Results 21 to 30 of about 184,184 (276)

The metabolome of human milk is altered differentially by Holder pasteurization and high hydrostatic pressure processing

Frontiers in Nutrition, 2023
The milk metabolome is composed of hundreds of molecules that can impact infant development. In preterm infants, sterilized donor milk (DM) is frequently used for their feeding.
Léa Chantal Tran, Lucie Marousez, Marie De Lamballerie, Scott McCulloch, Emmanuel Hermann, Frédéric Gottrand, Frédéric Gottrand, Delphine Ley, Delphine Ley, Jean Lesage   +9 more
doaj   +1 more source

MetaboTools: A comprehensive toolbox for analysis of genome-scale metabolic models [PDF]

, 2016
Metabolomic data sets provide a direct read-out of cellular phenotypes and are increasingly generated to study biological questions. Our previous work revealed the potential of analyzing extracellular metabolomic data in the context of the metabolic ...
Aurich, Maike K., Fleming, Ronan M. T., Thiele, Ines   +2 more
core   +3 more sources

Systemic Metabolomic Changes in Blood Samples of Lung Cancer Patients Identified by Gas Chromatography Time-of-Flight Mass Spectrometry. [PDF]

, 2015
Lung cancer is a leading cause of cancer deaths worldwide. Metabolic alterations in tumor cells coupled with systemic indicators of the host response to tumor development have the potential to yield blood profiles with clinical utility for diagnosis and ...
Barupal, Dinesh K, Fiehn, Oliver, Gandara, David R, Hanash, Samir M, Kim, Kyoungmi, Miyamoto, Suzanne, Taguchi, Ayumu, Taylor, Sandra L, Wikoff, William R, Wohlgemuth, Gert, Yoneda, Ken Y   +10 more
core   +2 more sources

Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli [PDF]

, 2018
Priming and activating immune stimuli have profound effects on macrophages, however, studies generally evaluate stimuli in isolation rather than in combination.
Achcar, Fiona, Barrett, Michael P., Goodyear, Carl S., Pountain, Andrew W., Rattigan, Kevin M., Regnault, Clement, Vincent, Isabel M.   +6 more
core   +3 more sources

Polymorphie DNA repair genes XRCC1 and XRCC3 and the risk for cervical cancer in Brazilian patients

Brazilian Journal of Oncology, 2017
Background: DNA repair genes play a key role in maintaining genomic stability and integrity. DNA repair gene polymorphisms, such as X-ray repair cross-complementing group 1 and 3 genes (XRCC1 and XRCC3), are implicated to contribute to ...
Fabricio Colacino-Silva, João Paulo Ferreira de Oliveira Kleine, Márcia Batista Salzgeber, Rodrigo de Aquino Castro, Manoel João Batista Castello Girão, Ismael Dale Cotrim Guerreiro da Silva, Paulo D’Amora   +6 more
doaj   +1 more source

PLS2 in Metabolomics [PDF]

Metabolites, 2019
Metabolomics is the systematic study of the small-molecule profiles of biological samples produced by specific cellular processes. The high-throughput technologies used in metabolomic investigations generate datasets where variables are strongly correlated and redundancy is present in the data.
Matteo Stocchero, Emanuela Locci, Ernesto d’Aloja, Matteo Nioi, Eugenio Baraldi, Giuseppe Giordano   +5 more
openaire   +4 more sources

Metabolomics

Current Drug Metabolism, 2008
Metabolomics is based on the simultaneous analysis of multiple low-molecular-weight metabolites from a given sample. The goals of metabolomics are to catalog and quantify the myriad small molecules found in biological fluids under different conditions. The metabolomics represents the collection of all metabolites in a biological organism, and metabolic
V S, Gomase, S S, Changbhale, S A, Patil, K V, Kale   +3 more
openaire   +4 more sources

Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase [PDF]

, 2015
Background Statins are first-line therapy for cardiovascular disease prevention, but their systemic effects across lipoprotein subclasses, fatty acids, and circulating metabolites remain incompletely characterized.
Ala-Korpela, M, Casas, J-P, Chaturvedi, N, Fatemifar, G, Hingorani, AD, Hughes, AD, Jarvelin, M-R, Kahonen, M, Kangas, AJ, Kettunen, J, Kivimaki, M, Lawlor, DA, Lehtimaki, T, Mantyselka, P, Perola, M, Raitakari, OT, Salomaa, V, Sattar, N, Smith, GD, Soininen, P, Tiainen, M, Tillin, T, Tynkkynen, T, Vanhala, M, Wang, Q, Wurtz, P   +25 more
core   +2 more sources

Xenobiotic Metabolomics: Major Impact on the Metabolome [PDF]

Annual Review of Pharmacology and Toxicology, 2012
Xenobiotics are encountered by humans on a daily basis and include drugs, environmental pollutants, cosmetics, and even components of the diet. These chemicals undergo metabolism and detoxication to produce numerous metabolites, some of which have the potential to cause unintended effects such as toxicity.
Caroline H, Johnson, Andrew D, Patterson, Jeffrey R, Idle, Frank J, Gonzalez   +3 more
openaire   +2 more sources

Mass Spectrometry Imaging Reveals Elevated Glomerular ATP/AMP in Diabetes/obesity and Identifies Sphingomyelin as a Possible Mediator

EBioMedicine, 2016
AMP-activated protein kinase (AMPK) is suppressed in diabetes and may be due to a high ATP/AMP ratio, however the quantitation of nucleotides in vivo has been extremely difficult. Via matrix-assisted laser desorption/ionization mass spectrometry imaging (
Satoshi Miyamoto, Cheng-Chih Hsu, Gregory Hamm, Manjula Darshi, Maggie Diamond-Stanic, Anne-Emilie Declèves, Larkin Slater, Subramaniam Pennathur, Jonathan Stauber, Pieter C. Dorrestein, Kumar Sharma   +10 more
doaj   +1 more source