Results 51 to 60 of about 4,546 (178)

FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner

Journal of Experimental & Clinical Cancer Research, 2022
Background N6-methyladenosine (m6A) modification is the most common chemical modification in mammalian mRNAs, and it plays important roles by regulating several cellular processes.
Jiapeng Huang, Wei Sun, Zhihong Wang, Chengzhou Lv, Ting Zhang, Dalin Zhang, Wenwu Dong, Liang Shao, Liang He, Xiaoyu Ji, Ping Zhang, Hao Zhang   +11 more
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m6A Methylation Analysis of Differentially Expressed Genes in Skin Tissues of Coarse and Fine Type Liaoning Cashmere Goats

Frontiers in Genetics, 2020
N6-methyladenosine (m6A) is the most common internal modification in mRNAs of all higher eukaryotes. Here we perform two high-throughput sequencing methods, m6A-modified RNA immunoprecipitation sequence (MeRIP-seq) and RNA sequence (RNA-seq) to identify ...
Yanru Wang, Yuanyuan Zheng, Dan Guo, Xinghui Zhang, Suling Guo, Taiyu Hui, Chang Yue, Jiaming Sun, Suping Guo, Zhixian Bai, Weidong Cai, Xinjiang Zhang, Yixing Fan, Zeying Wang, Wenlin Bai   +14 more
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Mettl3 deficiency leads to the upregulation of Cav1.2 and increases arrhythmia susceptibility in mice

Acta Biochimica et Biophysica Sinica, 2022
Methyltransferase-like 3 (Mettl3) is a component of methyltransferase complex that mediates m6A modification of RNAs, and participates in multiple biological processes. However, the role of Mettl3 in cardiac electrophysiology remains unknown.
Shi Ling, Jin Xuexin, Li Zheng, Gong Rui, Guo Yang, Ma Jiudong, Zhang Yang, Cai Benzhi, Yang Baofeng, Gong Dongmei, Pan Zhenwei   +10 more
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Characterization of Enterovirus Associated m6A RNA Methylation in Children With Neurological Symptoms: A Prospective Cohort Study

Frontiers in Neuroscience, 2021
Little is known about the particular changes of N6-methyladenosine (m6A) RNA methylation in enterovirus (EV) infection among children with neurologic symptoms.
Danping Zhu, Yongling Song, Dandan Hu, Suyun Li, Guangming Liu, Peiqing Li, Sida Yang   +6 more
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MeRIP-seq and RNA-seq data of mycelium and spore ofAscosphaera apis, a widespread bee fungal pathogen [PDF]

, 2020
ABSTRACTAscosphaera apisis widespread fungal pathogen of honeybee larvae, causing chalkbrood, a chronic disease that weakens bee health and colony productivity. In this article, mecylia and spores ofA. apiswere respectively purified followed by RNA isolation, cDNA library construction, MeRIP-seq and RNA-seq.
Du, Yu, Jiang, Haibin, Zhu, Zhiwei, Wang, Jie, Chen, Huazhi, Xiong, Cuiling, Zheng, Yanzhen, Chen, Dafu, Guo, Rui   +8 more
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RNA 메틸화 변형에 의한 인간 L1 레트로트랜스포존의 진화 기작 연구 [PDF]

, 2021
학위논문(박사) -- 서울대학교대학원 : 자연과학대학 생명과학부, 2021.8. 황성연.Long interspersed element-1 (LINE-1; L1) comprises a group of active autonomous retrotransposons in humans.
황성연
core  

MeRIP-PF: An Easy-to-Use Pipeline for High-Resolution Peak-Finding in MeRIP-Seq Data

Genomics, Proteomics & Bioinformatics, 2013
Abstract RNA modifications, especially methylation of the N6 position of adenosine (A)—m6A, represent an emerging research frontier in RNA biology. With the rapid development of high-throughput sequencing technology, in-depth study of m6A distribution and function relevance becomes feasible.
Li, Yuli, Song, Shuhui, Li, Cuiping, Yu, Jun   +3 more
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Direct RNA sequencing reveals m6A modifications on adenovirus RNA are necessary for efficient splicing

Nature Communications, 2020
Adenovirus transcripts contain N6-methyladenosine (m6A) modification. Here the authors profile m6A modification sites on adenovirus mRNAs using Illumina meRIP-Seq and nanopore direct RNA sequencing, and showcase a role for m6A in splicing of viral late ...
Alexander M. Price, Katharina E. Hayer, Alexa B. R. McIntyre, Nandan S. Gokhale, Jonathan S. Abebe, Ashley N. Della Fera, Christopher E. Mason, Stacy M. Horner, Angus C. Wilson, Daniel P. Depledge, Matthew D. Weitzman   +10 more
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N6-Methyladenosine METTL3 Modulates the Proliferation and Apoptosis of Lens Epithelial Cells in Diabetic Cataract

Molecular Therapy: Nucleic Acids, 2020
N6-methyladenosine (m6A) is the most prevalent eukaryotic messenger RNA modification. Diabetic cataract (DC) is caused by high glucose (HG) in diabetes mellitus. However, the regulatory mechanism of m6A in the DC pathogenesis is poorly understood.
Jun Yang, Jingshu Liu, Shaozhen Zhao, Fang Tian   +3 more
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The Alteration of m6A Modification at the Transcriptome-Wide Level in Human Villi During Spontaneous Abortion in the First Trimester

Frontiers in Genetics, 2022
A growing number of studies have demonstrated that N6 methyladenine (m6A) acts as an important role in the pathogenesis of reproductive diseases. Therefore, it is essential to profile the genome-wide m6A modifications such as in spontaneous abortion.
Jiajie She, Jiajie She, Kaifen Tan, Jie Liu, Shuo Cao, Zengguang Li, You Peng, Zhuoyu Xiao, Ruiying Diao, Liping Wang   +9 more
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