Paxillin is crucial for thymus and parathyroid development by regulating the architecture of the third pharyngeal pouch endoderm. [PDF]
Iacolare O +6 more
europepmc +1 more source
Escaping Constraints to Innovate: Maternal Neofunctionalization in a HoxB4 Duplicate
Whole‐genome duplication in Xenopus laevis generated duplicated Hox genes that are largely constrained in sequence and developmental expression. However, HoxB4L uniquely acquired maternal expression through cis‐regulatory and protein structural divergence, illustrating how gene duplication enables transcription factors to escape pleiotropic constraints
Júlia de Lima Carvalho +2 more
wiley +1 more source
VGLL1 contributes to both the transcriptome and epigenome of the developing trophoblast compartment. [PDF]
Calderon RI +21 more
europepmc +1 more source
A Clearer Picture: Using Fetal MRI to Diagnose Neck Masses and Predict Airway Compromise
ABSTRACT Introduction Fetal neck masses are rare but can be life‐threatening if causing airway compromise. Early and accurate diagnosis of these masses allows life‐saving interventions to be undertaken at birth in the form of the EXIT procedure. Methods A single institution case series of all patients referred for fetal MRI to a tertiary center in the ...
Louise Wilson +2 more
wiley +1 more source
Protocol for differentiation of vascular smooth muscle cells from human iPSCs and their application in CRISPRa-mediated gene regulation. [PDF]
Priesmeier L, Tiburcy M, Zelarayán LC.
europepmc +1 more source
Mesenchymal stromal cell‐and fibroblast‐expressing Linx paralogue (Meflin) is expressed in embryonic meninges and contributes to meningeal homeostasis. In meningiomas, elevated Meflin correlates with higher grade and recurrence. Single‐cell RNA sequencing revealed a Meflin‐high tumor cell subset marked by reduced proliferation, WNT6 expression, and ...
Yukihiro Shiraki +13 more
wiley +1 more source
Construction and Expression Analysis of the <i>bin <sup>3xOllas</sup></i> Tool Line. [PDF]
Yi M +3 more
europepmc +1 more source
Vascularised Brain Organoids: Engineering Strategies and Neurobiological Applications
This review highlights emerging strategies to engineer vascularized brain organoids—including endothelial co‐culture, genetic induction, perfusion systems, and in vivo transplantation—and their applications in modelling neurovascular diseases, evaluating BBB drug delivery, and advancing regenerative medicine.
Yeajin Song +4 more
wiley +1 more source
BMP4 initiates and patterns ventral-caudal structures in zebrafish and human pluripotent stem cell aggregates. [PDF]
Xing YY +14 more
europepmc +1 more source

