Results 61 to 70 of about 4,546 (178)

Comprehensive Analysis of N6-Methyladenosine (m6A) Methylation in Neuromyelitis Optica Spectrum Disorders

Frontiers in Genetics, 2021
Background: N6-Methyladenosine (m6A) methylation is the most prevalent internal posttranscriptional modification on mammalian mRNA. But its role in neuromyelitis optica spectrum disorders (NMOSD) is not known.Aims: To explore the mechanism of m6A in ...
Hong Yang, Yi-Fan Wu, Jie Ding, Wei Liu, De-Sheng Zhu, Xia-Feng Shen, Yang-Tai Guan, Yang-Tai Guan   +7 more
doaj   +1 more source

High N6-methyladenosine-activated TCEAL8 mRNA is a novel pancreatic cancer marker [PDF]

N6-methyladenosine (m6A) is an RNA modification involved in RNA processing and widely found in transcripts. In cancer cells, m6A is upregulated, contributing to their malignant transformation.
Arao, Yasuko, Doki, Yuichiro, Eguchi, Hidetoshi, Hara, Tomoaki, Ishii, Hideshi, Kitagawa, Toru, Kobayashi, Shogo, Meng, Sikun, Mori, Masaki, Motooka, Daisuke, Ofusa, Ken, Ogawa, Kazuhiko, Rennie, Sarah, Sasaki, Kazuki, Sato, Hiromichi, Suzuki, Yutaka, Takahashi, Hidenori, Takeda, Yu, Tatekawa, Shotaro, Tsuji, Yoshiko, Uchida, Shizuka, Yamada, Daisaku   +21 more
core   +2 more sources

Mechanism of METTL14-mediated ERα m6A regulation of endometrial cancer metastasis [PDF]

, 2023
Background and purpose: Aberrant N6-methyladenosine (m6A) modification caused by dysregulation of methyltransferase-like factor 14 (METTL14) plays an important role in the progression of various cancers, and it is unclear whether it is involved in the ...
ZHAO Manying, WU Dongyue, DU Ruiting, YIN Lu, LUO Yulu
core   +1 more source

Comprehensive analysis of the transcriptome-wide m6A methylome in colorectal cancer by MeRIP sequencing

Epigenetics, 2021
Accumulating evidence has demonstrated that N6-methyladenosine (m6A) plays important roles in various cancers, making it essential to profile m6A modifications at a transcriptome-wide scale in colorectal cancer (CRC).
Zhen Zhang, Quan Wang, Mengmeng Zhang, Wei Zhang, Long Zhao, Changjiang Yang, Bo Wang, Kewei Jiang, Yingjiang Ye, Zhanlong Shen, Shan Wang   +10 more
doaj   +1 more source

m7GHub: deciphering the location, regulation and pathogenesis of internal mRNA N7-methylguanosine (m7G) sites in human [PDF]

, 2020
Motivation Recent progress in N7-methylguanosine (m7G) RNA methylation studies has focused on its internal (rather than capped) presence within mRNAs. Tens of thousands of internal mRNA m7G sites have been identified within mammalian transcriptomes, and ...
Chen, Kunqi, de Magalhaes, Joao Pedro, Lu, Zhiliang, Meng, Jia, Rigden, Daniel J, Rong, Rong, Song, Bowen, Su, Jionglong, Tang, Yujiao, Wei, Zhen   +9 more
core   +1 more source

M6A RNA methylation in diabetes induced endothelial damage and ischaemic disease [PDF]

, 2023
Diabetes mellitus exposes endothelial cells (ECs) to a chronic hyperglycaemic milieu, leading to dysfunction of the vascular endothelium. The resulting microvasculature rarefaction leads to tissue hypoperfusion and propagates the occurrence of ischaemic ...
Sweaad, Walid Khalid
core   +1 more source

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source

N6-methyladenosine modification of THBS1 induced by affluent WTAP promotes Graves’ ophthalmopathy progression through glycolysis to affect Th17/Treg balance

Autoimmunity
Graves’ ophthalmopathy (GO) obvious manifestation is the imbalance of Th17/Treg. N6-methyladenosine (m6A) methylation is an important regulator of Th17/Treg balance.
Lin-na Li, Jie-man Wu, Zong-ji Zheng, Shu-xian Li, Meng-yi Cai, Meng-chen Zou   +5 more
doaj   +1 more source

METTL14 is required for exercise-induced cardiac hypertrophy and protects against myocardial ischemia-reperfusion injury [PDF]

, 2022
RNA m6A modification is the most widely distributed RNA methylation and is closely related to various pathophysiological processes. Although the benefit of regular exercise on the heart has been well recognized, the role of RNA m6A in exercise training ...
Feng, Jingyi, Lehmann, H. Immo, Li, Guoping, Sluijter, Joost P.G., Wang, Jiaqi, Wang, Lijun, Wang, Tianhui, Xiao, Junjie, Xu, Gui e., Yu, Pujiao, Zhao, Xuan   +10 more
core   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source