Results 231 to 240 of about 4,937,404 (296)

Gut microbiota dysbiosis in the inflammatory pathogenesis of diabetic retinopathy

VIEW, EarlyView.
This graphical abstract illustrates how gut dysbiosis drives diabetic retinopathy through the gut‐retina axis, a process unfolding in three interconnected stages. First, in the gut, a decrease in beneficial bacteria and an increase in pro‐inflammatory taxa compromise the intestinal barrier, causing a “leaky gut” that allows LPS to translocate into the ...
Junyan Hu, Jingxiang Zhong
wiley   +1 more source

Diagnostic Performance of Bronchoalveolar Lavage Fluid Metagenomic Next‑generation Sequencing versus Conventional Microbiological Tests in Immunocompromised and Immunocompetent Patients with Pulmonary Infection. [PDF]

Infect Drug Resist
Song Y, Xu C, Zu F, Dong R, Yang H.
europepmc   +1 more source

Comprehensive evaluation of metagenomic next‐generation sequencing for pathogen identification in patients with suspected infection: Establishment of a standardized validation workflow

VIEW, EarlyView.
Comprehensive evaluation of metagenomic next‐generation sequencing for pathogen identification in patients with suspected infection: Establishment of a standardized validation workflow. Abstract Metagenomic next‐generation sequencing (mNGS) enables unbiased identification of pathogens directly from clinical specimens. Despite its growing application in
Wen Shu, Qiaomei Guo, Han Yang, Huiqin Jiang, Chunyan He, Xueqing Wang, Yuting Fang, Yue Yin, Liwen Zhong, Zhijing Zhao, Jiatao Lou, Lin Wang   +11 more
wiley   +1 more source

Case Report: Pediatric mediastinal actinomycosis mimicking lymphoma diagnosed by tissue metagenomic next-generation sequencing. [PDF]

Front Pediatr
Yi M, Dai Y, Liu C, Lang H, Jiang X, Yuan X.   +5 more
europepmc   +1 more source

Oral microbiome and homeostatic regulation of periodontal health: From dysbiosis to precision intervention

VIEW, EarlyView.
Periodontal homeostasis is maintained by coordinated interactions between the oral microbiome and host. Dysbiosis disrupts this ecological balance and contributes to periodontal disease, whereas multi‐omics, artificial intelligence, and microbiome‐based interventions provide emerging opportunities for precision diagnosis, ecological restoration, and ...
Xu Liu, Lei Meng, Wenzhu Song, Peiyu Wang, Bin Liu, Shihui Liu, Qi He, Bing Sun, Wanheng Li, Zhiwei Guan, Rui Dong, Qiang Feng   +11 more
wiley   +1 more source

<i>Mycobacterium mageritense</i> submandibular lymphadenitis in children: diagnostic challenges and the role of metagenomic next-generation sequencing: two case reports and literature review. [PDF]

Front Med (Lausanne)
Li L, Xing Z, Liu L, Mu X, Zhai Y, Luan S, Li J, Guo Q.   +7 more
europepmc   +1 more source

Single‐target contamination modeling in pathogen metagenomic sequencing via simple linear regression

VIEW, EarlyView.
Abstract A simple linear regression framework was developed to quantify contamination in pathogen metagenomic next‐generation sequencing (mNGS). The model was trained on simulated contamination samples generated by spiking HeLa cell backgrounds (1 × 105 cells/mL) with gradient concentrations of Streptococcus pneumoniae positive standards (5.6 × 106 ...
Xin Liu, Lin Wang, Jiatao Lou, Zhongyu Tan, Sihan Shen, Yanqi Wang, Chenxing Liao, Shengling Chen   +7 more
wiley   +1 more source

Clinical Utility of Metagenomic Next-Generation Sequencing in Adult Patients with Fever of Unknown Origin: A Retrospective Real-World Study. [PDF]

J Clin Med
Guo F, Zhang L, Liu Z, Zhou B, Fan H, Zhang D, Yang Q, Li T, Ge Y.   +8 more
europepmc   +1 more source

Herpesvirus and Adenotonsillar Hypertrophy in Chinese Children: An Epidemiological and Clinical Analysis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective To investigate the possible association between adenotonsillar hypertrophy (ATH) and herpesviral infections in children, and to examine correlations between specific viral detection and clinical characteristics. Methods We enrolled 43 children aged 3–14 years with ATH (mean age 76.56 ± 25.65 months; 31 boys).
Ting‐Ting Ji, Miao Fan, Dan Yu, Xin Ni, Xiao‐Dan Li, Xin‐Yu Wang, Lu Lu, Wen Su, Li‐Xing Tang, Wei Zhang, Xiao Xiao, Yang Han, Lin Mei, Sheng‐Cai Wang   +13 more
wiley   +1 more source

Metagenomic next-generation sequencing in tuberculous periprosthetic joint infection: pathogen-detection yield and clinical characteristics compared with common bacterial PJI. [PDF]

Front Cell Infect Microbiol
Li J, Liao Y, Li X, Lin L, Liu Y, Li W, Huang Z, Wu Z, Fang X, Zhang W.   +9 more
europepmc   +1 more source