Results 61 to 70 of about 168,925 (309)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Laboratory and Metabolomic Fingerprint in Heart Failure with Preserved Ejection Fraction: From Clinical Classification to Biomarker Signature

Biomolecules, 2023
Heart failure with preserved ejection fraction (HFpEF) remains a poorly characterized syndrome with many unknown aspects related to different patient profiles, various associated risk factors and a wide range of aetiologies.
Alberto Palazzuoli, Francesco Tramonte, Matteo Beltrami   +2 more
doaj   +1 more source

Identification of Novel Biomarkers in Late Preterm Neonates with Respiratory Distress Syndrome (RDS) Using Urinary Metabolomic Analysis

, 2023
Urine metabolomics is gaining traction as a means of identifying metabolic signatures associated with health and disease states. Thirty-one (31) late preterm (LP) neonates admitted to the neonatal intensive care unit (NICU) and 23 age-matched healthy LPs
Irene Christopoulou, Konstantina Matzarapi, Anastasia Varvarigou, Eirini Kostopoulou, Styliani A. Chasapi, Georgios A. Spyroulias   +5 more
core   +1 more source

Microbiome and Metabolomics

Medical Journal of Babylon, 2023
The relationship between microbiome and metabolomics by studying the microbiota living in the human body and studying their effects on the concentration of metabolites, also to study effects of microbiota colonization on other bacteria or living organism entering the body.
Noor S K Al-Khafaji, Hussein O M Al-Dahmoshi, Zainab Adil Ghani Chabuck, Zena Abdul-Ameer Mahdi, Muhammad Akram, Adrish Sohail, Umme Laila, Rida Zainab, Muhammad Talha Khalil, Momina Iftikhar, Fethi Ahmet Ozdemir   +10 more
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Metabolomic Studies in Drosophila

, 2017
Metabolomic analysis provides a powerful new tool for studies of Drosophila physiology. This approach allows investigators to detect thousands of chemical compounds in a single sample, representing the combined contributions of gene expression, enzyme ...
Carl S Thummel, Cox, J. E., Jason M Tennessen, James E Cox, Thummel, C. S., Tennessen, Jason   +5 more
core   +2 more sources

Bio-Protection as an Alternative to Sulphites: Impact on Chemical and Microbial Characteristics of Red Wines

Frontiers in Microbiology, 2020
In wine, one method of limiting the addition of sulphites, a harmful and allergenic agent, is bio-protection. This practice consists of the early addition of microorganisms on grape must before fermentation. Non-Saccharomyces yeasts have been proposed as
Scott Simonin, Chloé Roullier-Gall, Jordi Ballester, Philippe Schmitt-Kopplin, Philippe Schmitt-Kopplin, Beatriz Quintanilla-Casas, Stefania Vichi, Dominique Peyron, Hervé Alexandre, Raphaëlle Tourdot-Maréchal   +9 more
doaj   +1 more source

Different Wines from Different Yeasts? “Saccharomyces cerevisiae Intraspecies Differentiation by Metabolomic Signature and Sensory Patterns in Wine”

Microorganisms, 2021
Alcoholic fermentation is known to be a key stage in the winemaking process that directly impacts the composition and quality of the final product. Twelve wines were obtained from fermentations of Chardonnay must made with twelve different commercial ...
Fanny Bordet, Chloé Roullier-Gall, Jordi Ballester, Stefania Vichi, Beatriz Quintanilla-Casas, Régis D. Gougeon, Anne Julien-Ortiz, Philippe Schmitt Kopplin, Hervé Alexandre   +8 more
doaj   +1 more source

Metabolomic profile in cycling time trial

, 2022
All metabolite identified for each phase of a 4-km cycling time trial using a non-targeted metabolomic analysis.Also, the metabolomic profile with all metabolite for each phase of the 4-km cycling time trial.
Rafael Azevedo (10263434)
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source