Results 91 to 100 of about 4,546 (178)

Circ‐0030167/IGF2BP1 Induces Mitophagy‐Mediated Ferroptosis via HMOX1 mRNA Stabilization in Pancreatic Cancer

Cancer Science, EarlyView.
Our findings identify circ‐0030167/IGF2BP1/HMOX1 axis as a critical regulatory factor targeting mitochondria‐mediated ferroptosis, thereby presenting a novel therapeutic target for PC combination therapies. ABSTRACT Pancreatic cancer (PC) represents a highly aggressive malignancy characterized by a 5 year survival rate of less than 12%.
Qun Zhao, Xihao Yao, Jingjing Lu, Qiyang Chen, Zhiwei Wang, Xiaohong Li, Yuhua Lu   +6 more
wiley   +1 more source

Antibiotic-Induced Gut Microbiota Dysbiosis Modulates Host Transcriptome and m6A Epitranscriptome via Bile Acid Metabolism. [PDF]

Gut microbiota can influence host gene expression and physiology through metabolites. Besides, the presence or absence of gut microbiome can reprogram host transcriptome and epitranscriptome as represented by N6-methyladenosine (m6A), the most abundant ...
Chang, Eugene, Cheng, Wei, Eren, A, Fan, Jiajun, Huang, Jia, Huang, Shi, Huo, Zhengyi, Jiao, Yuting, Jobin, Christian, Lai, Yushan, Lee, Gina, Liu, Biaodi, Lu, Yi, Luo, Guan-Zheng, Pan, Tao, Pang, Rui, Qi, Jiali, Wang, Xiaoyun, Wei, Hong, Xu, Zihe, Yan, Tong-Meng, Yang, Meng, Zhang, Nianping, Zheng, Xiaoqi, Zhong, Xiang   +24 more
core   +2 more sources

GPRC5B Identified by m5C meRIP‐Seq Suppresses Apoptosis in Osteosarcoma Through NSUN2‐Mediated RNA Methylation

Cancer Science, EarlyView.
We performed the first transcriptome‐wide profiling of m5C modifications in osteosarcoma, analyzing four pairs of tumor and adjacent normal tissues. We revealed that NSUN2 suppresses apoptosis in osteosarcoma cells by promoting GPRC5B m5C modification and expression.
Zhenyi Chen, Min Yang, Xiaoxiao Liang, Zhiqiang Yang, Wulan Mai, Yuyang Wang, Yushen Lu, Ruimin Wang, Yuanhang Han, Yuanlong Xie, Lin Cai   +10 more
wiley   +1 more source

StALKBH10B‐Mediated RNA m6A Modification Inhibits Potato Salt Tolerance by Targeting Flavonoids and ABA Signalling Pathways

Plant Biotechnology Journal, EarlyView.
ABSTRACT N6‐methyladenosine (m6A) is the most prevalent methylation modification present in mRNAs, which has been confirmed to participate in many developmental and biological processes. However, the biological function and specific regulatory mechanism of m6A modification in relation to salt tolerance of potato remain obscure.
Xuanming Dong, Jianyu Ma, Chenxin Sui, Yan Li, Vadim Khassanov, Hongju Jian, Dianqiu Lv   +6 more
wiley   +1 more source

IGF2BP3 promotes mRNA degradation through internal m⁷G modification [PDF]

Recent studies have suggested that mRNA internal m7G and its writer protein METTL1 are closely related to cell metabolism and cancer regulation. Here, we identify that IGF2BP family proteins IGF2BP1-3 can preferentially bind internal mRNA m7G.
Dai, Qing, Dou, Xiaoyang, He, Chuan, Liu, Chang, Liu, Jun, Wu, Tong, Xiao, Yu, Zhang, Linda, Zhang, Lisheng, Zhao, Yutao   +9 more
core   +1 more source

MOESM1 of RADAR: differential analysis of MeRIP-seq data with a random effect model

, 2019
Additional file 1: Figure S1. Scatter plot of read count. Figure S2. Read count distribution of INPUT data. Figure S3. Sequencing depth distribution of m6A-seq in published literatures. Figure S4. Variability distribution comparing RNA-seq and m6A-seq (MeRIP-seq). Figure S5. Evaluating performances of benchmarked methods on simulated data using sliding
Zhang, Zijie, Zhan, Qi, Eckert, Mark, Zhu, Allen, Chryplewicz, Agnieszka, De Jesus, Dario, Ren, Decheng, Kulkarni, Rohit, Lengyel, Ernst, He, Chuan, Chen, Mengjie   +10 more
openaire   +1 more source

Salt Stress Adaptations in Soybean Involve Alterations in Pre‐mRNA Processing

Plant, Cell &Environment, EarlyView.
ABSTRACT Salt stress can seriously affect plant survival. To adapt to salt stress, plants can alter gene expressions and/or pre‐mRNA processing patterns, or both. Previous studies could not comprehensively profile stress‐responsive pre‐mRNA processing patterns due to limitations in traditional sequencing technologies.
Shoudong Zhang, Zhixia Xiao, Ailin Liu, Dongpeng Ren, Shengjie Chen, Hanxue Zhang, Li Zhang, Zhili Wang, Jun Yang, Hon‐Ming Lam   +9 more
wiley   +1 more source

Synchronous profiling of mRNA N6-methyladenosine modifications and mRNA expression in high-grade serous ovarian cancer: a pilot study

Scientific Reports
This study aimed to synchronously determine epitranscriptome-wide RNA N6-methyladenosine (m6A) modifications and mRNA expression profile in high grade serous ovarian cancer (HGSOC).
Li Yang, Jingfang Liu, Yanlu Jin, Jie Xing, Jiejie Zhang, Xin Chen, Aijun Yu   +6 more
doaj   +1 more source

MOESM2 of RADAR: differential analysis of MeRIP-seq data with a random effect model

, 2019
Additional file 2. Review history.
Zhang, Zijie, Zhan, Qi, Eckert, Mark, Zhu, Allen, Chryplewicz, Agnieszka, De Jesus, Dario, Ren, Decheng, Kulkarni, Rohit, Lengyel, Ernst, He, Chuan, Chen, Mengjie   +10 more
openaire   +1 more source

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source