Results 21 to 30 of about 20,809 (211)

6-thioguanine treatment in inflammatory bowel disease: A critical appraisal by a European 6-TG working party [PDF]

, 2006
Recently, the suggestion to use 6-thioguanine (6-TG) as an alternative thiopurine in patients with inflammatory bowel disease (IBD) has been discarded due to reports about possible (hepato) toxicity. During meetings arranged in Vienna and Prague in 2004,
Seiderer, J., Merwe, S. W. van der, Ochsenkühn, Thomas, Almer, S., Petritsch, W, Mulder, C. J. J, Seiderer, J, Vogelsang, H., Mulder, CJJ, Teml, A, Teml, A., Herrlinger, K. R., Schwab, M., de Boer, NKH, Knoflach, P, van der Merwe, SW, Schwab, M, Reinisch, W., Ochsenkuhn, T, Reinisch, W, Knoflach, P., Petritsch, W., De Boer, N. K. H, Almer, Sven,, Vogelsang, H, Lukas, M., van Bodegraven, AA, Lukas, M, Herrlinger, KR, Bodegraven, A. A. van   +29 more
core   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Adsorption Investigation of Boron Nitride Nanoparticle as Biodegradable Drug Delivery Carriers for the Mercaptopurine Anti-cancer Drug by Density Functional Theory [PDF]

Journal of Sciences, Islamic Republic of Iran
Cancer is one of the most common diseases that affects many people around the world, and one of the challenges of the scientific community in dealing with cancer is to deliver drugs to cancerous tumors.
Nasrin Masnabadi, Marjaneh Samadizadeh, Ladan Sardarzadeh   +2 more
doaj   +1 more source

A Comprehensive Approach to Compatibility Testing Using Chromatographic, Thermal and Spectroscopic Techniques: Evaluation of Potential for a Monolayer Fixed-Dose Combination of 6-Mercaptopurine and Folic Acid

Pharmaceuticals, 2021
In this work, a systematical compatibility investigation of 6-mercaptopurine and folic acid, two commonly used medications in the treatment of inflammatory bowel disease, for the needs of a fixed-dose combination development strategy is shown.
Edvin Brusač, Mario-Livio Jeličić, Matija Cvetnić, Daniela Amidžić Klarić, Biljana Nigović, Ana Mornar   +5 more
doaj   +1 more source

TPMT Genetic Variability and Its Association with Hematotoxicity in Indonesian Children with Acute Lymphoblastic Leukemia in Maintenance Therapy

Pharmacogenomics and Personalized Medicine, 2021
Dewi Selvina Rosdiana,1 Rianto Setiabudy,1 Rizka Andalusia,2,3 Djajadiman Gatot,4 Melva Louisa,1 Saptawati Bardosono,5 Instiaty Instiaty1 1Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia ...
Rosdiana DS, Setiabudy R, Andalusia R, Gatot D, Louisa M, Bardosono S, Instiaty I   +6 more
doaj  

Alopecia as the first manifestation of azathioprine myelosuppression in a genetically predisposed patient

Indian Journal of Rheumatology, 2019
Azathioprine, an analog of mercaptopurine, is used for various inflammatory/autoimmune diseases in diverse fields such as rheumatology, ophthalmology, gastroenterology, and neurology.
Debashish Mishra, Shefali Khanna Sharma, Aman Sharma, Sanjay Jain, Varun Dhir   +4 more
doaj   +1 more source

Allele-specific polymerase chain reaction can determine the diplotype of NUDT15 variants in patients with childhood acute lymphoblastic Leukemia

Scientific Reports, 2023
Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric patients with acute lymphoblastic leukemia (ALL). NUDT15 variants have emerged as major determinants of mercaptopurine intolerance, especially in the Asian ...
Chih-Hsiang Yu, Ya-Hsuan Chang, Der-Shiun Wang, Shiann-Tarng Jou, Chien-Yu Lin, Kai-Hsin Lin, Meng-Yao Lu, Kang-Hsi Wu, Chao-Neng Cheng, Hsiu-Hao Chang, Shu-Wei Chou, Min-Yu Su, Yu-Ling Ni, Pei-Yuan Xu, Dong-Tsamn Lin, Shu-Wha Lin, Hsuan-Yu Chen, Yung-Li Yang   +17 more
doaj   +1 more source

Alternative treatment regimens in autoimmune hepatitis: how justified is their choice?

Alʹmanah Kliničeskoj Mediciny, 2018
Autoimmune hepatitis is a progressive immune-mediated liver disease of unknown etiology. Its key characteristics include hyper-gammaglobulinemia, circulating autoantibodies, and periportal inflammation seen in a liver biopsy sample.
M. V. Matsievich, A. O. Bueverov, M. Yu. Petrachenkova   +2 more
doaj   +1 more source

The effect of 6-mercaptopurine on natural killer-cell activities in Crohn's disease [PDF]

, 1985
Crohn's disease patients on long-term 6-mercaptopurine therapy (more than 4 months) were evaluated for activity of peripheral blood natural killer cells. Natural killer-cell cytolytic activity against K-562 tumor-cell targets was examined, as was natural
R. Stevens, B. Korelitz, Stevens, R., M. Oliver, S. Targan, Targan, S., M. Brogan, Oliver, M., Hiserodt, J. C., J. Hiserodt, Korelitz, B., Brogan, M.   +11 more
core   +1 more source

Pharmacogenetic Testing for the Pediatric Gastroenterologist: Actionable Drug–Gene Pairs to Know

Pharmaceuticals, 2023
Gastroenterologists represent some of the earlier adopters of precision medicine through pharmacogenetic testing by embracing upfront genotyping for thiopurine S-methyltransferase nucleotide diphosphatase (TPMT) before prescribing 6-mercaptopurine or ...
Tracy Sandritter, Rachel Chevalier, Rebecca Abt, Valentina Shakhnovich   +3 more
doaj   +1 more source