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Prevalence of Merkel cell polyomavirus in Merkel cell carcinoma [PDF]

open access: yesModern Pathology, 2009
It has recently been shown that Merkel cell carcinoma, a rare and often lethal cutaneous malignancy, frequently harbors a novel clonally integrated polyomavirus aptly named Merkel cell polyomavirus. We aimed to study the prevalence of Merkel cell polyomavirus in cases of Merkel cell carcinoma, using specimens from formalin-fixed, paraffin-embedded ...
John D Pfeifer, Eric J Duncavage
exaly   +3 more sources
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Merkel Cell Polyomavirus and Human Merkel Cell Carcinoma

2020
Merkel cell polyomavirus (MCPyV) is the most recently discovered human oncogenic virus. MCPyV asymptomatically infects most of the human population. In the elderly and immunocompromised, however, it can cause a highly lethal form of human skin cancer called Merkel cell carcinoma (MCC).
Wei, Liu, Jianxin, You
openaire   +2 more sources

Detection of Merkel cell polyomavirus DNA in Merkel cell carcinomas

British Journal of Dermatology, 2009
Merkel cell carcinoma (MCC) is a rare, aggressive tumour for which an increasing incidence has been reported. A new human polyomavirus, Merkel cell polyomavirus (MCV), was recently isolated from these tumours by applying digital transcriptome subtraction methodology.To detect the presence or absence of MCV in MCCs and other, randomly selected neoplasms.
Lajos Kemény, M Kiss, E Varga
exaly   +3 more sources

Detection of Merkel cell polyomavirus in Merkel cell carcinoma and Kaposi's sarcoma

Journal of Medical Virology, 2009
AbstractMerkel cell carcinoma is a rare malignancy that sometimes occurs in the skin of elderly people. Recently, a new human polyomavirus, Merkel cell polyomavirus (MCPyV) was identified in Merkel cell carcinoma. In the present study, MCPyV‐DNA was detected in 6 of 11 (55%) cases of Merkel cell carcinoma by nested PCR and real‐time PCR. Histologically,
Yoshio Suzuki   +2 more
exaly   +3 more sources

Merkel Cell Polyomavirus

2011
Merkel cell carcinoma (MCC) is the most aggressive tumor of the skin. Nevertheless, until recently, almost only dermatologists were aware of MCC which was due to the rareness of this neuroendocrine carcinoma. This, however, changed in 2008 when a new polyomavirus, which was named Merkel cell polyomavirus (MCV or MCPyV), was found associated with MCC ...
David Schrama, Jürgen C. Becker
openaire   +1 more source

Merkel Cell Polyomavirus

2014
Merkel cell polyomavirus (MCV) is a recently discovered member of the polyomaviridae, a family of small DNA viruses that replicate in the nucleus of their host cell. MCV is one of at least 12 polyomaviruses that naturally infect humans, and furthermore one of four polyomaviruses that are known to cause severe human disease, predominantly in ...
Nicole Fischer, Adam Grundhoff
openaire   +1 more source

Merkel Cell Polyomavirus

American Journal of Surgical Pathology, 2009
The recently described Merkel cell polyomavirus (MCPyV) is reportedly present in 50% to 80% of Merkel cell carcinomas (MCC). Although the virus has been shown to be absent from other cutaneous neoplasms, its association with malignancies that are histologically similar to MCC, specifically small cell carcinoma of the lung and other high-grade ...
Eric J, Duncavage   +3 more
openaire   +2 more sources

Genetic variability and integration of Merkel cell polyomavirus in Merkel cell carcinoma

open access: yesVirology, 2012
Merkel cell polyomavirus (MCPyV) is associated to Merkel cell carcinoma (MCC). We studied 113 MCC tumoral skin lesions originating from 97 patients. MCPyV detection was higher in fresh-frozen (FF) biopsies (94%) than in formalin-fixed paraffin-embedded biopsies (39-47%).
Caroline Robert, G Jouvion, G Tomasic
exaly   +3 more sources

Merkel Cell Polyomavirus (MCPyV)

2020
No abstract available.
Sofia, Asioli, Ricci, Costantino
openaire   +2 more sources

The prevalence of Merkel cell polyomavirus in Japanese patients with Merkel cell carcinoma

Journal of Dermatological Science, 2013
A novel polyomavirus, the Merkel cell polyomavirus (MCPyV) has been implicated in the pathogenesis of Merkel cell carcinoma (MCC); however, the prevalence of MCPyV in Japan has not been extensively investigated.To clarify the prevalence of MCPyV in Japanese patients with MCC.MCPyV DNA was examined by polymerase chain reaction (PCR) in formalin-fixed ...
Tomoyasu, Hattori   +12 more
openaire   +2 more sources

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