Results 131 to 140 of about 1,077,952 (298)

Glucose Metabolic Reprogramming in Colorectal Cancer: From Mechanisms to Targeted Therapy Approaches

Cancer Medicine
Background Colorectal cancer (CRC) is one of the most common malignant tumors, and its morbidity ranks third among all cancers, with a trend toward younger patients.
Runkai Zhou, Fazhi Wang, Jiazhe Wen, Xuefeng Zhou, Yugang Wen   +4 more
doaj   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Erratum to: Obesity and type 2 diabetes have additive effects on left ventricular remodelling in normotensive patients-a cross sectional study

Cardiovascular Diabetology, 2017
Kirstie A. De Jong, Juliane K. Czeczor, Smithamol Sithara, Kevin McEwen, Gary D. Lopaschuk, Alan Appelbe, Kimberly Cukier, Mark Kotowicz, Sean L. McGee   +8 more
doaj   +1 more source

The role of acetylation and deacetylation in cancer metabolism

Clinical and Translational Medicine
As a hallmark of cancer, metabolic reprogramming adjusts macromolecular synthesis, energy metabolism and redox homeostasis processes to adapt to and promote the complex biological processes of abnormal growth and proliferation.
Cuicui Wang, Xiaoxin Ma
doaj   +1 more source

Crosstalk between metabolic reprogramming and microbiota: implications for cancer progression and novel therapeutic opportunities

Frontiers in Immunology
Metabolic reprogramming is a process by which cells adapt to the nutrient microenvironment by regulating energy metabolism. Compared with normal cells, tumor cells tend to undergo metabolic reprogramming, which is one of the hallmarks of concurrent ...
Xingchen Li, Yidi Jia, Yanqing Li, Hu Hei, Songtao Zhang, Jianwu Qin   +5 more
doaj   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source

Cancer metabolism: Key players in metabolic reprogramming

Cancer Science, 2013
Over 80 years ago, Warburg discovered that cancer cells generate ATP through the glycolytic pathway, even in the presence of oxygen. The finding of this phenomenon, termed the “Warburg effect,” stimulated much research on tumorigenesis, but few explanations were forthcoming to explain the observation.
openaire   +3 more sources

Metabolic Reprogramming Through Polyphenol Networks: A Systems Approach to Metabolic Inflammation and Insulin Resistance

Obesity-induced insulin resistance and type 2 diabetes mellitus (T2DM) represent complex systemic disorders marked by chronic inflammation, oxidative stress, mitochondrial dysfunction, and endoplasmic reticulum (ER) stress.
Akter, Shamima, Sadman Sazzad, Mohib, Mohammad Mohabbulla, Shawon, Md Jalal Ahmed, Ratin Al Samir, Mohammad Hossain Shariare, Md Fahim Hasan, Sazzad, Sadman, Jawad Ul Karim Mahir, Shamima Akter, Md Jalal Ahmed Shawon, Mohammad Mohabbulla Mohib, Uddin, Mohammad Borhan, Mohammad Sarif Mohiuddin, Jahan, Nadia, Ridoy, Arafath Amin, Shakila Jahan Shimu, Al Samir, Ratin, Arafath Amin Ridoy, Mahir, Jawad Ul Karim, Hasan, Md Fahim, Fardin Al Fahad Shakib, Shimu, Shakila Jahan, Nadia Jahan, Shakib, Fardin Al Fahad, Mohiuddin, Mohammad Sarif, Shariare, Mohammad Hossain, Mohammad Borhan Uddin   +27 more
core   +1 more source

Metabolic Reprogramming in Chloroplasts under Heat Stress in Plants

, 2018
Increases in ambient temperatures have been a severe threat to crop production in many countries around the world under climate change. Chloroplasts serve as metabolic centers and play a key role in physiological adaptive processes to heat stress.
Fang-Qing Guo, Ning-Yu He, Qing-Long Wang, Juan-Hua Chen   +3 more
core   +1 more source