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Merkel cell polyomavirus and Merkel cell carcinoma [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2017 Merkel cell polyomavirus (MCPyV) causes the highly aggressive and relatively rare skin cancer known as Merkel cell carcinoma (MCC). MCPyV also causes a lifelong yet relatively innocuous infection and is one of 14 distinct human polyomaviruses species ...
James A Decaprio
exaly +4 more sources
Prevalence of Merkel cell polyomavirus in Merkel cell carcinoma [PDF]
Modern Pathology, 2009 It has recently been shown that Merkel cell carcinoma, a rare and often lethal cutaneous malignancy, frequently harbors a novel clonally integrated polyomavirus aptly named Merkel cell polyomavirus. We aimed to study the prevalence of Merkel cell polyomavirus in cases of Merkel cell carcinoma, using specimens from formalin-fixed, paraffin-embedded ...
Eric J Duncavage +2 more
exaly +3 more sources
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Merkel Cell Polyomavirus and Human Merkel Cell Carcinoma
2020Merkel cell polyomavirus (MCPyV) is the most recently discovered human oncogenic virus. MCPyV asymptomatically infects most of the human population. In the elderly and immunocompromised, however, it can cause a highly lethal form of human skin cancer called Merkel cell carcinoma (MCC).
Wei, Liu, Jianxin, You
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Detection of Merkel cell polyomavirus DNA in Merkel cell carcinomas
British Journal of Dermatology, 2009Merkel cell carcinoma (MCC) is a rare, aggressive tumour for which an increasing incidence has been reported. A new human polyomavirus, Merkel cell polyomavirus (MCV), was recently isolated from these tumours by applying digital transcriptome subtraction methodology.To detect the presence or absence of MCV in MCCs and other, randomly selected neoplasms.
Maria Kiss, Lajos Kemény
exaly +3 more sources
Detection of Merkel cell polyomavirus in Merkel cell carcinoma and Kaposi's sarcoma
Journal of Medical Virology, 2009AbstractMerkel cell carcinoma is a rare malignancy that sometimes occurs in the skin of elderly people. Recently, a new human polyomavirus, Merkel cell polyomavirus (MCPyV) was identified in Merkel cell carcinoma. In the present study, MCPyV‐DNA was detected in 6 of 11 (55%) cases of Merkel cell carcinoma by nested PCR and real‐time PCR. Histologically,
Harutaka Katano +2 more
exaly +3 more sources
2014
Merkel cell polyomavirus (MCV) is a recently discovered member of the polyomaviridae, a family of small DNA viruses that replicate in the nucleus of their host cell. MCV is one of at least 12 polyomaviruses that naturally infect humans, and furthermore one of four polyomaviruses that are known to cause severe human disease, predominantly in ...
Nicole Fischer, Adam Grundhoff
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Merkel cell polyomavirus (MCV) is a recently discovered member of the polyomaviridae, a family of small DNA viruses that replicate in the nucleus of their host cell. MCV is one of at least 12 polyomaviruses that naturally infect humans, and furthermore one of four polyomaviruses that are known to cause severe human disease, predominantly in ...
Nicole Fischer, Adam Grundhoff
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2011
Merkel cell carcinoma (MCC) is the most aggressive tumor of the skin. Nevertheless, until recently, almost only dermatologists were aware of MCC which was due to the rareness of this neuroendocrine carcinoma. This, however, changed in 2008 when a new polyomavirus, which was named Merkel cell polyomavirus (MCV or MCPyV), was found associated with MCC ...
David Schrama, Jürgen C. Becker
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Merkel cell carcinoma (MCC) is the most aggressive tumor of the skin. Nevertheless, until recently, almost only dermatologists were aware of MCC which was due to the rareness of this neuroendocrine carcinoma. This, however, changed in 2008 when a new polyomavirus, which was named Merkel cell polyomavirus (MCV or MCPyV), was found associated with MCC ...
David Schrama, Jürgen C. Becker
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American Journal of Surgical Pathology, 2009
The recently described Merkel cell polyomavirus (MCPyV) is reportedly present in 50% to 80% of Merkel cell carcinomas (MCC). Although the virus has been shown to be absent from other cutaneous neoplasms, its association with malignancies that are histologically similar to MCC, specifically small cell carcinoma of the lung and other high-grade ...
Eric J, Duncavage +3 more
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The recently described Merkel cell polyomavirus (MCPyV) is reportedly present in 50% to 80% of Merkel cell carcinomas (MCC). Although the virus has been shown to be absent from other cutaneous neoplasms, its association with malignancies that are histologically similar to MCC, specifically small cell carcinoma of the lung and other high-grade ...
Eric J, Duncavage +3 more
openaire +2 more sources
Genetic variability and integration of Merkel cell polyomavirus in Merkel cell carcinoma
Virology, 2012 Merkel cell polyomavirus (MCPyV) is associated to Merkel cell carcinoma (MCC). We studied 113 MCC tumoral skin lesions originating from 97 patients. MCPyV detection was higher in fresh-frozen (FF) biopsies (94%) than in formalin-fixed paraffin-embedded biopsies (39-47%).
G Tomasic, P Vielh, G Jouvion
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Human Pathology, 2013
Merkel cell polyomavirus (MCPyV) monoclonally integrates into genomes of approximately 80% of Merkel cell carcinomas (MCCs) and undergoes mutation. We previously demonstrated statistically significant differences in tumor cell morphology and biology between MCPyV-positive and MCPyV-negative MCCs. We reassessed the usefulness of our morphologic criteria
Takeshi Iwasaki +2 more
exaly +3 more sources
Merkel cell polyomavirus (MCPyV) monoclonally integrates into genomes of approximately 80% of Merkel cell carcinomas (MCCs) and undergoes mutation. We previously demonstrated statistically significant differences in tumor cell morphology and biology between MCPyV-positive and MCPyV-negative MCCs. We reassessed the usefulness of our morphologic criteria
Takeshi Iwasaki +2 more
exaly +3 more sources