Results 51 to 60 of about 19,660 (219)
Food Safety and Health, EarlyView.In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso +3 more
wiley +1 more source
Life Science Alliance, 2023 This study evaluates the role of PACSIN2 in autophagy modulation and its impact on mercaptopurine cytotoxicity in lymphoid and intestinal models.
Giulia Zudeh +10 more
doaj +1 more source
Altered expression of DNMT3A gene in B-cell acute lymphoblastic leukemia by mercaptopurine
فصلنامه دانشگاه علوم پزشکی جهرم, 2021 Introduction: Current medications used for acute lymphoblastic leukemia (ALL) such as mercaptopurine target molecular factors involved in its onset and progression including DNA methyltransferases (DNMTs) because these enzymes are implicated in ...
Seyedhossein Hekmatimoghaddam +4 more
doaj
Cyclophosphamide: An Alternative Treatment in Crohn’s Disease
Canadian Journal of Gastroenterology, 1989 lmmunosuppressive therapy in the form of 6-mercaptopurine has shown a 66% efficacy in severe, debilitating, highly corticosteroid dependent Crohn’s disease. Nevertheless this medication has some important side effects such as nausea, vomiting, leukopenia
Gilles Lapointe, Aubin Charbonneau
doaj +1 more source
Metabolic feature profiling and metabolic vulnerability in acute lymphoblastic leukemia
Interdisciplinary Medicine, EarlyView.For the first time, our study develops a novel metabolic classification and subtyping program, metabolic reprogramming‐based classifier for acute lymphoblastic leukemia, using internal PDT‐ALL‐2016 and external cohorts, which dissects metabolic profiling, clinical outcome, and therapeutic vulnerability for precision metabolic intervention in ALL ...
Xiaojie Liang +13 more
wiley +1 more source
مجلة جامعة دمشق للعلوم الطبية, 2021 Background and Aims: NUDT15 genetic polymorphism is known to be associated with frequent hematopoietic toxicities during acute lymphoblastic leukemia (ALL) mercaptopurine therapy.
محمد ماجد محمد
doaj
Journal of Pediatric Gastroenterology and Nutrition, EarlyView.Abstract Objectives Despite advances in pediatric inflammatory bowel disease (PIBD) with biologics, remission rates remain at 47%–60% with loss‐of‐response rates at 60%–68%. Evidence for efficacy of dual biologic therapy (DBT) with anti‐tumor necrosis factor alpha therapy (anti‐TNF‐α)‐ vedolizumab (VDZ) for children refractory to anti‐TNF‐α therapy is ...
Jonathan E. M. O'Donnell +6 more
wiley +1 more source
Potentiometric and volumetric determination of 6-mercaptopurine
, 1990 Three methods for the determination of 6-mercaptopurine in the pure state and in tablets are described. One method is based on the reaction of this compound with silver ions, whereby an equivalent amount of nitric acid is liberated, the latter being ...
Nikolić, Kosta, Velašević, Ksenija
core +1 more source
Journal of Pediatric Gastroenterology and Nutrition, EarlyView.Abstract Objectives To estimate the effect of attention deficit hyperactivity disorder (ADHD) and autism on the disease activity of inflammatory bowel disease (IBD) in pediatric and young patients. Methods Patients diagnosed with IBD between the ages of 6 and 24 years were identified in Danish nationwide registries 1996–2022.
Sabine Jansson +7 more
wiley +1 more source
, 1962 An assay for the synthesis of thioinosinate by the nucleotide pyrophosphorylase reaction in tissue extracts has been developed and has been applied in a comparison of the Ehrlich ascites carcinoma and a 6-mercaptopurine-resistant subline.
A. R. P. Paterson
core +1 more source