhang, Yunying Shi, Yangjuan Bai, Bei Cai, Lanlan Wang, Zhaoqian Liu, Wei Zhang, Lili Jiang, Yang Shu, Bo Liu, Yan Zhang, Heng Xu   +21 more
doaj   +2 more sources

Preparation and characterization of 6-mercaptopurine-coated magnetite nanoparticles as a drug delivery system [PDF]

Drug Design, Development and Therapy, 2013
Dena Dorniani,1 Mohd Zobir bin Hussein,1 Aminu Umar Kura,2 Sharida Fakurazi,2 Abdul Halim Shaari,3 Zalinah Ahmad4 1Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, 2Vaccines and Immunotherapeutics Laboratory ...
Dorniani D, Hussein MZ, Kura AU, Fakurazi S, Shaari AH, Ahmad Z   +5 more
doaj   +2 more sources

Design and development of hydrogel nanoparticles for mercaptopurine

Journal of Advanced Pharmaceutical Technology & Research, 2010
Hydrogel nanoparticles have gained attention in recent years as they demonstrate the features and characters of hydrogels and nanoparticles at the same time.
V Senthil, R Suresh Kumar, C. V. V. Nagaraju, N Jawahar, G. N. K. Ganesh, K Gowthamarajan   +5 more
doaj   +2 more sources

Clinical pharmacists’ knowledge, attitude, perception, and beliefs about the role of pharmacogenetic testing for genes polymorphisms when prescribing mercaptopurine

Saudi Pharmaceutical Journal
Background: Single nucleotide polymorphisms in the gene encoding proteins involved in mercaptopurine metabolism can influence drug efficacy and safety. This study aims to assess clinical pharmacists’ knowledge about mercaptopurine-related genes and their
Norah O. Abanmy, Sara A. Alghamdi, Raneem K. Aljudaie, Omar A. Almohammed   +3 more
doaj   +2 more sources

Genetic risk variants in intestinal inflammatory disorders [PDF]

, 2010
PhDThis thesis includes work on the genetics of intestinal inflammatory disorders, concentrating on coeliac disease and Crohn’s disease. It explores how common genetic variants influence risk of complex phenotypes including immunological intolerance to
Dubois, Patrick Charles Alexander
core   +3 more sources

Efficacy of 6-mercaptopurine treatment after azathioprine hypersensitivity in inflammatory bowel disease [PDF]

, 2008
AIM:To investigate the efficacy of 6-mercaptopurine (6-MP) in cases of azathioprine (AZA) hypersensitivity in patients with inflammatory bowel disease. METHODS: Twenty nine previously confirmed Crohn’s disease (CD) (n = 14) and ulcerative colitis (UC)
Nagy, Ferenc, Lonovics, János, Farkas, Kaludia, Molnár, Tamás, Szepes, Zoltán, Nyári, Tibor András   +5 more
core   +1 more source

Polyglycolic Acid Shield Prevents Repeated Delayed Bleeding After Endoscopic Stricturotomy for Anastomotic Stricture in Crohn's Disease: A Case Report. [PDF]

DEN Open
ABSTRACT Endoscopic stricturotomy (ES) is a novel approach for treating benign strictures of the lower gastrointestinal tract. However, it is performed at a limited number of facilities, and strategies for preventing complications have not yet been established. We performed ES for ileo‐sigmoid anastomosis associated with Crohn's disease (CD).
Kikuchi H, Asari T, Tatsuta T, Nagane K, Hoshi K, Igarashi S, Maeda T, Murai Y, Ota S, Sakuraba H.   +9 more
europepmc   +2 more sources

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Theoretical EPR study of 6-Mercaptopurine [PDF]

, 2017
32nd International Physics Congress of Turkish-Physical-Society (TPS) -- SEP 06-09, 2016 -- Bodrum, TURKEY6-Mercaptopurine is important antineoplastics agent and it is used for immuno suppressive and anti inflammatory.
Ercan Türkkan, Tasdemir, Halil Ugur, Turkkan, Ercan, Halil Ugur Tasdemir   +3 more
core   +1 more source

Experts opinion on the practical use of azathioprine and 6-mercaptopurine in inflammatory bowel disease [PDF]

, 2016
The relevance of azathioprine and 6-mercaptopurine therapy in inflammatory bowel disease, Crohn's disease, and ulcerative colitis, has been challenged in recent publications.
Kessler-Brondolo, Vera, Seibold, F., Rogler, Gerhard, Juillerat, P., Mottet, Christian, Froehlich, Florian, Rogler, G., Seibold, Frank, Schoepfer, A.M., Froehlich, F., Michetti, P., Cosnes, Jacques, Vavricka, S.R., Juillerat, Pascal, Michetti, Pierre, Cosnes, J., Vavricka, Stephan R, Schoepfer, Alain M, Mottet, C., Kessler-Brondolo, V., Cosnes J, Michetti P, Juillerat P, Mottet C, Rogler G, Vavricka SR, Schoepfer AM, Seibold F, Froehlich F, Kessler-Brondolo V   +29 more
core   +2 more sources