Results 31 to 40 of about 2,951 (216)
Biosynthesis of a bacterial meroterpenoid reveals a non-canonical class II meroterpenoid cyclase. [PDF]
Chem SciAtolypene A assembles through sequential epoxidation, prenylation, and cyclization. In vitro studies revealed that AtoE, a noncanonical class II meroterpenoid cyclase, utilizes the first Glu in the atypical xxxE314TAE motif to protonate an oxirane.
Wang Z +9 more
europepmc +3 more sources
Angewandte Chemie, 2020 AbstractFungal meroterpenoids are a diverse group of hybrid natural products with impressive structural complexity and high potential as drug candidates. In this work, we evaluate the promiscuity of the early structure diversity‐generating step in fungal meroterpenoid biosynthetic pathways: the multibond‐forming polyene cyclizations catalyzed by the ...
Takaaki Mitsuhashi +11 more
openaire +5 more sources
Antioxidant Activity of Natural Hydroquinones
Antioxidants, 2022 Secondary metabolites derived from hydroquinone are quite rare in nature despite the original simplicity of its structure, especially when compared to other derivatives with which it shares biosynthetic pathways.
Rosa M. Giner +2 more
doaj +1 more source
Biosynthesis of fungal meroterpenoids
Natural Product Reports, 2016 Biosynthetic pathways and mechanisms of biologically active and/or structurally intriguing fungal meroterpenoids are summarized and discussed.
Yudai, Matsuda, Ikuro, Abe
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Divergent Strategy in Marine Tetracyclic Meroterpenoids Synthesis [PDF]
Marine Drugs, 2021 The divergent total synthesis strategy can be successfully applied to the preparation of families of natural products using a common late-stage pluripotent intermediate. This approach is a powerful tool in organic synthesis as it offers opportunities for the efficient preparation of structurally related compounds.
Antonio Rosales Martínez +2 more
openaire +5 more sources
Bioactive Ascochlorin Analogues from the Marine-Derived Fungus Stilbella fimetaria
Marine Drugs, 2021 The marine-derived fungus Stilbella fimetaria is a chemically talented fungus producing several classes of bioactive metabolites, including meroterpenoids of the ascochlorin family.
Karolina Subko +5 more
doaj +1 more source
A radical approach to diverse meroterpenoids [PDF]
Nature Chemistry, 2020 Meroterpenoids are mixed terpenoid–polyketide natural products with a variety of biological activities. Now, a synthetic approach that combines biocatalytic oxidation with a range of other radical-based reactions enables the divergent synthesis of eight oxidized meroterpenoid natural products and one analogue.
Gomm, A, Nelson, A
openaire +2 more sources
Frontiers in Chemistry, 2021 Ganoderma fungi as popular raw materials of numerous functional foods have been extensively investigated. In this study, five pairs of meroterpenoid enantiomers beyond well-known triterpenoids and polysaccharides, dayaolingzhiols I−M (1–5), were ...
Jiao-Jiao Zhang +7 more
doaj +1 more source
Angewandte Chemie, EarlyView.Achieving selective (sp3)C–H hydroxylation can streamline the synthesis of complex organic molecules. Biocatalysis presents an opportunity to realize this transformation, however, identifying useful enzymes that enable synthetic strategies can be a challenge due to limitations in enzyme substrate scope.
Gonzalo J. Villegas Rodríguez +5 more
wiley +2 more sources
Angewandte Chemie, Volume 138, Issue 30, 20 July 2026.Epimer discrimination remains challenging due to subtle NMR differences. Here, we propose a methodology based on 13C‐RCSA and RDC anisotropic parameters, enabling the assignment of two flexible tetraprenyltoluquinol epimers (1a and 1b) with remote stereoclusters.
Juan Carlos C. Fuentes‐Monteverde +6 more
wiley +2 more sources