Results 11 to 20 of about 4,546 (178)

MeRIP-Seq initially revealed the role of m6A modification in Chinese sacbrood virus-infected <i>Apis cerana</i> larvae. [PDF]

Front Microbiol
Chinese sacbrood virus (CSBV) is highly lethal to honeybee larvae (especially the larva of Apis cerana) and causes considerable losses to beekeeping industry. N6-methyladenine (m6A) modification of mRNA is a predominant post-transcriptional modification in eukaryotes and plays a role in viral infection.
Liu Y, Bai H, Qiu H, Fei D, Ma M.
europepmc   +4 more sources

m6A epigenetic signature in necrotizing enterocolitis: insights from murine to neonatal studies [PDF]

Frontiers in Immunology
Necrotizing enterocolitis (NEC) is a severe intestinal infectious disease. m6A modification plays a critical role in intestinal homeostasis and infection, while its role in NEC remains unclear.
Yixian Chen, Yixian Chen, Qiaozhen Wei, Yuan Gan, Ba Wei, Qingmei Huang, Shuangjing Pan, Yujun Chen   +7 more
doaj   +2 more sources

Construction of RNA m6A profiles in liver tissue of mice in sepsis-induced liver injury based on m6A MeRIP-seq and RNA-seq. [PDF]

Eur J Med Res
Abstract Sepsis-induced liver injury (SILI) indicates liver functional or structural impairment occurring during sepsis and is one of the common complications of sepsis. N6-methyladenosine (m6A) modification plays a significant role in the pathological processes of SILI, but its specific mechanisms remain unclear and require further ...
Li L, Li P, He Y, Xu Z, Fan Y, Jia X, Liu Y, Qin L.   +7 more
europepmc   +4 more sources

Comprehensive Analysis of N6-Methyladenosine Methylation in Transverse Aortic Constriction-Induced Cardiac Fibrosis Based on MeRIP-Seq Analysis. [PDF]

Biomedicines
Background: The function and mechanism of N6-methyladenosine (m6A) methylation in pressure-overload cardiac fibrosis remains limited and unclear. This study aims to analyze and predict m6A modifications present in mouse hearts because of transverse aortic constriction (TAC).
Liu S, Zhao P, He Y, Wang J, Song B, Yu C.   +5 more
europepmc   +3 more sources

Role of N6-methyladenosine methylation in transverse aortic constriction-induced cardiac fibrosis: insights from MeRIP-seq analysis. [PDF]

Mol Biol Rep
Abstract This study aimed to investigate the role and potential mechanisms of N6-methyladenosine (m6A) methylation in a mouse model of transverse aortic constriction (TAC)-induced cardiac fibrosis using MeRIP-seq. A TAC-induced cardiac fibrosis mouse model was established, and cardiac function and structural parameters were assessed by ...
Liu S, Liu H, Bai Q, Wei Z, Zhao P, Chen H, Song B, Yu C.   +7 more
europepmc   +3 more sources

Epigenetic Effects and Potential Contributions of m⁶A Modification to Mammary Gland Development and Lactation of Dairy Goats Explored via MeRIP-seq. [PDF]

Animals (Basel)
To date, more than 170 chemical modifications have been identified in RNA. m6A (N6-methyladenine) RNA methylation is the most abundant form of mRNA modification in eukaryotes, playing an important role in RNA post-transcriptional processes. To investigate the function of m6A methylation modification in the development and lactation of dairy goat ...
Zhang L, Ji Z, Zhao M, Fu J, Meng X.
europepmc   +3 more sources

Deep learning model and omics screening highlight angiotensinogen as a 5-methylcytosine (m5C) regulated mediator of tumor-microenvironment communication in liver cancer [PDF]

Frontiers in Immunology
IntroductionThe tumor microenvironment (TME) is critical for liver cancer progression and therapy response. As a key RNA modification, 5-methylcytosine (m5C) methylation is implicated in this process, yet the molecular mechanisms by which m5C ...
Huai Pang, Huai Pang, Huai Pang, Linshu Wang, Yang Li, Yuan Zhou, Yuan Zhou   +6 more
doaj   +2 more sources

A novel algorithm for calling mRNA m6A peaks by modeling biological variances in MeRIP-seq data. [PDF]

Bioinformatics, 2016
Abstract Motivation:   N 6 -methyl-adenosine (m 6 A) is the most prevalent mRNA methylation but precise prediction of its mRNA location is important for understanding its function. A recent sequencing technology, known as Methylated RNA Immunoprecipitation Sequencing technology (MeRIP-seq), has been developed for transcriptome-wide ...
Cui X, Meng J, Zhang S, Chen Y, Huang Y.
europepmc   +4 more sources

YTHDF2 enhances proliferation and metastasis of nasopharyngeal carcinoma by mediating m6A modification in destabilizing FOXO1 mRNA [PDF]

Cancer Biology & Therapy
Background Aberrant N6-methyladenosine (m6A) modification is linked to cancer development and progression. However, the role of YTH N6-methyladenosine RNA binding protein F2 (YTHDF2), an m6A ‘reader protein’, in nasopharyngeal carcinoma (NPC) is poorly ...
Peng Yu, Wenyang Wei, Xinyun Peng, Jiemei Ye, Yuanli Ji, Bin Zhang, Yonglin Cai   +6 more
doaj   +2 more sources

KIAA1429 in non-small cell lung cancer: bridging m6A epigenetics to therapeutic innovation. [PDF]

Front Surg
As a pivotal component of the m6A methyltransferase complex, KIAA1429 plays a critical regulatory role in the pathogenesis of non-small cell lung cancer (NSCLC), driving tumorigenesis, metastasis, and therapeutic resistance through epigenetic mechanisms.
Liu H, Shi K, Liu L, You BH, Liu T, Ren XF, Guo Q, Li D.   +7 more
europepmc   +3 more sources