Results 41 to 50 of about 168,925 (309)

A Metabolomics-Based Study on the Discriminative Classification Models and Toxicological Mechanism of Estazolam Fatal Intoxication

Metabolites, 2023
Fatal intoxication with sedative-hypnotic drugs is increasing yearly. However, the plasma drug concentration data for fatal intoxication involving these substances are not systematic and even overlap with the intoxication group.
Xiaohui Dai, Rui Bai, Bing Xie, Jiahong Xiang, Xingang Miao, Yan Shi, Feng Yu, Bin Cong, Di Wen, Chunling Ma   +9 more
doaj   +1 more source

Transcriptomics and metabolomics reveal the molecular and metabolic adaptation to heat stress in Manila clam Ruditapes philippinarum

Frontiers in Marine Science, 2023
Temperature is an important environmental factor affecting metabolism, growth and life activities of marine bivalves. To reveal the molecular and metabolic responses to heat stress, comparative transcriptomics and metabolomics were performed in the ...
Hao Jing, Hao Jing, Hao Jing, Liqing Zhou, Liqing Zhou, Yiqiang Gao, Yiqiang Gao, Yiqiang Gao, Zhihong Liu, Zhihong Liu, Biao Wu, Biao Wu, Xiujun Sun, Xiujun Sun, Kang Tu   +14 more
doaj   +1 more source

Metabolomics-based treatment for chronic diseases: results from a multidisciplinary clinical study

BMJ Nutrition, Prevention & Health
Background Non-communicable diseases (NCDs), known as chronic diseases, significantly impact patients’ quality of life (QoL) and increase medical expenses.
Aristidis Tsatsakis, Dimitris Tsoukalas, Evangelia Sarandi, Vassilleios Fragoulakis, Symeon Xenidis, Maria Mhliopoulou, Maria Charta, Efstathia Paramera, Evangelos Papakonstantinou   +8 more
doaj   +1 more source

Application of clinical blood metabogram for diagnosis of early-stage Parkinson’s disease: a pilot study

Frontiers in Molecular Biosciences
In terms of time, cost, and reproducibility of clinical laboratory tests, a mass spectrometric clinical blood metabogram (CBM) enables the investigation of the blood metabolome.
Petr G. Lokhov, Oxana P. Trifonova, Elena E. Balashova, Dmitry L. Maslov, Michael V. Ugrumov, Alexander I. Archakov   +5 more
doaj   +1 more source

Targeted Metabolomic Analysis of Serum Fatty Acids for the Prediction of Autoimmune Diseases

Frontiers in Molecular Biosciences, 2019
Autoimmune diseases (ADs) are rapidly increasing worldwide and accumulating data support a key role of disrupted metabolism in ADs. This study aimed to identify an improved combination of Total Fatty Acids (TFAs) biomarkers as a predictive factor for the
Dimitris Tsoukalas, Dimitris Tsoukalas, Dimitris Tsoukalas, Vassileios Fragoulakis, Evangelia Sarandi, Evangelia Sarandi, Anca Oana Docea, Evangelos Papakonstaninou, Gerasimos Tsilimidos, Chrysanthi Anamaterou, Persefoni Fragkiadaki, Michael Aschner, Aristidis Tsatsakis, Aristidis Tsatsakis, Nikolaos Drakoulis, Daniela Calina   +15 more
doaj   +1 more source

Effects of Different Monochromatic Light Combinations on Cecal Microbiota Composition and Cecal Tonsil T Lymphocyte Proliferation

Frontiers in Immunology, 2022
Emerging data demonstrated that the gut microbiota plays an important role in protecting the integrity of the epithelial barrier, forming a mucosal immune system, and maintaining intestinal homeostasis through its metabolites.
Yijia Zhang, Zixu Wang, Yulan Dong, Jing Cao, Yaoxing Chen   +4 more
doaj   +1 more source

A novel method for interrogating receiver operating characteristic curves for assessing prognostic tests

Diagnostic and Prognostic Research, 2017
Background Disease prevalence is rarely explicitly considered in the early stages of the development of novel prognostic tests. Rather, researchers use the area under the receiver operating characteristic (AUROC) as the key metric to gauge and report ...
Grégoire Thomas, Louise C. Kenny, Philip N. Baker, Robin Tuytten   +3 more
doaj   +1 more source

Metabolomics in oncology

Cancer Reports, 2023
AbstractBackgroundOncogenic transformation alters intracellular metabolism and contributes to the growth of malignant cells. Metabolomics, or the study of small molecules, can reveal insight about cancer progression that other biomarker studies cannot.
Gurparsad Singh Suri, Gurleen Kaur, Giuseppina M. Carbone, Dheeraj Shinde   +3 more
openaire   +3 more sources

Cell Metabolomics [PDF]

OMICS: A Journal of Integrative Biology, 2013
Abstract Metabolomics technologies enable the examination and identification of endogenous biochemical reaction products, revealing information on the precise metabolic pathways and processes within a living cell. Metabolism is either directly or indirectly involved with every aspect of cell function, and metabolomics is thus believed
Aihua, Zhang, Hui, Sun, Hongying, Xu, Shi, Qiu, Xijun, Wang   +4 more
openaire   +2 more sources

Metabolomics for the masses: The future of metabolomics in a personalized world

European Journal of Molecular & Clinical Medicine, 2017
Current clinical practices focus on a small number of biochemical directly related to the pathophysiology with patients and thus only describe a very limited metabolome of a patient and fail to consider the interations of these small molecules.
Trivedi, Drupad; id_orcid 0000-0001-7969-0195, Hollywood, Katherine; id_orcid 0000-0002-7028-047X, Goodacre, Royston   +2 more
openaire   +4 more sources