Results 11 to 20 of about 2,951 (216)

Meroterpenoids from Terrestrial and Marine Fungi: Promising Agents for Neurodegenerative Disorders—An Updated Review [PDF]

Current Issues in Molecular Biology
Background: Meroterpenoids represent a remarkably diverse class of natural secondary metabolites, some of which are synthesized via terpenoid biosynthetic pathways. Over the past ten years, these compounds have gained interest because of their wide range
Daniela Dimitrova, Simeonka Dimitrova, Gabriela Kehayova, Stela Dragomanova   +3 more
doaj   +3 more sources

Novel polycyclic meroterpenoids with protein tyrosine phosphatase 1B inhibitory activity isolated from desert-derived fungi Talaromyces sp. HMT-8 [PDF]

Natural Products and Bioprospecting
Seven previously undescribed polycyclic meroterpenoids talarines K–Q (1–7), along with five known ones (8–12), were isolated from desert-derived fungi Talaromyces sp. HMT-8. The structure of the novel compounds were elucidated using spectroscopic methods,
Xin-yi Zhai, Jin-jie Liu, Cui-duan Wang, Yi-fan Dou, Jian-hua Lv, Li-an Wang, Jin-xiu Zhang, Zhuang Li   +7 more
doaj   +3 more sources

Identification and Reconstitution of the First Two Enzymatic Steps for the Biosynthesis of Bioactive Meroterpenoids from Hericium erinaceus (Lion’s Mane Mushroom) [PDF]

Molecules
Hericium erinaceus (Lion’s Mane mushroom) is widely consumed for its numerous reported benefits for brain health. A growing body of evidence suggests that these benefits are likely attributable to aromatic compounds contained in its fruiting bodies ...
Riccardo Iacovelli, Fons Poon, Kristina Haslinger   +2 more
doaj   +3 more sources

Meroterpenoids from Marine Sponge Hyrtios sp. and Their Anticancer Activity against Human Colorectal Cancer Cells [PDF]

Marine Drugs
Two new meroterpenoids, hyrtamide A (1) and hyrfarnediol A (2), along with two known ones, 3-farnesyl-4-hydroxybenzoic acid methyl ester (3) and dictyoceratin C (4), were isolated from a South China Sea sponge Hyrtios sp. Their structures were elucidated
Jie Wang, Yue-Lu Yan, Xin-Yi Yu, Jia-Yan Pan, Xin-Lian Liu, Li-Li Hong, Bin Wang   +6 more
doaj   +3 more sources

Progress in the Chemistry of Macrocyclic Meroterpenoids [PDF]

Plants, 2020
In the last decade, the chemistry of meroterpenoids—conjugated molecules formed from isoprenyl fragments through biosynthetic pathways—has developed rapidly.
Dmitriy N. Shurpik, Alan A. Akhmedov, Peter J. Cragg, Vitaliy V. Plemenkov, Ivan I. Stoikov   +4 more
doaj   +3 more sources

Two New Andrastin-Type Meroterpenoids from Marine Sponge-Derived Fungus Botryosporium sp. S5I2-1 [PDF]

Molecules
Botryomeroterpenoids A (1) and B (2), two new andrastin-type meroterpenoids, along with two known analogues (3 and 4), were isolated from sponge-derived fungus Botryosporium sp. S5I2-1.
Hui-Xian Liang, Wan-Ying Guo, Shi-Hai Xu, Bing-Xin Zhao   +3 more
doaj   +2 more sources

Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology

Biomolecules, 2021
Meroterpenoids are secondary metabolites formed due to mixed biosynthetic pathways which are produced in part from a terpenoid co-substrate. These mixed biosynthetically hybrid compounds are widely produced by bacteria, algae, plants, and animals ...
Muhammad Saleem, Frank Surup, Muhammad Saleem   +2 more
exaly   +3 more sources

Collective Total Synthesis of Four <i>Ganoderma</i> Meroterpenoids Based on an Intramolecular Aldol Strategy. [PDF]

Org Lett
The total synthesis of four Ganoderma meroterpenoids (lingzhiol, sinensilactam A, lingzhilactone B, and applanatumol I) has been accomplished from a known olefinic lactone in much shorter steps (4–8 steps) and markedly improved overall yields (15–27 ...
Meguro Y, Oyake M, Enomoto M, Kuwahara S.   +3 more
europepmc   +2 more sources

From natural laboratory to drug discovery: Chemical structures, bioactivities, and biosynthesis of meroterpenoids from <i>Ganoderma</i> species. [PDF]

Chin Herb Med
Meroterpenoids are secondary metabolites partially derived from the terpenoid biosynthetic pathway, and are widely distributed in plants, animals, and fungi. These natural products possess complex backbone structures and diverse bioactivities.
Peng S, Qi J, Lin C, Xu Z, Li Z, Liu C.
europepmc   +2 more sources

A General Entry to <i>Ganoderma</i> Meroterpenoids: Synthesis of Applanatumol E, H, and I, Lingzhilactone B, Meroapplanin B, and Lingzhiol. [PDF]

Org Lett
Ganoderma meroterpenoids are fungal derived hybrid natural product class containing a 1,2,4-trisubstituted benzene ring and a polycyclic terpenoid part.
Rode A, Müller N, Kováč O, Wurst K, Magauer T.   +4 more
europepmc   +2 more sources