Results 41 to 50 of about 4,546 (178)
Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation [PDF]
, 2023 We report a novel translation-regulatory function of G9a, a histone methyltransferase and well-understood transcriptional repressor, in promoting hyperinflammation and lymphopenia; two hallmarks of endotoxin tolerance (ET)-associated chronic inflammatory
Chen, Xian +19 more
core +2 more sources
METTL3 regulates WTAP protein homeostasis [PDF]
, 2018 The Wilms tumor 1 (WT1)-associated protein (WTAP) is upregulated in many tumors, including, acute myeloid leukemia (AML), where it plays an oncogenic role by interacting with different proteins involved in RNA processing and cell proliferation.
Capuano, Ernestina +8 more
core +2 more sources
The Role of N6-methyladenosine RNA Methylation in the Regulation of Hematopoietic Stem Cells [PDF]
, 2020 Hematopoietic stem cells (HSCs) give rise to all blood cells and are characterized by their ability for life-long self-renewal and multilineage differentiation.
Lee, Heather
core +2 more sources
A protocol for RNA methylation differential analysis with MeRIP-Seq data and exomePeak R/Bioconductor package [PDF]
Methods, 2014 Despite the prevalent studies of DNA/Chromatin related epigenetics, such as, histone modifications and DNA methylation, RNA epigenetics has not drawn deserved attention until a new affinity-based sequencing approach MeRIP-Seq was developed and applied to survey the global mRNA N6-methyladenosine (m(6)A) in mammalian cells. As a marriage of ChIP-Seq and
Jia, Meng +7 more
openaire +2 more sources
Comprehensive analysis of RNA m6A methylation in pressure overload-induced cardiac hypertrophy
BMC Genomics, 2022 Aim To analyze and compare the mRNA N6-methyladenosine modifications in transverse aortic constriction induced mice hearts and normal mice hearts. Materials and methods Colorimetric quantification was used to probe the changes in m6A modifications in the
Weidong Li +6 more
doaj +1 more source
Hepatology Communications, 2023 Whether N6-methyladenosine (m6A) is involved in biliary atresia (BA) remains undefined. Herein, we comprehensively evaluated the m6A profile in BA. When compared with normal controls, BA had an elevated m6A level with upregulated m6A writers.
Junfeng Wang +10 more
doaj +1 more source
m6a RNA methylation: the implications for health and disease [PDF]
, 2014 The recent resurgence of interest in m6a has been spurred by some intriguing findings detailing the effects and dynamics of this epigenetic modification.
McGuinness, D., Mcguinness, D.H.
core +1 more source
BMC Genomics, 2022 Background Heat stress has a substantial negative economic impact on the dairy industry. N6-methyladenosine (m6A) is the most common internal RNA modification in eukaryotes and plays a key role in regulating heat stress response in animals. In dairy cows,
Ying Qi +4 more
doaj +1 more source
HIV Modifies the m6A and m5C Epitranscriptomic Landscape of the Host Cell [PDF]
, 2021 The study of RNA modifications, today known as epitranscriptomics, is of growing interest. The N6-methyladenosine (m6A) and 5-methylcytosine (m5C) RNA modifications are abundantly present on mRNA molecules, and impact RNA interactions with other proteins
Angelino, Paolo +4 more
core +1 more source
Recent advances in functional annotation and prediction of the epitranscriptome [PDF]
, 2021 RNA modifications, in particular N(6)-methyladenosine (m(6)A), participate in every stages of RNA metabolism and play diverse roles in essential biological processes and disease pathogenesis.
Fan, Xiao-Nan +4 more
core +1 more source