Results 91 to 100 of about 1,077,952 (298)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

PKM2: A gatekeeper in macrophage metabolic reprogramming

Journal of Pharmaceutical Analysis
Metabolic reprogramming serves as a core adaptive mechanism for cells to respond to microenvironmental changes and plays a decisive role in macrophage functional polarization.
Ke Li, Mingyu Wu, Qiuyu Zhang, Jiabin Wu, Xianyi Ding, Weihua Xiao   +5 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Lipid Metabolic Reprogramming in Hepatocellular Carcinoma

, 2018
Metabolic reprogramming for adaptation to the local environment has been recognized as a hallmark of cancer. Although alterations in fatty acid (FA) metabolism in cancer cells have received less attention compared to other metabolic alterations such as ...
Naoto Fujiwara, Kazuhiko Koike, Hayato Nakagawa, Yuki Hayata, Tomoharu Yamada, Satoshi Kawamura   +5 more
core   +1 more source

Similarities in the Metabolic Reprogramming of Immune System and Endothelium [PDF]

, 2017
Cellular metabolism has been known for its role in bioenergetics. In recent years, much light has been shed on the reprogrammable cellular metabolism underlying many vital cellular processes, such as cell activation, proliferation, and differentiation ...
Mauro, Claudio; id_orcid, Mauro, C, Tang, C-Y, Tang, Chu-yik, Claudio Mauro, Chu-Yik Tang   +5 more
core   +1 more source

Metabolic Reprogramming, Questioning, and Implications for Cancer

, 2021
International audienceThe expression “metabolic reprogramming” has been encountered more and more in the literature since the mid-1990s. It seems to encompass several notions depending on the author, but the lack of a clear definition allows it to be ...
Pierre Jacquet, Angélique Stéphanou, Stéphanou, Angélique, Jacquet, Pierre   +3 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Crosstalk between Epigenetics and Metabolic Reprogramming in Metabolic Dysfunction-Associated Steatotic Liver Disease-Induced Hepatocellular Carcinoma: A New Sight

Epigenetic and metabolic reprogramming alterations are two important features of tumors, and their reversible, spatial, and temporal regulation is a distinctive hallmark of carcinogenesis.
Yuqiang Zhao, Peiran Zhao, Jing Yang, Anqi Li, Rui Wang   +4 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Mitochondrial metabolic reprogramming drives diabetic kidney disease progression: cell-specific mechanisms, metabolic memory, and targeted strategies

Molecular Medicine
Diabetic Kidney Disease (DKD), as a major microvascular complication of diabetes, is the leading cause of chronic kidney disease and end-stage kidney disease.
Lingfei Zhang, Yue Zhang, Liu Han, Jialei Wang, Lijie Hou, Songbo Fu   +5 more
doaj   +1 more source