Results 261 to 270 of about 99,345 (353)

The roles of TGF-β, Wnt, and MAPK signaling pathways in joint lineage specification in vitro and ex vivo. [PDF]

Stem Cell Reports
Raj S, Cutia T, Menghini S, Alemany-Ribes M, Cai J, Young M, Jachim SK, Capellini TD, Craft AM.   +8 more
europepmc   +1 more source

Seamless and Highly Efficient Site‐directed Mutagenesis for Protein, RNA, and Plasmid Engineering

Current Protocols, Volume 6, Issue 1, January 2026.
Abstract Site‐directed mutagenesis is indispensable for protein, RNA, and plasmid engineering. It is ideal to carry out such mutagenesis at an efficiency close to 100%, but many current methods fail to reach this goal and thus require extensive screening efforts.
Xiang‐Jiao Yang
wiley   +1 more source

In Vivo Models of Cardiovascular Disease: <i>Drosophila melanogaster</i> as a Genetic Model of Congenital Heart Disease. [PDF]

Biomedicines
Stougiannou TM, Koutini M, Mitropoulos F, Karangelis D.   +3 more
europepmc   +1 more source

Synthetic lethality in cancer therapy: Mechanisms, models and clinical translation for overcoming therapeutic resistance

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Application of synthetic lethality screening in drug resistance models. Abstract Background and Rationale Synthetic lethality (SL)‐based strategies hold significant promise for overcoming therapeutic resistance, a critical bottleneck in cancer treatment where cancer cells evade anticancer therapies, leading to diminished efficacy or treatment failure ...
Junyan Li, Liyuan Zhang, Yan Shang, Juan Liu, Hailong Zhao   +4 more
wiley   +1 more source

CITED Proteins in Cardiac Development and Lifelong Heart Function. [PDF]

J Pers Med
Bragança J, Cabrita Pinto RL, Ventura I, Ferreira S, Marreiros A.   +4 more
europepmc   +1 more source

Cellular Dynamics after Injection of Mesoderm-Derived Human Embryonic Kidney 293 Cells and Fibroblasts into Developing Chick Embryos

, 2014
Tae Sub Park, Jeong Mook Lim, Ki Hyun Kim, Hee Seung Kim, Yong Sang Song, Jae Yong Han   +5 more
openalex   +2 more sources

Mastering Organoid Growth: A Complete Guide to Overcoming Methodological Challenges

MedComm, Volume 7, Issue 1, January 2026.
Organoids offer transformative 3D models that precisely mimic human organ architecture and function. This review details the latest methodology, emphasizing the cultivation of liver and other abdominal organoids. We analyze technological challenges (e.g., nutrient delivery, scalability, diversity) and provide practical insights for new researchers ...
Chunbao Jiao, Omer Faruk Karakaya, Neda Dadgar, Chase J. Wehrle, Zahra Massoud, Hanna Hong, Robert L. Fairchild, Nic Leipzig, Federico Aucejo, Wen Wee Ma, Jan Joseph Melenhorst, Sofia Ferreira Gonzales, Andrea Schlegel   +12 more
wiley   +1 more source

Organoids in Cancer Research and Regenerative Medicine: Current Status, Challenges, and Future Prospects

MedComm, Volume 7, Issue 1, January 2026.
The management of cancer and tissue regeneration remains a substantial challenge to global health. Organoids, which are stem cell‐derived three‐dimensional multicellular structures, are revolutionizing biomedical research. Therefore, this review highlights their applications in cancer research and regenerative medicine, while discussing current ...
Ruiyang Li, Yuezhou Wu, Zhu'anzhen Zheng, Fengjin Zhou, Ke Xu, Jiacan Su   +5 more
wiley   +1 more source

P-LM421E8, the heparan sulfate chain-conjugated laminin-421-E8 fragment, drives differentiation of human induced pluripotent stem cells into hematopoietic progenitor cells comparable to basic fibroblast growth factor in a chemically defined system. [PDF]

Matrix Biol Plus
Ninomiya N, Sasaki K, Katori R, Shimizu Y, Fujita K, Taniguchi Y, Kunieda T, Tamura K, Yamada M, Sekiguchi K, Kimura H.   +10 more
europepmc   +1 more source

Corneal Nerve Regeneration via MSC‐Derived EVs: Tissue Source and Culture Dimensionality Dictate miRNA Cargo and Therapeutic Efficacy

Small, Volume 22, Issue 6, 27 January 2026.
Mesenchymal stem cell‐derived extracellular vesicles (EVs) from human cornea and bone marrow, cultured in 2D and 3D conditions, are characterized and tested for corneal nerve repair. 3D‐derived EVs show superior therapeutic efficacy and in vivo reinnervation.
Hamed Massoumi, Eitan A. Katz, Melinda Alviar, Qiang Zhou, Mauricio Gonzalez Oyarzun, Deepshikha Tewari, Makayla Dove, Hanieh Niktinat, Tara Nguyen, Seyed Mahbod Baharnoori, Khandaker Anwar, Mark Maienschein Cline, Yuanxiang Li, Xiaowei Wang, Victor H. Guaiquil, Mark I. Rosenblatt, Ali R. Djalilian, Elmira Jalilian   +17 more
wiley   +1 more source