Results 81 to 90 of about 1,077,952 (298)

MYC Induces a Hybrid Energetics Program Early in Cell Reprogramming

Stem Cell Reports, 2018
Summary: Cell reprogramming is thought to be associated with a full metabolic switch from an oxidative- to a glycolytic-based metabolism. However, neither the dynamics nor the factors controlling this metabolic switch are fully understood.
Javier Prieto, Arnold Y. Seo, Marian León, Fulvio Santacatterina, Laura Torresano, Martina Palomino-Schätzlein, Karen Giménez, Azahara Vallet-Sánchez, Xavier Ponsoda, Antonio Pineda-Lucena, José M. Cuezva, Jennifer Lippincott-Schwartz, Josema Torres   +12 more
doaj   +1 more source

Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment

Journal of Experimental & Clinical Cancer Research, 2023
Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet their growth requirements.
Shiming Tan, Yiqing Yang, Wenjuan Yang, Yaqian Han, Lisheng Huang, Ruiqian Yang, Zifan Hu, Yi Tao, Lin Liu, Yun Li, Linda Oyang, Jinguan Lin, Qiu Peng, Xianjie Jiang, Xuemeng Xu, Longzheng Xia, Mingjing Peng, Nayiyuan Wu, Yanyan Tang, Deliang Cao, Qianjin Liao, Yujuan Zhou   +21 more
doaj   +1 more source

Metabolic Classification and Intervention Opportunities for Tumor Energy Dysfunction

, 2021
A comprehensive view of cell metabolism provides a new vision of cancer, conceptualized as tissue with cellular-altered metabolism and energetic dysfunction, which can shed light on pathophysiological mechanisms.
Rosa Noguera, Tomás Álvaro Naranjo, Sergio Abanades, Fernando Fariñas, Ezequiel Monferrer, Amparo López-Carrasco, López-Carrasco, Amparo, Noguera, Rosa, Vieco-Martí, Isaac, Álvaro Naranjo, Tomás, Isaac Vieco-Martí, Luis de la Cruz-Merino, Fariñas, Fernando, de la Cruz-Merino, Luis, Abanades, Sergio, Monferrer, Ezequiel   +15 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Metabolic Reprogramming of Cancer-Associated Fibroblast in the Tumor Microenvironment: From Basics to Clinic

Clinical Medicine Insights: Oncology
Metabolic reprogramming occurs when tumor cells replenish themselves with nutrients required for growth to meet their metabolic needs. Cancer-associated fibroblasts (CAFs) are activated fibroblasts involved in building the c (TME) to promote tumor ...
Lujia Zhou, Wenjie Zhang, Xiaoxue Hu, Daorong Wang, Dong Tang   +4 more
doaj   +1 more source

Emerging Landscapes of Tumor Immunity and Metabolism

Frontiers in Oncology, 2020
The metabolic reprogramming of cancer tissue has higher metabolic activity than surrounding tissues. At the same time, the local infiltration of immunosuppressive cells is also significantly increased, resulting in a significant decrease in tumor ...
Fan Wu, Ye Cheng, Liangliang Wu, Wenling Zhang, Wubing Zheng, Qian Wang, Hongyong Cao, Xiongxiong Pan, Weiwei Tang   +8 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source