Impact of Metagenomic Next-Generation Sequencing on Antibiotic Management in Pediatric Patients. [PDF]
Medicina (Kaunas)Gonzalez A +3 more
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<i>Tropheryma whipplei</i> as the Dominant Organism in Bronchoalveolar-Lavage Metagenomic Next-Generation Sequencing: A Single-Centre Case Series of 28 Patients. [PDF]
Diagnostics (Basel)Zhang X +6 more
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Identifying viral infections through metagenomic Next Generation Sequencing of undiagnosed respiratory fevers in Madagascar (2014-2019). [PDF]
BMC Infect DisLockwood S +9 more
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The clinical application of metagenomic next-generation sequencing for invasive pulmonary aspergillosis in neutropenic patients: a multicenter retrospective study in the ICU. [PDF]
Front Cell Infect MicrobiolTang J +12 more
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Clinical Metagenomic Next-Generation Sequencing for Pathogen Detection [PDF]
Annual Review of Pathology: Mechanisms of Disease, 2019 Nearly all infectious agents contain DNA or RNA genomes, making sequencing an attractive approach for pathogen detection. The cost of high-throughput or next-generation sequencing has been reduced by several orders of magnitude since its advent in 2004, and it has emerged as an enabling technological platform for the detection and taxonomic ...
Wei Gu, Steve Miller, Charles Y. Chiu
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Neurocysticercosis: diagnosis via metagenomic next-generation sequencing
Practical Neurology, 2023A 68-year-old Brazilian woman had 3 months of progressive fatigue, difficulty walking and 18 kg weight loss. On examination, there was gait apraxia and executive dysfunction. MR scan of brain showed communicating hydrocephalus and a cerebrospinal fluid showed 105 white cells/µL (≤5), predominantly lymphocytes, protein of 1.35 g/L (0.15–0.45) and the ...
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Metagenomics Using Next-Generation Sequencing
2014Traditionally, microbial genome sequencing has been restricted to the small number of species that can be grown in pure culture. The progressive development of culture-independent methods over the last 15 years now allows researchers to sequence microbial communities directly from environmental samples.
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Rapid detection of pulmonary nocardiosis by metagenomic next generation sequencing
Diagnostic Microbiology and Infectious Disease, 2023We retrospectively analyzed 3 cases of pulmonary nocardiosis. Patients were identified by metagenomic next generation sequencing (mNGS) in the First Affiliated Hospital of Soochow University, from January 2019 to April 2022. All patients had underlying diseases, and were in immunocompromised state, with membranous nephropathy, acute lymphoblastic ...
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Adenovirus metagenomic next-generation sequencing
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Metagenomic Next-Generation Sequencing in Clinical Microbiology
Clinical Microbiology Newsletter, 2020Abstract Identification of causative pathogens in infectious disease is a critical component of health care, as infectious diseases continue to be a leading cause of mortality and morbidity worldwide. In addition, the detection of drug resistance by traditional and novel antimicrobial susceptibility testing methods is becoming ever more important as ...
George S. Watts, Bonnie L. Hurwitz
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