Results 21 to 30 of about 19,660 (219)

Change in hematologic indices over time in pediatric inflammatory bowel disease treated with azathioprine [PDF]

, 2010
Azathioprine leads to changes in mean corpuscular volume (MCV) and white blood cell (WBC) indices reflecting efficacy or toxicity. Understanding the interactions between bone marrow stem cells and azathioprine could highlight abnormal response patterns ...
Cordell, Samantha J., Sally A. Connolly, Dhandapani Ashok, Chris J. Taylor, Ashok, Dhandapani, Taylor, Chris J., Connolly, Sally A., Soman, Sherman, Samantha J. Cordell, Sherman Soman, Campbell, David I., David I. Campbell   +11 more
core   +1 more source

Alopecia as the first manifestation of azathioprine myelosuppression in a genetically predisposed patient

Indian Journal of Rheumatology, 2019
Azathioprine, an analog of mercaptopurine, is used for various inflammatory/autoimmune diseases in diverse fields such as rheumatology, ophthalmology, gastroenterology, and neurology.
Debashish Mishra, Shefali Khanna Sharma, Aman Sharma, Sanjay Jain, Varun Dhir   +4 more
doaj   +1 more source

NUDT15 c.415C>T Polymorphism Predicts 6-MP Induced Early Myelotoxicity in Patients with Acute Lymphoblastic Leukemia Undergoing Maintenance Therapy

Pharmacogenomics and Personalized Medicine, 2021
Aswin Anand Pai, Ajith Mohan, Esther Sathya Bama Benjamin, Raveen Stephen Stallon Illangeswaran, Infencia Xavier Raj, Nancy Beryl Janet, Arun Kumar Arunachalam, ML Kavitha, Uday Kulkarni, Anup J Devasia, NA Fouzia, Aby Abraham, Alok Srivastava, Biju ...
Pai AA, Mohan A, Benjamin ESB, Illangeswaran RSS, Xavier Raj I, Janet NB, Arunachalam AK, Kavitha ML, Kulkarni U, Devasia AJ, Fouzia NA, Abraham A, Srivastava A, George B, Mathews V, Korula A, Balasubramanian P   +16 more
doaj  

Alternative treatment regimens in autoimmune hepatitis: how justified is their choice?

Alʹmanah Kliničeskoj Mediciny, 2018
Autoimmune hepatitis is a progressive immune-mediated liver disease of unknown etiology. Its key characteristics include hyper-gammaglobulinemia, circulating autoantibodies, and periportal inflammation seen in a liver biopsy sample.
M. V. Matsievich, A. O. Bueverov, M. Yu. Petrachenkova   +2 more
doaj   +1 more source

A Comprehensive Approach to Compatibility Testing Using Chromatographic, Thermal and Spectroscopic Techniques: Evaluation of Potential for a Monolayer Fixed-Dose Combination of 6-Mercaptopurine and Folic Acid

Pharmaceuticals, 2021
In this work, a systematical compatibility investigation of 6-mercaptopurine and folic acid, two commonly used medications in the treatment of inflammatory bowel disease, for the needs of a fixed-dose combination development strategy is shown.
Edvin Brusač, Mario-Livio Jeličić, Matija Cvetnić, Daniela Amidžić Klarić, Biljana Nigović, Ana Mornar   +5 more
doaj   +1 more source

Multilocus genotypes of relevance for drug metabolizing enzymes and therapy with thiopurines in patients with acute lymphoblastic leukemia

Frontiers in Genetics, 2013
Multilocus genotypes have been shown to be of relevance for using pharmacogenomic principles to individualize drug therapy. As it relates to thiopurine therapy, genetic polymorphisms of TPMT are strongly associated with the pharmacokinetics and clinical ...
Gabriele eStocco, Gabriele eStocco, Raffaella eFranca, Federico eVerzegnassi, Margherita eLondero, Margherita eLondero, Marco eRabusin, Giuliana eDecorti   +7 more
doaj   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Experts opinion on the practical use of azathioprine and 6-mercaptopurine in inflammatory bowel disease [PDF]

, 2016
The relevance of azathioprine and 6-mercaptopurine therapy in inflammatory bowel disease, Crohn's disease, and ulcerative colitis, has been challenged in recent publications.
Kessler-Brondolo, Vera, Seibold, F., Rogler, Gerhard, Juillerat, P., Mottet, Christian, Froehlich, Florian, Rogler, G., Seibold, Frank, Schoepfer, A.M., Froehlich, F., Michetti, P., Cosnes, Jacques, Vavricka, S.R., Juillerat, Pascal, Michetti, Pierre, Cosnes, J., Vavricka, Stephan R, Schoepfer, Alain M, Mottet, C., Kessler-Brondolo, V.   +19 more
core   +2 more sources

A randomised, double-blind, parallel-group trial to assess mercaptopurine versus placebo to prevent or delay recurrence of Crohn’s disease following surgical resection (TOPPIC)

Efficacy and Mechanism Evaluation, 2017
Background: Crohn’s disease (CD) is a chronic, relapsing, inflammatory bowel disease. Up to 65% of patients with CD require an operation to control the disease within 10 years. Both endoscopic and clinical recurrence is common within 2 years of operation,
Jack Satsangi, Nicholas A Kennedy, Craig Mowat, Ian Arnott, Catriona Keerie, Steff Lewis, Holly Ennis   +6 more
doaj   +1 more source

Allele-specific polymerase chain reaction can determine the diplotype of NUDT15 variants in patients with childhood acute lymphoblastic Leukemia

Scientific Reports, 2023
Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric patients with acute lymphoblastic leukemia (ALL). NUDT15 variants have emerged as major determinants of mercaptopurine intolerance, especially in the Asian ...
Chih-Hsiang Yu, Ya-Hsuan Chang, Der-Shiun Wang, Shiann-Tarng Jou, Chien-Yu Lin, Kai-Hsin Lin, Meng-Yao Lu, Kang-Hsi Wu, Chao-Neng Cheng, Hsiu-Hao Chang, Shu-Wei Chou, Min-Yu Su, Yu-Ling Ni, Pei-Yuan Xu, Dong-Tsamn Lin, Shu-Wha Lin, Hsuan-Yu Chen, Yung-Li Yang   +17 more
doaj   +1 more source