Results 101 to 110 of about 1,077,952 (298)

Bibliometrics and scientometrics analysis of exosomes relevance in hepatocellular carcinoma (2014-2024)

Frontiers in Oncology
BackgroundExosomes have emerged as pivotal players in the pathogenesis, progression, and treatment of hepatocellular carcinoma (HCC), establishing them as a major research focus in recent years. This bibliometric analysis maps the knowledge evolution and
Kaikui Wu, Kaikui Wu, Kaikui Wu, Guiya Lu, Guiya Lu, Guiya Lu, Ruijun Guo, Ruijun Guo, Chunxia Li, Chunxia Li, Minglin Ou, Minglin Ou   +11 more
doaj   +1 more source

Metabolic Reprogramming of Stem Cell Epigenetics [PDF]

, 2015
For many years, stem cell metabolism was viewed as a byproduct of cell fate status rather than an active regulatory mechanism; however, there is now a growing appreciation that metabolic pathways influence epigenetic changes associated with lineage ...
Ryall, James G., Cliff, Tim, Sartorelli, Vittorio, Dalton, Stephen   +3 more
core   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Metabolic reprogramming and interventions in angiogenesis

Journal of Advanced Research
Endothelial cell (EC) metabolism plays a crucial role in the process of angiogenesis. Intrinsic metabolic events such as glycolysis, fatty acid oxidation, and glutamine metabolism, support secure vascular migration and proliferation, energy and biomass production, as well as redox homeostasis maintenance during vessel formation.
Yun Liu, Zifang Wu, Yikun Li, Yating Chen, Xuan Zhao, Miaomiao Wu, Yaoyao Xia   +6 more
openaire   +2 more sources

LncRNAs‐circRNAs as Rising Epigenetic Binary Superstars in Regulating Lipid Metabolic Reprogramming of Cancers

Advanced Science
As one of novel hallmarks of cancer, lipid metabolic reprogramming has recently been becoming fascinating and widely studied. Lipid metabolic reprogramming in cancer is shown to support carcinogenesis, progression, distal metastasis, and chemotherapy ...
Shanshan Liu, Benzheng Jiao, Hongguang Zhao, Xinyue Liang, Fengyan Jin, Xiaodong Liu, Ji‐Fan Hu   +6 more
doaj   +1 more source

A mini-review-cancer energy reprogramming on drug resistance and immune response

Translational Oncology
With the growing interest to harness cancer metabolism and energy reprogramming, this mini review aimed to explain the metabolic programming revealing the mechanisms regarding the treatment resistance.
Chengxiang Liu, Liuxin Yang, Tingting Gao, Xingxing Yuan, Ousman Bajinka, Kuanyu Wang   +5 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Exploring the significance of fatty acid metabolism reprogramming in the pathogenesis of cancer and anticancer therapy

Annals of Medicine
One of the important markers that distinguish tumor cells from normal cells is metabolic reprogramming. Among them, the reprogramming of fatty acid metabolism not only supports the fuel supply for energy but also meets the needs of rapid biosynthesis ...
Jiaao Sun, Jiahua Liu, Feng Chen, Xiaoxi Wang, Guangzhen Wu   +4 more
doaj   +1 more source

Metabolic reprogramming in Nrf2-driven proliferation of normal rat hepatocytes [PDF]

Background and Aims: Cancer cells reprogram their metabolic pathways to support bioenergetic and biosynthetic needs and to maintain their redox balance. In several human tumors, the Keap1-Nrf2 system controls proliferation and metabolic reprogramming by ...
Serra M., Columbano A., Kowalik M. A., Inoue J., Morandi A., Taguchi K., Bacci M., Giordano S., Perra A., Hishinuma E., Koshiba S., Caddeo A., Yamamoto M., Puliga E.   +13 more
core   +1 more source