Results 121 to 130 of about 192,395 (356)

Bibliometrics and scientometrics analysis of exosomes relevance in hepatocellular carcinoma (2014-2024)

Frontiers in Oncology
BackgroundExosomes have emerged as pivotal players in the pathogenesis, progression, and treatment of hepatocellular carcinoma (HCC), establishing them as a major research focus in recent years. This bibliometric analysis maps the knowledge evolution and
Kaikui Wu, Kaikui Wu, Kaikui Wu, Guiya Lu, Guiya Lu, Guiya Lu, Ruijun Guo, Ruijun Guo, Chunxia Li, Chunxia Li, Minglin Ou, Minglin Ou   +11 more
doaj   +1 more source

Triterpenoid ursolic acid drives metabolic rewiring and epigenetic reprogramming in treatment/prevention of human prostate cancer

, 2021
Shanyi Li, Renyi Wu, Lujing Wang, Hsiao‐Chen Dina Kuo, Davit Sargsyan, Xi Zheng, Yujue Wang, Xiaoyang Su, Ah‐Ng Tony Kong   +8 more
openalex   +2 more sources

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Glucose Metabolic Reprogramming in Colorectal Cancer: From Mechanisms to Targeted Therapy Approaches

Cancer Medicine
Background Colorectal cancer (CRC) is one of the most common malignant tumors, and its morbidity ranks third among all cancers, with a trend toward younger patients.
Runkai Zhou, Fazhi Wang, Jiazhe Wen, Xuefeng Zhou, Yugang Wen   +4 more
doaj   +1 more source

Crosstalk between the tumor immune microenvironment and metabolic reprogramming in pancreatic cancer: new frontiers in immunotherapy

Frontiers in Immunology
In recent years, the incidence and mortality of pancreatic cancer (PC) are increasing year by year. The highly heterogeneous nature of PC, its strong immune escape ability and easy metastasis make it the most lethal malignant tumor in the world. With the
Taijin Shi, Xiaoyan Cui, Junlin Wang, Guangqia Liu, Jiayin Meng, Yingjie Zhang   +5 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

The role of acetylation and deacetylation in cancer metabolism

Clinical and Translational Medicine
As a hallmark of cancer, metabolic reprogramming adjusts macromolecular synthesis, energy metabolism and redox homeostasis processes to adapt to and promote the complex biological processes of abnormal growth and proliferation.
Cuicui Wang, Xiaoxin Ma
doaj   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Crosstalk between metabolic reprogramming and microbiota: implications for cancer progression and novel therapeutic opportunities

Frontiers in Immunology
Metabolic reprogramming is a process by which cells adapt to the nutrient microenvironment by regulating energy metabolism. Compared with normal cells, tumor cells tend to undergo metabolic reprogramming, which is one of the hallmarks of concurrent ...
Xingchen Li, Yidi Jia, Yanqing Li, Hu Hei, Songtao Zhang, Jianwu Qin   +5 more
doaj   +1 more source

Pyruvate dehydrogenase kinase 4‐mediated metabolic reprogramming is involved in rituximab resistance in diffuse large B‐cell lymphoma by affecting the expression of MS4A1/CD20

, 2021
Duanfeng Jiang, Qiuyu Mo, Xiaoying Sun, Xiaotao Wang, Min Dong, Guozhen Zhang, Fangping Chen, Qiangqiang Zhao   +7 more
openalex   +1 more source